The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kosiakov S.Ia.

Kafedra otorinolaringologii Rossiĭskoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva

Kirdeeva A.I.

Russian Medical Academy for Post-Graduate Education, Moscow, Russia, 125993

The etiopathogenetic aspects of idiopathic sensorineural impairment of hearing

Authors:

Kosiakov S.Ia., Kirdeeva A.I.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2017;82(2): 95‑101

DOI: 10.17116/otorino201681695-101

Read: 2070 times

Download PDF (RU)
Contact the author
Table of contents

THE ETIOPATHOGENETIC ASPECTS OF IDIOPATHIC SENSORINEURAL IMPAIRMENT OF HEARING
THE ETIOPATHOGENETIC ASPECTS OF IDIOPATHIC SENSORINEURAL IMPAIRMENT OF HEARING

To cite this article:

Kosiakov SIa, Kirdeeva AI. The etiopathogenetic aspects of idiopathic sensorineural impairment of hearing. Russian Bulletin of Otorhinolaryngology. 2017;82(2):95‑101. (In Russ.)
https://doi.org/10.17116/otorino201681695-101

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Reha­bilitation of patients with post-COVID syndrome depe­nding on C(159)T poly­morphism of SD-14 gene. Problems of Balneology, Physiotherapy and Exercise Therapy. 2025;(1):42-50
Search for info­rmative predictors of the deve­lopment and progression of multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(9):124-130
Abstract:

The objectives of the present work were the overview of the results of the modern investigations concerning etiology of idiopathic sensorineural impairment of hearing as well as the analysis of the theory of microthrombus formation and its role in pathogenesis of hearing impairment.

Keywords:

idiopathic sensorineural impairment of hearing
genetic polymorphism
formation of microthrombi

Authors:

Kosiakov S.Ia.

Kafedra otorinolaringologii Rossiĭskoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva

Kirdeeva A.I.

Russian Medical Academy for Post-Graduate Education, Moscow, Russia, 125993

Close metadata

References:

