The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Ostroumova O.D.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
Russian Medical Academy of Continuing Professional Education

Chikh E.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Svistushkin V.M.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Rebrova E.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Ryazanova A.Y.

Volgograd State Medical University

Rakunova E.B.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of Russia

Drug-induced dysphonia

Authors:

Ostroumova O.D., Chikh E.V., Svistushkin V.M., Rebrova E.V., Ryazanova A.Y., Rakunova E.B.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2020;85(6): 71‑77

DOI: 10.17116/otorino20208506171

Read: 13338 times

Contact the author
Table of contents

DRUG-INDUCED DYSPHONIA
DRUG-INDUCED DYSPHONIA

To cite this article:

Ostroumova OD, Chikh EV, Svistushkin VM, Rebrova EV, Ryazanova AY, Rakunova EB. Drug-induced dysphonia. Russian Bulletin of Otorhinolaryngology. 2020;85(6):71‑77. (In Russ.)
https://doi.org/10.17116/otorino20208506171

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Abstract:

Drug-induced dysphonia is a non-life-threatening adverse drug reaction, however, this complication can significantly worsen the quality of life of patients, especially those in voice-speaking professions. The aim of the work was to search for information about the prevalence, etiology, pathogenesis, and features of treatment and prevention of drug-induced dysphonia. In the case of some drugs, the true prevalence may be higher than described in the literature, due to the fact that dysphonia is in most cases mild, reversible and, in comparison with other undesirable drug reactions, rarely attracts the attention of both the patient and practitioners.

Keywords:

dysphonia
drug-induced dysphonia
adverse drug reaction

Authors:

Ostroumova O.D.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
Russian Medical Academy of Continuing Professional Education

Chikh E.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Svistushkin V.M.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Rebrova E.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Ryazanova A.Y.

Volgograd State Medical University

Rakunova E.B.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of Russia

Received:

17.02.2019

Accepted:

21.05.2020

Close metadata

References:

