The clinical effectiveness of azithromycin antimicrobial therapy used for the treatment of acute bacterial sinusitis in the patients presenting with concomitant pathology

Kiselev A.B.

Kafedra otorinolaringologii Novosibirskogo gosudarstvennogo meditsinskogo universiteta

Chaukina V.A.

Kafedra otorinolaringologii Novosibirskogo gosudarstvennogo meditsinskogo universiteta

The clinical effectiveness of azithromycin antimicrobial therapy used for the treatment of acute bacterial sinusitis in the patients presenting with concomitant pathology

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Kiselev A.B., Chaukina V.A.

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Journal: Russian Bulletin of Otorhinolaryngology. 2015;80(6): 51‑54

DOI: 10.17116/otorino201580651-54

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To cite this article:

Kiselev AB, Chaukina VA. The clinical effectiveness of azithromycin antimicrobial therapy used for the treatment of acute bacterial sinusitis in the patients presenting with concomitant pathology. Russian Bulletin of Otorhinolaryngology. 2015;80(6):51‑54. (In Russ.)
https://doi.org/10.17116/otorino201580651-54

Подписка 2025-2 (Russian Bulletin of Otorhinolaryngology)

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The objective of the present publication was to report the result of the evaluation of the clinical effectiveness of azithromycin (Sumamed) antimicrobial therapy used for the treatment of bacterial acute rhinsinusitis (ARS) in the patients presenting with concomitant pathology of the respiratory and cardiovascular systems. Dynamics of the reversal of the clinical symptoms of bacterial ARS in the patients of the study group is described. Neither adverse side effects nor complications in response to the treatment were documented. 98.6% of the patients recovered from the disease within 7 days after the onset of the treatment. It is concluded that antimicrobial therapy with the use of azithromycin (Sumamed) based at the outpatient settings provides a highly efficient tool for the treatment of the patients presenting with concomitant pathology of the respiratory and cardiovascular systems

Keywords:

acute sinusitis

antimicrobial therapy

azithromycin

Authors:

Kiselev A.B.

Kafedra otorinolaringologii Novosibirskogo gosudarstvennogo meditsinskogo universiteta

Chaukina V.A.

Kafedra otorinolaringologii Novosibirskogo gosudarstvennogo meditsinskogo universiteta

List of references:

Ovchinnikov A.Yu. O chem sleduet pomnit' prakticheskomu vrachu dlya uspeshnogo lecheniya bakterial'nogo rinosinusita. Dykhanie. 2013;2:11-14.
Rachina S.A., Kozlov R.S., Shal' E.P., Reshet'ko O.V., Palyutin Sh.Kh., Suleimanov S.Sh., Toropova I.A. Analiz praktiki primeneniya antimikrobnykh preparatov u ambulatornykh patsientov s ostrym rinosinusitom v razlichnykh regionakh RF. Rossiiskaya rinologiya. 2012;1:8-12.
Strachunskii L.S., Kozlov S.N. Makrolidy v sovremennoi klinicheskoi praktike. Smolensk: Rusich; 1998.
Ushkalova E.A. Effektivnost' i bezopasnost' azitromitsina pri lechenii vnebol'nichnykh pnevmonii u detei. Farmateka; 2004.
Federal'noe rukovodstvo po ispol'zovaniyu lekarstvennykh sredstv: formulyarnaya sistema. Pod red. Chuchalina A.G., Belousova Yu.B., Yasnetsova V.V. (XII). M.: Ekho; 2011.
Amrol D. Single-dose azithromycin microsphere formulation: a novel delivery system for antibiotics. Int. J Nanomedicine. 2007;2(1):9-12.
Jacobs RF, Maples HD, Aranda JV. Pharmacokinetics of intravenously administered azithromycin in pediatric patients. Pediatr Infect Dis J. 2005;24(21):34-39.
Odenbolt-Tornqvist I, Lowdin E, Cars O. Postantibiotic effects and postantibiotic sub-MIC effects of roxithromycin, clarithromycin and azytromycin on respiratory tract pathogens. Antimicrob Agets Chemother. 1995;39:221-226.
Bergan T. Pharmacokinetics of newer macrolides. In: Neu H.C., Young L.S., Zinner S.H., Acar J.F. New Macrolides, Azalides, and Streptogramins in Clinical Practice. New York; 1995:51-60.
Liu P, Allaudeen H, Chandra R. Comparative pharmacokinetic of azithromycin in serum and white blood cells of healthy subjects receiving a single-dose extended release regimen versus a 3 day Immediate-release regimen. Antimicrob Agents Chemother. 2007;51(1):103-109.
Rubinstein E. Comparative safety of the different macrolides. Int J Antimicrob Agents. 2001;(1):71-76.
Garey KW, Amsden GW. Intravenous azithromycin. Ann. Pharmacother. 1999;33(2):218-228.
Glasbeen JJ, Randolph VF, Prochazka AV. The risk of overanticoagulation with antibiotic use in outpatients on stable warfarin regimens. J Gen Intern Med. 2005;20(7):653-656.
Polaser TM, Miners JO. Quantative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the humane cytochrome P450A substrate. Eur J Clin Pharmacol. 2006;62(3):203-208.
Wright AJ, Gomes T, Mamdani M. The risk of hypotension following co-prescription of macrolide antibiotics and calcium-channel blockers. CMA J. 2011;83(3):303-307.
Lazareva N.V., Luzina E.V. Primenenie generikov v klinicheskoi praktike glazami vrachei terapevticheskogo profilya. VII natsional'nyi kongress terapevtov; noyabr' 7—9, 2012; M.

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