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Gurov A.V.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia;
Sverzhevsky Research Institute of Clinical Otorhinolaryngology

Dubovaya T.K.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Ermolaev A.G.

Pirogov Russian National Research Medical University

Murzakhanova Z.V.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Makhmudova N.R.

Pirogov Russian National Research Medical University

Dombalagyan A.Kh.

Pirogov Russian National Research Medical University

Possibilities of modern forms of antimicrobial peptides in the treatment of inflammatory pathology of the pharynx

Authors:

Gurov A.V., Dubovaya T.K., Ermolaev A.G., Murzakhanova Z.V., Makhmudova N.R., Dombalagyan A.Kh.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2022;87(5): 43‑49

Read: 1613 times


To cite this article:

Gurov AV, Dubovaya TK, Ermolaev AG, Murzakhanova ZV, Makhmudova NR, Dombalagyan AKh. Possibilities of modern forms of antimicrobial peptides in the treatment of inflammatory pathology of the pharynx. Russian Bulletin of Otorhinolaryngology. 2022;87(5):43‑49. (In Russ.)
https://doi.org/10.17116/otorino20228705143

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References:

  1. Kunisawa J, Fukuyama S, Kiyono H. Mucosa-associated lymphoid tissues in the aerodigestive tract: their shared and divergent traits and their importance to the orchestration of the mucosal immune system. Current Molecular Medicine. 2005;5(6):557-572.  https://doi.org/10.2174/1566524054863924
  2. Kiyono H, Fukuyama S. NALT- versus Peyer’s-patch-mediated mucosal immunity. Nature Reviews Immunology. 2004;4(9):699-710.  https://doi.org/10.1038/nri1439
  3. Date Y, Ebisawa M, Fukuda S, Shima H, Obata Y, Takahashi D, Kato T, Hanazato M, Nakato G, Williams IR, Hase K, Ohno H. NALT M cells are important for immune induction for the common mucosal immune system. International Immunology. 2017;29(10):471-478.  https://doi.org/10.1093/intimm/dxx064
  4. Sepahi A, Salinas I. The evolution of nasal immune systems in vertebrates. Molecular Immunology. 2016;69:131-138.  https://doi.org/10.1016/j.molimm.2015.09.008
  5. Pal’chun VT, Krukov AI, Gurov AV, Ermolaev AG. Palatine tonsils: physiology and pathology. Vestnik otorinolaringologii. 2019;84(6):11-16. (In Russ.). https://doi.org/10.17116/otorino20198406111
  6. Lange MJ, Lasiter JC, Misfeldt ML. Toll-like receptors in tonsillar epithelial cells. International Journal of Pediatric Otorhinolaryngology. 2009;73(4):613-621.  https://doi.org/10.1016/j.ijporl.2008.12.013
  7. Pal’chun VT, Gurov AV, Guseva OA. The specific pathogenetic features of the development of chronic tonsillar pathology. Vestnik otorinolaringologii. 2018;83(2):30-33. (In Russ.). https://doi.org/10.17116/otorino201883230-33
  8. Pal’chun VT, Gurov AV, Dubovaya TK, Ermolaev AG. Histological examination of the palatine tonsils in chronic tonsillitis. Meditsinskiy sovet. 2019;(20):68-71. (In Russ.). https://doi.org/10.21518/2079-701X-2019-20-68-71
  9. Gurov AV, Mikhaleva LM, Gordienko MV, Ermolaev AG, Murzakhanova ZV, Muratov DL. Modern methods of assessment of morphofunctional state of various organs and tissues in otolaryngology. Meditsinskiy sovet. 2019;(8):43-47. (In Russ.). https://doi.org/10.21518/2079-701X-2019-8-43-47
  10. Jović M, Avramović V, Vlahović P, Veličkov A, Petrović V. Expression of CD34 and CD146 vascular markers contributes to the immunological function of the human palatine tonsil. Histology and Histopathology. 2018;33(3):261-268.  https://pubmed.ncbi.nlm.nih.gov/28722102/
  11. Avramović V, Petrović V, Jović M, Vlahović P. Quantification of cells expressing markers of proliferation and apoptosis in chronic tonsilitis. Acta Otorhinolaryngologica Italica. 2015;35(4):277-284.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731890/
  12. Ugraş S, Kutluhan A. Chronic tonsillitis can be diagnosed with histopathologic findings. European Journal of General Medicine. 2008;5(2):95-103.  https://www.ejgm.co.uk/article/chronic-tonsillitis-can-be-diagnosed-with-histopathologic-findings-6649
  13. Saito A, Watanabe K, Egawa S, Okubo K. Different Patterns of Acetylation and Dimethylation of Histone H3 between Young and Aged Cases with Chronic Tonsillitis: Influences of Inflammation and Aging. Journal of Nippon Medical School. 2016;83(2):54-61.  https://doi.org/10.1272/jnms.83.54
  14. Svistushkin VM, Mustafaev DM. Acute respiratory viral infections: principles of rational therapy. Rossijskij meditsinskii zhurnal. 2014;26:1897-1902. (In Russ.). https://rusmedreview.com/upload/iblock/1d6/1d6a9a7b1b5030490d109ecd57125858.pdf
  15. Pal’chun VT, Kriukov AI, Gurov AV, Dubovaya TK, Ermolaev AG. Morphofunctional condition of palatine tonsils in various forms of chronic tonsillitis. Meditsinskiy sovet. 2020;(16):150-159. (In Russ.). https://doi.org/10.21518/2079-701X-2020-16-150-159
