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Krukov A.I.

Sverzhevsky Moscow Scientific and Practical Othorhinolaryngology Center, Moscow

Bondareva G.P.

Moskovskiĭ nauchno-prakticheskiĭ Tsentr otorinolaringologii im. L.I. Sverzhevskogo Departamenta zdravookhraneniia Moskvy

Kurbacheva O.M.

Institute of Immunology, Federal Medico-Biological Agency, Moscow, Russia, 115478

Utesheva V.A.

Kafedra otorinolaringologii lechebnogo fakul'teta RNIMU Minzdrava RF, Moskva

Granulomatosis with polyangiitis associated with the cytoplasmic antineutrophil antibodies

Authors:

Krukov A.I., Bondareva G.P., Kurbacheva O.M., Utesheva V.A.

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Journal: Russian Bulletin of Otorhinolaryngology. 2017;82(5): 52‑55

DOI: 10.17116/otorino201782552-55

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To cite this article:

Krukov AI, Bondareva GP, Kurbacheva OM, Utesheva VA. Granulomatosis with polyangiitis associated with the cytoplasmic antineutrophil antibodies. Russian Bulletin of Otorhinolaryngology. 2017;82(5):52‑55. (In Russ.)
https://doi.org/10.17116/otorino201782552-55

Подписка 2025 (Russian Bulletin of Otorhinolaryngology)
 
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The objective of the present work was to analyze the clinical case of granulomatosis with polyangiitis associated with the presence of cytoplasmic antineutrophil antibodies. We considered the medical records of the patient presenting with this condition. It was shown that systemic vasculitis had a polymorphic clinical picture; its diagnostics and treatment encountered serious difficulties. It is concluded that the development of progressive perforation of the nasal septum and destructive changes in the intranasal and adjacent structures after the endonasal surgical intervention implies the necessity of the detailed analysis of the clinical and laboratory observations with the subsequent counselling by a rheumatologist and oncologist for the clarification of the diagnosis and the choice of adequate therapy.

Keywords:

granulomatosis with polyangiitis
cytoplasmic antineutrophil antibodies
nasal obstruction
clinical observation

Authors:

Krukov A.I.

Sverzhevsky Moscow Scientific and Practical Othorhinolaryngology Center, Moscow

Bondareva G.P.

Moskovskiĭ nauchno-prakticheskiĭ Tsentr otorinolaringologii im. L.I. Sverzhevskogo Departamenta zdravookhraneniia Moskvy

Kurbacheva O.M.

Institute of Immunology, Federal Medico-Biological Agency, Moscow, Russia, 115478

Utesheva V.A.

Kafedra otorinolaringologii lechebnogo fakul'teta RNIMU Minzdrava RF, Moskva

List of references:

  1. Shostak NA, Klimenko AA. Systemic vasculitis: novelty in classification, diagnosis and treatment. Klinitsist. 2015;9(2):8-12. (In Russ.)
  2. Blotskiy AA, Karpishchenko SA. Porazheniya LOR-organov pri spetsificheskikh zabolevaniyakh. Metodicheskoye posobiye dlya studentov VUZov, vrachey-internov, klinicheskikh ordinatorov. SPb.: Izdatel’stvo Dialog; 2012. (In Russ.)
  3. Beketova TV. ANTSA-Assotsiirovannyye sistemnyye vaskulity. Uchebno-metodicheskiye materialy. Pod red. Nasonova Ye.L. M.: 2014. (In Russ.)
  4. Watts RA, Lane SE, Bentham G, Scott DGI. Epidemiology of systemic vasculitis — a 10 year study. Arthritis Rheumatology. 2000;43(4):22-427.
  5. Jennette JC, Falk RJ, Bacon PA. Revised international Chapel Hill consensus conference nomenclature of vasculitides. Arthritis Rheumatology. 2013;65:1-11. https://doi.org/10.1002/art.37715
  6. Kallenberg CG. Pathogenesis of ANCA-associated vasculitis, an update. Clinical Reviews in Allergy and Immunology. 2011;41(2):224-231. https://doi.org/10.1007/s12016-011-8258-y
  7. Semenkova YeN. Sistemnyye vaskulity. M.: Izdatel’stvo Meditsina; 1988. (In Russ.)
  8. Klimenko SV, Krivosheev OG. Wegener’s granulomatosis at the present stage: variants of the course, prognosis. Vrach. 2005;12:39-41. (In Russ.)
  9. Yudin AA, Kurbacheva OM, Poletaeva TA, Azerkovich VN Differential diagnosis of bronchial asthma and Chard—Strauss syndrome (analysis of clinical observation). Puĺmonologiya. 2003;1:115-117. (In Russ.)
  10. Levitt RY, Fauci AS, Bloch DA, Michel BA, Hunder GG, Arend WP. The American College of Rheumathology 1990. Criteria for the classification of Wegener’s granulomatosis. Arthritis Rheumatology. 1990;33:1101-1107.
  11. Masi AT, Hunder GG, Lie JT, Michel BA, Bloch DA, Arend WP. The American College of Rheumathology 1990. Criteria for the classification of Churg—Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheumatology. 1990;33:1094-1100.

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