  1. Cohen SM, Kim J, Roy N, Asche C, Courey M. Prevalence and causes of dysphonia in a large treatment-seeking population. Laryngoscope. 2012;122(2):343-348.  https://doi.org/10.1002/lary.22426
  2. https://www.drugs.com
  3. Drug-induced vocal cord disorders. Prescrire Int. 2018;27(189):13-17. 
  4. Chmielewska M, Akst LM. Dysphonia associated with the use of inhaled corticosteroids. Current Opinion in Otolaryngology & Head and Neck Surgery. 2015;23(3):255-259.  https://doi.org/10.1097/MOO.0000000000000153
  5. Yalcin O, Aslan AA, Sari BA, Turkbay T. Possible Methylphenidate Related Hoarseness and Disturbances of Voice Quality: Two Pediatric Cases. Bulletin of Clinical Psychopharmacology. 2012;22(3):278-282.  https://doi.org/10.5455/bcp.20120731061626
  6. Galván CA, Guarderas JC. Practical Considerations for Dysphonia Caused by Inhaled Corticosteroids. Mayo Clin Proc. 2012;87(9):901-904.  https://doi.org/10.1016/j.mayocp.2012.06.022
  7. Kamba T, Tam BY, Hashizume H, Haskell A, Sennino B, Mancuso MR, et al. VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol. 2006;290:560-576.  https://doi.org/10.1152/ajpheart.00133.2005
  8. Vazquez FJ. Dysphonia Secondary to Perindopril Treatment. AJH. 2003;16:329-330.  https://doi.org/10.1016/S0895-7061(03)00005-0
  9. Schwartz SR, Cohen SM, Dailey SH, Rosenfeld RM, Deutsch ES, Gillespie MB, et al. Clinical practice guideline: hoarseness (dysphonia). Otolaryngol Head Neck Surg. 2009;141(2):1-31.  https://doi.org/10.1016/j.otohns.2009.06.744
  10. Rasimas JJ, Liebelt EL. Adverse Effects and Toxicity of the Atypical Antipsychotics: What is Important for the Pediatric Emergency Medicine Practitioner. Clin Pediatr Emerg Med. 2012;13(4):300-310.  https://doi.org/10.1016/j.cpem.2012.09.005
  11. Tsai CS, Lee Y, Chang YY, Lin PY. Ziprasidone-induced tardive laryngeal dystonia: a case report. Gen Hosp Psychiatry. 2008;30(3):277-279.  https://doi.org/10.1016/j.genhosppsych.2007.08.012.
  12. Collins N, Sager J. Acute laryngeal dystonia: drug-induced respiratory failure related to antipsychotic medications. J Neurol Neuromedicine. 2018;3(1):4-7.  https://doi.org/10.29245/2572.942X/2017/1.1167
  13. Wardle PG, Whitehead MI, Mills RP. Non-reversible and wide ranging voice changes after treatment with danazol. Br Med J (Clin Res Ed). 1983;287(6397):946.  https://doi.org/10.1136/bmj.287.6397.946
  14. Buttram VC, Belue JB, Reiter R. Interim report of a study of danazol for the treatment of endometriosis. Fertil Steril. 1982;37:478-483.  https://doi.org/10.1016/s0015-0282(16)46151-0
  15. Tisdale JE, Miller DA. Drug Induced Diseases: Prevention, Detection, and Management. 3rd Ed. Bethesda, Md.: American Society of Health-System Pharmacists. 2018;1399.
  16. Stachler RJ, Francis DO, Schwartz SR, Damask CC, Digoy GP, Krouse HJ, et al. Clinical Practice Guideline: Hoarseness (Dysphonia) (Update) Executive Summary. Otolaryngol Head Neck Surg. 2018;158(3):409-426.  https://doi.org/10.1177/0194599817751031
  17. Haft S, Farquhar D, Carey R, Mirza N. Anticholinergic use is a major risk factor for dysphonia. Ann Otol Rhinol Laryngol. 2015;124(10):797-802.  https://doi.org/10.1177/0003489415585867
  18. Antón-Aparicio L, Cassinello J, Caneda MCL. Elucidating the biophysic mechanims of axitinib-induced dysphonia. Journal of Clinical Oncology. 2015;33(15):15607-15607. https://doi.org/10.1200/jco.2015.33.15_suppl.e15607
  19. Saavedra E, Hollebecque A, Soria JC, Hartl DM. Dysphonia induced by anti-angiogenic compounds. Invest New Drugs. 2014;32:774-782.  https://doi.org/10.1007/s10637-013-0049-2
  20. Caruso AM, Meyer TK, Allen CT. Hoarseness after metastatic colon cancer treatment. JAMA Otolaryngol Head Neck Surg. 2014;140:881-882.  https://doi.org/10.1001/jamaoto.2014.1766
  21. Reiter R, Hoffmann TK, Pickhard A, Brosch S. Hoarseness — Causes and Treatments. Dtsch Arztebl Int. 2015;112(19):329-237.  https://doi.org/10.3238/arztebl.2015.0329
  22. Otorhinolaryngology. National leadership. Brief Edition. Pod red. V.T. Pal’chuna. M.: GEOTAR-Media; 2014. (In Russ.).
  23. Hakkesteegt MM, Brocaar MP, Wieringa HH. The applicability of the dysphonia severity index and the voice handicap index in evaluating effects of voice therapy and phonosurgery. J Voice. 2010;24(2):199-205.  https://doi.org/10.1016/j.jvoice.2008.06.007.
  24. Nawka T, Verdonck-de Leeuw IM, De Bodt M, Guimaraes I, Holmberg EB, Rosen CA, Schindler A, Woisard V, Whurr R, Konerding U. Item reduction of the voice handicap index based on the original version and on European translations. Folia Phoniatr Logop. 2009;61(1):37-48.  https://doi.org/10.1159/000200767.
  25. Uloza V, Saferis V, Uloziene I. Perceptual and acoustic assessment of voice pathology and the efficiacy of endolaryngeal phonomicrosurgery. J Voice. 2005;19:138-145. 
  26. Shilenkova VV. Acoustic Voice Analysis. Monograph. Yaroslavl: Obverse Plus; 2015. (In Russ.).
  27. Shilenkova VV. Dysphonies and voice. Yaroslavl: Obverse plus; 2018. (In Russ.).
  28. Sizov AG, Meshcheryakov RV, Tiunov SD. Assessment of the voice quality of persons with dysphonia. Trudy SPIIRAN. 2012;1(20):138-152. (In Russ.).
  29. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30(2):239-245.  https://doi.org/10.1038/clpt.1981.154