  16. Skazatova NYu, Piskunov GZ. The prevalence of diseases of the ear, throat and nose in the urban population. Kremlyovskaya medicina. 2016;1:5-10. (In Russ.). https://kremlin-medicine.ru/index.php/km/article/view/934
  17. Khmelnitskaya NM, Vlasova VV, Kosenko VA. Evaluation of the functional state of the palatine tonsils in patients with chronic tonsillitis. Vestnik otorinolaringologii. 2000;4:33-39. (In Russ.). https://www.mediasphera.ru/issues/vestnik-otorinolaringologii/2000/4/
  18. Palchun VT, Gospodar MA, Kolokolchikova EG, Paltsyn AA, Polyakova TS, Chervonskaya NV, Konstantinova NB. Morphological radioautographic study of the palatine tonsils in chronic tonsillitis and in a healthy person. Vestnik otorinolaringologii. 2006;2:4-7. (In Russ.). https://www.mediasphera.ru/issues/vestnik-otorinolaringologii/2006/2/
  19. Alasil SM, Omar R, Ismail S, Yusof MY, Dhabaan GN, Abdulla MA. Evidence of Bacterial Biofilms among Infected and Hypertrophied Tonsils in Correlation with the Microbiology, Histopathology, and Clinical Symptoms of Tonsillar Diseases. International Journal of Otolaryngology. 2013;2013:408238. https://doi.org/10.1155/2013/408238
  20. Burton MJ, Pollard AJ, Ramsden JD, Chong LY, Venekamp RP. Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). The Cochrane Database of Systematic Reviews. 2019;12(12):CD008669. https://doi.org/10.1002/14651858.CD008669.pub3
  21. Nave H, Gebert A, Pabst R. Morphology and immunology of the human palatine tonsil. Anatomy and Embryology. 2001;204(5):367-373.  https://doi.org/10.1007/s004290100210
  22. Dapefrid A, Lundström B, Tano K. Prevalence of Fusobacterium necrophorum in tonsils from patients with chronic tonsillitis. Acta Otolaryngologica. 2017;137(3):297-301.  https://doi.org/10.1080/00016489.2016.1229024
  23. Willis BH, Coomar D, Baragilly M. Comparison of Centor and McIsaac scores in primary care: a meta-analysis over multiple thresholds. British Journal of General Practice. 2020;70(693):245-254.  https://doi.org/10.3399/bjgp20X708833
  24. Pecina JL, Nigon LM, Penza KS, Murray MA, Kronebusch BJ, Miller NE, Jensen TB. Use of the McIsaac Score to Predict Group A Streptococcal Pharyngitis in Outpatient Nurse Phone Triage and Electronic Visits Compared With In-Person Visits: Retrospective Observational Study. Journal of Medical Internet Research. 2021;23(12):e25899. https://doi.org/10.2196/25899
  25. Lang C, Staiger C. Tyrothricin — An underrated agent for the treatment of bacterial skin infections and superficial wounds? Pharmazie. 2016;71(6):299-305.  https://pubmed.ncbi.nlm.nih.gov/27455547/
  26. Korting HC, Schöllmann C, Stauss-Grabo M, Schäfer-Korting M. Antimicrobial peptides and skin: a paradigm of translational medicine. Skin Pharmacology and Physiology. 2012;25(6):323-34.  https://doi.org/10.1159/000341990
  27. Bals R. Antimicrobial peptides and peptide antibiotics. Medizinische Klinik. 2000;95(9):496-502.  https://doi.org/10.1007/pl00002139
  28. Weibel MA, Cortat M, Lebek G, LeCotonnec JY, Kitler ME, Barcherini G. An approach of the in vivo antibacterial activity of benzoxonium chloride and comparison with other buccopharyngeal disinfectants. Arzneimittelforschung. 1987;37(4):467-471.  https://pubmed.ncbi.nlm.nih.gov/3606702/
  29. Iwasawa A, Niwano Y, Kohno M, Ayaki M. Virucidal activity of alcohol-based hand rub disinfectants. Biocontrol Science. 2012;17(1):45-49.  https://doi.org/10.4265/bio.17.45
  30. Wood A, Payne D. The action of three antiseptics/disinfectants against enveloped and non-enveloped viruses. Journal of Hospital Infection. 1998;38(4):283-295.  https://pubmed.ncbi.nlm.nih.gov/9602977/
  31. Kumar M, Chawla R, Goyal M. Topical anesthesia. Journal of Anaesthesiology, Clinical Pharmacology. 2015;31(4):450-456.  https://doi.org/10.4103/0970-9185.169049
  32. Scholten T, Pautler M, Kober G. Duetsche Apotheker Zeitung. 2005;1:93. Accessed September 25, 2022. https://www.deutsche-apotheker-zeitung.de/daz-az/2005/daz-1-2005/uid-13222#:~:text=Schlussfolgerung,Patient%20somit%20schnell%20beschwerdefrei%20ist
  33. Palm J, Fuchs K, Stammer H, Schumacher-Stimpfl A, Milde J; DoriPha investigators. Efficacy and safety of a triple active sore throat lozenge in the treatment of patients with acute pharyngitis: Results of a multi-centre, randomised, placebo-controlled, double-blind, parallel-group trial (DoriPha). International Journal of Clinical Practice. 2018;72(12):e13272. https://doi.org/10.1111/ijcp.13272
  34. Ovchinnikov AYu, Miroshnichenko NA, Nikolaeva YuO. Sore throat. Recent trends in treatment. Vestnik otorinolaringologii. 2020;85(4):35-39. (In Russ.). https://doi.org/10.17116/otorino20208504135
  35. Payganova NE, Yastremsky AP. Prospects of antimicrobial peptides application in otorhinolaryngology in conditions of increasing antibiotic resistance. Vestnik otorinolaringologii. 2021;86(3):104-109. (In Russ.). https://doi.org/10.17116/otorino202186031104

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