  1. Schuknecht HF, Donovan ED. The pathology of idiopathic sudden sensorineural hearing loss. European Archives of Oto-Rhino-Laryngology. 1986;243(1):1-15.
  2. Mattox DE, Simmons FB. Natural history of sudden sensorineural hearing loss. Annals of Otology, Rhinology & Laryngology. 1977;86(4):463-480.
  3. Canis M, Heigl F, Suckfuell M. Fibrinogen/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss. Clinical Research in Cardiology Supplements. 2012;7(1):36-40. doi:10.1007/s11789-012-0044-8
  4. LazariniI PR, Ana Camargo CK. Idiopathic sudden sensorineural hearing loss: etiopathogenic aspects. Brazilian Journal of Otorhinolaryngology.2006;72(4):554-561. doi:10.1590/S0034-72992006000400019
  5. Maggie Kuhn, Selena E. Heman-Ackah, Jamil A. Shaikh, and Pamela C. Roehm. Sudden Sensorineural Hearing Loss. A Review of Diagnosis, Treatment, and Prognosis. Trends in Amplification. 2011;15(3):91-105. doi:10.1177/1084713811408349
  6. Wittig J, Wittekindt C, Kiehntopf M, Guntinas-Lichius O. Prognostic impact of standard laboratory values on outcome in patients with sudden sensorineural hearing loss. BMC Ear, Nose and Throat Disorders. 2014;14(6):1-7. doi:10.1186/1472-6815-14-6
  7. Markus Suckfüll. Perspectives on the Pathophysiology and Treatment of Sudden Idiopathic Sensorineural Hearing Loss. Deutsches Ärzteblatt International . 2009;106(41):669-675. doi:10.3238/arztebl.2009.0669
  8. Shaia FT, Sheehy JL. Sudden sensorineural hearing impairment: a report of 1,220 cases. Laryngoscope. 1976;86(3):389-398. doi:10.1288/00005537-197603000-00008
  9. Sara SA, Teh BM, Friedland P. Bilateral sudden sensorineural hearing loss: review. The Journal of Laryngology & Otology. 2014;128(1):8-15. doi:10.1017/S002221511300306Х
  10. Okamoto M, Shitara T, Nakayama M, Takamiya H, Nishiyama K, Ono Y, Sano H. Sudden deafness accompanied by asymptomatic mumps. Acta otolaryngologica Supplementum. 1994;514:45-48. doi:10.3109/00016489409127557
  11. Takasaki T, Higashikawa M, Motoyama S, Sugita K, Kurane I. Serum antibodies to human herpesvirus 7, human herpesvirus 6 and cytomegalovirus in patients with idiopathic facial nerve palsy or sudden deafness. The Journal of Laryngology & Otology. 1998;112(7):617-621. doi:10.1017/S0022215100141271
  12. Fred H. Linthicum, Jr, Joni Doherty, Karen I. Berliner. Idiopathic Sudden Sensorineural Hearing Loss: Vascular or Viral? Otolaryngology — Head and Neck Surgery. 2013;149(6):914-917. doi:10.1177/0194599813506546
  13. Stokroos RJ, Albers FW, Krikke AP, Casselman JW. Magnetic resonance imaging of the inner ear in patients with idiopathic sudden sensorineural hearing loss. European Archives of Otorhinolaryngology. 1998;255(9):433-436. doi:10.1007/s004050050093
  14. Simmons FB. Theory of membrane breaks in sudden hearing loss. Archives of otolaryngology — head & neck surgery. 1968;88(1):41-48.
  15. Mattox DE, Simmons FB. Natural history of sudden sensorineural hearing loss. Annals of Otology, Rhinology & Laryngology. 1977;86(4Pt 1):463-480.
  16. Merchant SN, Durand ML, Adamsa JC. Sudden Deafness: Is It Viral? ORL; journal for otorhinolaryngology and its related specialties. 2008;70(1):52-62. doi:10.1159/000111048
  17. Merchant SN, Adams JC. Pathology and pathophysiology of idiopathic sudden sensorineural hearing loss. Otology & Neurotology. 2005;26(2):151-160. doi:10.1097/00129492-200503000-00004
  18. Vasama JP, Linthicum FH. Idiopathic sudden sensorineural hearing loss: temporal bone histopathologic study. Annals of Otology, Rhinology & Laryngology. 2000;109(6):527-532. doi:10.1177/000348940010900601
  19. Berrocal JR, Ramírez-Camacho R. Sudden sensorineural hearing loss: supporting the immunologic theory. The Annals of otology, rhinology, and laryngology. 2002;111(11):989-997. doi:10.1177/000348940211101107
  20. Yoo TJ, Tomoda K, Hernandez AD. Type II collagen-induced autoimmune inner ear lesions in guinea pigs. The Annals of otology, rhinology, and laryngology. 1984;113:3-5. doi:10.1126/science.6623056
  21. Boulassel MR, Tomasi JP, Deggouj N, Gersdorff. Identification of beta-actin as a candidate autoantigen in autoimmune inner ear disease. Clinical Otolaryngology and Allied Sciences. 2000;25(6):535-541. doi:10.1046/j.1365-2273.2000.00416.x
  22. Boulassel MR, Deggouj N, Tomasi JP, Gersdorff M. Inner ear autoantibodies and their targets in patients with autoimmune inner ear diseases. Acta otolaryngologica. 2001;121(1):28-34. doi:10.1080/000164801300006236
