Mineral water, therapeutic peloids, favorable landscape and climatic conditions make up the main basis for the creation and development of the health resort business. Mineral water and therapeutic peloids are mineral resources, their prospecting, discovery, exploration and stock assessment of the responsibility of the Geological Survey of the country while the exploration and practical exploitation of the natural medicinal resources is the prerogative of the users of subsurface resources. At present, there are over 1200 deposits of mineral waters as well as more than 260 sources of therapeutic peloids at the territory of the Russian Federation; the include almost all hydrochemical species and types known and exploited in the world’s practice The overall picture of the distribution of the potential and developed deposits of mineral waters and therapeutic peloids of the territory of this country is highly non-uniform and depends on the extent of the economic development of different regions, their geographical and climatic conditions as well as the state and availability of the spa and health resort infrastructure. The natural therapeutic resources, territories suitable for the organization and realization of health promoting activities, setting up new spa and health resort facilities are highly vulnerable to any external impact. We possess the scientifically grounded and practice-proven methods for the search, prospecting, practical development, and medical utilization of various natural therapeutic resources as well as technologies for their conservation, restoration, and protection from damages and overexploitation. The rational use and development of the territories promising for the extension of health resort business imply the necessity of the systemic approach in a consistent stage by stage manner based of the reliable prognoses.