  30. Williams MLT, Kane C, Shim CS. Treatment of asthma with triamcinolone acetonide delivered by aerosol. Am Rev Respir Dis. 1974;109(5):538-543.  https://doi.org/10.1164/arrd.1974.109.5.538
  31. British Thoracic and Tuberculosis Association. A controlled trial of inhaled corticosteroids in patients receiving Prednisone tablets for asthma. Br J Dis Chest. 1976;70(2):95-103.  https://doi.org/10.1016/0007-0971(76)90013-9
  32. Willey RF, Milne LJR, Crompton GK, Grant IWB. Beclomethasone dipropionate aerosol and oropharyngeal candidiasis. British Journal of Diseases of the Chest. 1976;70:32-38.  https://doi.org/10.1016/0007-0971(76)90004-8
  33. Kass I, Vijayachandra NS, Patil KD. Beclomethasone dipropionate aerosol in the treatment of steroid-dependent asthmatic patients. An assessment of 18 months of therapy. Chest. 1977;71(6):703-707.  https://doi.org/10.1378/chest.71.6.703
  34. Lindgren S, Eriksson NE, Lindholm N. Experience of local inhalation of beclomethasone dipropionate (becotide) in the treatment of adult steroid-dependent asthmatic patients. Stand J Respir Dis. 1977;101:163. 
  35. Toogood JH, Jennings B, Greenway RW, Chuang L Candidiasis and dysphonia complicating beclomethasone treatment of asthma. J Allergy Clin Immunol. 1980;65(2):145-153.  https://doi.org/10.1016/0091-6749(80)90200-6
  36. Williams AJ, Baghat MS, Stableforth DE, Cayton RM, Shenoi PM, Skinner C. Dysphonia caused by inhaled steroids: recognition of a characteristic laryngeal abnormality. Thorax. 1983;38(11):813-821.  https://doi.org/10.1136/thx.38.11.813
  37. Dong JC, Shen ZY, Wang WJ. The investigation on 100 bronchial asthma and asthmatic bronchitis cases treated with high dose beclomethasone dipropionate aerosol [in Chinese]. Zonghua Jie He He Hu Xi Za Zhi. 1993;16(1):33-35. 
  38. Williamson IJ, Matusiewicz SP, Brown PH, Greening AP, Crompton GK. Frequency of voice problems and cough in patients using pressurized aerosol inhaled steroid preparations. Eur Respir J. 1995;8(4):590-592. 
  39. Bhalla RK, Taylor W, Jones AS, Roland NJ. The inflammation produced by corticosteroid inhalers in the pharynx in asthmatics. Clin Otolaryngol. 2008;33(6):581-586.  https://doi.org/10.1111/j.1749-4486.2008.01837.x.
  40. Rachelefsky GS, Liao Y, Faruqi R. Impact of inhaled corticosteroid—induced oropharyngeal adverse events: results from a meta-analysis. Ann Allergy Asthma Immunol. 2007;98(3):225-238.  https://doi.org/10.1016/S1081-1206(10)60711-9
  41. Selroos O, Backman R, Forsén KO, Löfroos AB, Niemistö M, Pietinalho A, et al. Local side-effects during 4-year treatment with inhaled corticosteroids: a comparison between pressurized metered-dose inhalers and Turbuhaler. Allergy. 1994;49(10):888-890.  https://doi.org/10.1111/j.1398-9995.1994.tb00794.x
  42. Andrejak M, Andrejak MT, Osterman G. Enalapril, captopril and cough. Arch Intern Med. 1988;148:249. 
  43. Karpman L. Cough from ACE inhibitors. Am Heart J. 1988;116:1958.
  44. McEwan JR, Choundry N, Street R, Fuller RW. Change in cough reflex after treatment with enalapril and ramipril. Br Med J. 1989;299:13-16.  https://doi.org/10.1136/bmj.299.6690.13
  45. Erdos EG. Some old and new ideas on kinin metabolism. J Cardio-vasc Pharmacol. 1990;15(6):20-24. 
  46. Tenenbaum A, Grossman E, Schemesh J, Fisman E, Nasrati I, Motro M. Intermediate but not low doses of aspirin can suppress angiotensin-converting enzyme inhibitor-induced cough. Am J Hypertens. 2000;13:776-782.  https://doi.org/10.1016/s0895-7061(00)00268-5
  47. Joubert P. Side Effects of Drugs Annual. Side Effects of Drugs Annual. 2005;28:226-232. 
  48. Fuchs M, Bücheler M. Chronic hyperplastic laryngitis following treatment of hypertension with angiotensin converting enzyme-inhibitor. HNO. 2004;52(11):998-1000. https://doi.org/10.1007/s00106-003-1016-6
  49. Carter CA, Caroen SZ, Oronsky AL, Oronsky BT. Dysphonia after Bevacizumab Rechallenge: A Case Report. Case Rep Oncol. 2015;8:423-425.  https://doi.org/10.1159/000441122
  50. Weiser GA, Forouhar FA, White WB, Hydralazine Hoarseness A New Appearance of Drug-Induced Systemic Lupus Erythematosus. Arch Intern Med. 1984;144(11):2271-2272. https://doi.org/10.1001/archinte.1984.04400020199034
  51. Brosch S, Johannsen HS. Medication-induced vocal cord paralysis as an uncommon cause of cord paralysis. HNO. 1999;47(9):825-827.  https://doi.org/10.1007/s001060050467
  52. Bhutta MF, Rance M, Gillett D, Weighill JS. Alendronate-induced chemical laryngitis. The Journal of Laryngology & Otology. 2005;119(1):46-47.  https://doi.org/10.1258/0022215053222969
  53. Singh V, Cohen SM, Rousseau B, Noordzij JP, Garrett CG, Ossoff RH. Acute dysphonia secondary to vocal fold hemorrhage after vardenafil use. Ear Nose Throat J. 2010;89(6):21-22. 
  54. American Academy of Otolaryngology-Head and Neck Surgery. Clinical Practice Guideline: Hoarseness (Dysphonia). https://www.entnet.org/content/clinical-practice-guideline-hoarseness-dysphonia. Published June 24, 2019.
  55. Beglyarov ME. The method of voice restoration in functional dysphonias in persons with voice-speaking professions. Vestnik otorinolaringologii. 2005;5:50-51. (In Russ.).
  56. Stepanova YuYe, Makhotkina NN. Principles of the syndromopathogenetic approach to the appointment of physiotherapy in patients with dysphonia (review). Rossiyskaya otorinolaringologiya. 2013;5(66):126-129. (In Russ.).
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.