  23. Solares CA, Edling AE, Johnson JM, Baek MJ, Hirose K, Hughes GB, Tuohy VK. Murine autoimmune hearing loss mediated by CD4+ T cells specific for inner ear peptides. Journal of Clinical Investigation. 2004;113(8):1210-1217. doi:10.1172/JCI200418195
  24. Ural A, Alver A, Işık AU, İmamoğlu M. Serum Leptin Levels in Patients with Idiopathic Sudden Sensorineural Hearing Loss. The Journal of International Advanced Otology. 2014;10(3):201-204. doi:10.5152/iao.2014.321
  25. Yoshida K, Ichimiya I, Suzuki M, Mogi G. Effect of proinflammatory cytokines on cultured spiral ligament fibrocytes. Hearing Research. 1999;137:155-159. doi:10.1016/S0378-5955(99)00134-3
  26. Satoh H, Firestein GS, Billings PB, Harris JP, Keithley EM. Proinflammatory cytokine expression in the endolymphatic sac during inner ear inflam-mation. Journal of the Association for Research in Otolaryngology. 2003;4:139-147. doi:10.1007/s10162-002-3025-7
  27. Maruyoshi H, Toyama K, Kojima S, Kawano H, Ogata N, Miyamoto S, et al. Sensorineural hearing loss combined with Takayasu’s arteritis. Journal of Internal Medicine. 2005;44:124-128. doi:10.2169/internalmedicine.44.124
  28. Gerbig AW, Dahinden CA, Mullis P, Hunziker T. Circadian elevation of IL-6 levels in Muckle-Wells syndrome: a disorder of the neuro-immune axis? An International Journal of Medicine. 1998;91:489-492. doi:10.1093/qjmed/91.7.489
  29. Grondin Y, Bortoni ME, Sepulveda R, Ghelfi E, Bartos A, Cotanche D, Clifford RE, Rogers RA. Genetic Polymorphisms Associated with Hearing Threshold Shift in Subjects during First Encounter with Occupational Impulse Noise. PLoS One. 2015;10(6):0130827. doi:10.1371/journal.pone.0130827
  30. Uchida Y, Sugiura S, Ueda H, Nakashima T, Ando F, Shimokata H. The association between hearing impairment and polymorphisms of genes encoding inflammatory mediators in Japanese aged population. Immunity & Ageing. 2014;11:18. doi:10.1186/s12979-014-0018-4
  31. Moon SK, Park R, Lee HY, Nam GJ, Cha K, Andalibi A, Lim DJ. Spiral ligament fibrocytes release chemokines in response to otitis media pathogens. Acta otolaryngologica. 2006;126:564-569. doi:10.1080/00016480500452525
  32. Adams JC. Clinical implications of inflammatory cytokines in the cochlea: a technical note. Otology & Neurotology. 2002;23:316-322. doi:10.1097/00129492-200205000-00015
  33. Satoh H, Firestein GS, Billings PB, Harris JP, Keithley EM. Tumor necrosis factor-alpha, an initiator, and etanercept, an inhibitor of cochlear inflammation. Laryngoscope. 2002;112:1627-1634. doi:10.1097/00005537-200209000-00019
  34. Aminpour S, Tinling SP, Brodie HA. Role of tumor necrosis factor-alpha in sensorineural hearing loss after bacterial meningitis. Otology & Neurotology. 2005;26:602-609. doi:10.1097/01.mao.0000178121.28365.0d
  35. Krysiak R, Okopien B, Herman Z. Effects of HMG-CoA reductase inhibitors on coagulation and fibrinolysis processes. Drugs. 2003;63:1821-1854. doi:10.2165/00003495-200363170-00005
  36. Green L, Miller EB. Sudden sensorineural hearing loss as a first manifestation of systemic lupus erythematosus: association with anticardiolipin antibodies. Clinical Rheumatology. 2001;20:220-222. doi:10.1007/s100670170069
  37. Marcucci R, Alessandrello LA, Cellai AP, Rogolino A, Berloco P, Leprini E, Pagnini P, Abbate R, Prisco D. Cardiovascular and thrombophilic risk factors for idiopathic sudden sensorineural hearing loss. Journal of Thrombosis and Haemostasis. 3:929-934. doi:10.1111/j.1538-7836.2005.01310.x
  38. Chung SD, Chen PY, Lin HC, Sudden sensorineural hearing loss associated with iron-deficiency anemia: a population-based study. JAMA Otolaryngology — Head & Neck Surgery. 2014;140(5):417-422. doi:10.1001/jamaoto.2014.75
  39. Castiglione A, Ciorba A, Aimoni C, Orioli E, Zeri G, Vigliano M, Gemmati D. Sudden Sensorineural Hearing Loss and Polymorphisms in Iron Homeostasis Genes: New Insights from a Case-Control Study. Bio Med Research International. 2015;01:1-10. doi:10.1155/2015/834736
  40. Gemmati D, Zeri G, Orioli E. Gaetano F, Salvi F, Bartolomei I, D’Alfonso S, Dall’Osso C, Leone AC, Singh AV, Asselta AR, Zamboni P. Polymorphisms in the genes coding for iron binding and transporting proteins are associated with disability, severity, and early progression in multiple sclerosis. BMC Medical Genetics. 2012;13:70. doi:10.1186/1471-2350-13-70
  41. Williams BB, Kwakye GF, Wegrzynowicz M. Altered manganese homeostasis and manganese toxicity in a huntington's disease striatal cell model are not explained by defects in the iron transport system. Toxicological Sciences. 2010;117(1):169-179. doi:10.1093/toxsci/kfq174
  42. Fetoni AR, Bartolo P. Eramo SL, Rolesi R, Paciello F, Bergamini C, Fato R, Paludetti G, Petrosini L, Troiani D. Noise-Induced Hearing Loss (NIHL) as a Target of Oxidative Stress-Mediated Damage: Cochlear and Cortical Responses after an Increase in Antioxidant Defense. The Journal of Neuroscience. 2013;33(9):4011-4023. doi:10.1523/JNEUROSCI.2282-12.2013
  43. Grondin Y, Bortoni EM, Sepulveda R, Ghelfi E, Bartos A, Cotanche D, Clifford RE, Rogers RA. Genetic Polymorphisms Associated with Hearing Threshold Shift in Subjects during First Encounter with Occupational Impulse Noise. PLoS One. 2015;10(6):0130827. doi:10.1371/journal.pone.0130827
  44. Jiang B, Zhang B, Liang P, Song J, Deng H, Tu Z, Deng G, Xiao X. Nucleolin/C23 mediates the antiapoptotic effect of heat shock protein 70 during oxidative stress. FEBS Journal. 2010;277(3):642-652. doi:10.1111/j.17424658.2009.07510.x
  45. Perlman HB, Kimura R, Fernandez C. Experiments on temporary obstruction of the internal auditory artery. Laryngoscope. 1959;69(6):591-613. doi:10.1288/00005537-195906000-00001
  46. Canis M, Heigl F, Suckfuell M. Fibrinogen/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss. BMC Ear, Nose and Throat Disorders. 2012;7(1):36-40. doi:10.1007/s11789-012-0044-8
  47. Passamonti S, Di Berardino F, Bucciarelli P, Berto V, Artoni A, Gianniello F, Ambrosetti U, Cesarani A, Pappalardo E, Martinelli I. Risk factors for idiopathic sudden sensorineural hearing loss and their association with clinical outcome. Thrombosis Research. 2015;135(3):508-512. doi:10.1016/j.thromres.2015.01.001
  48. İkincioğulları A, Köseoğlu S, Kılıç M, Atan D, Özcan KM, Çetin MA, Ensari S, Dere HH. New Inflammation Parameters in Sudden Sensorineural Hearing Loss: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio. The Journal of International Advanced Otology. 2014;10(3):197-200. doi:10.5152/iao.2014.76
  49. Azab B, Shah N, Akerman M, McGinn JT Jr. Value of platelet/lymphocyte ratio as a predictor of all-cause mortality after non-ST-elevation myocardial infarction. Journal of Thrombosis and Thrombolysis. 2012;34:326-334. doi:10.1007/s11239-012-0718-6
  50. Gary T, Pichler M, Belaj K, Hafner F, Gerger A, Froehlich H. Philipp Eller, Rief P, Hackl G, Pilger E, Brodmann M. Platelet-to-lymphocyte ratio: a novel marker for critical limb ischemia in peripheral arterial occlusive disease patients. PLoS One. 2013;8:67688. doi:10.1371/journal.pone.0067688
  51. Tang HY, Fang P, Lin JW, Darilek S, Osborne BT, Haymond JA, Manolidis SB, Roa B, Oghalai JS, Alford RL. DNA sequence analysis and genotype — phenotype assessment in 71 patients with syndromic hearing loss or auditory neuropathy. BMJ Open. 2015;5:007506. doi:10.1136/bmjopen-2014-007506
  52. Keats BJ, Berlin CI. Genomics and hearing impairment. Genome Research. 1999;9(1):7-16. doi:10.1101/gr.9.1.7
  53. Weiss D, Neuner B, Gorzelniak K, Bremer A, Rudack C, Walter M. Platelet Glycoproteins and Fibrinogen in Recovery from Idiopathic Sudden Hearing Loss. PLoS One. 2014;9(1):86898. doi:10.1371/journal.pone.0086898
  54. Cho SH, Chen H, Kim IS, Yokose C, Kang J, Cho D, Cai C, Palma S, Busi M, Martini A, Tae J Yoo. Association of the 4 g/5 g polymorphism of plasminogen activator inhibitor-1 gene with sudden sensorineural hearing loss. A case control study. BMC Ear, Nose and Throat Disorders. 2012;12:5. doi:10.1186/1472-6815-12-5
  55. Suzuki J, Ogawa M, Muto S, Itai A, Hirata Y, Isobe M, Nagai R. Effects of specific chemical suppressors of plasminogen activator inhibitor-1 in cardiovascular diseases. Expert Opinion on Investigational Drugs. 2011;20(2):255-264. doi:10.1517/13543784.2011.546784
  56. Lewis SJ, Ebrahim S, Davey Smith G. Meta-analysis of MTHFR 677C→T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? BMJ. 2005;331(7524):1053. doi:10.1136/bmj.38611.658947.55
  57. Yildiz Z, Ulu A, Incesulu A, Ozkaptan Y, Akar N. The importance of thrombotic risk factors in the development of idiopathic sudden hearing loss. Clinical and Applied Thrombosis/Hemostasis. 2008;14(3):356-359. doi:10.1177/1076029607306399
  58. Pollak A, Mueller-Malesinska M. MTHFR 677T Is a Strong Determinant of the Degree of Hearing Loss Among Polish Males with Postlingual Sensorineural Hearing Impairment. DNA and Cell Biology. 2012;31(7):1267-1273. doi:10.1089/dna.2012.1607
  59. Spiezia L, Vasques F, Bovo R, Martini A, Simioni P. Role of factor V Leiden polymorphism or G20210A prothrombin variant in patients with sudden sensorineural hearing loss: A meta-analysis of the literature. Thrombosis Research. 2015;135(3):423-572. doi:10.1016/j.thromres.2014.12.011
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.