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Orziev S.Kh.

Kafedra otorinolaringologii Andizhanskogo gosudarstvennogo meditsinskogo instituta, Uzbekistan, 170100

Karabaev Kh.

Tashkentskiĭ pediatricheskiĭ meditsinskiĭ institut, Uzbekistan, 700140

Saatov T.S.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

The alteration of the parameters of lipid peroxidation and the antioxidative system in the children presenting with pyo-inflammatory diseases of the middle ear

Authors:

Orziev S.Kh., Karabaev Kh., Saatov T.S.

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Journal: Russian Bulletin of Otorhinolaryngology. 2014;(3): 39‑40

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To cite this article:

Orziev SKh, Karabaev Kh, Saatov TS. The alteration of the parameters of lipid peroxidation and the antioxidative system in the children presenting with pyo-inflammatory diseases of the middle ear. Russian Bulletin of Otorhinolaryngology. 2014;(3):39‑40. (In Russ.)

Подписка 2025 (Russian Bulletin of Otorhinolaryngology)
 
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The objective of the present study was to determine the amount of products of lipid peroxidation (dienic conjugates and malonic dialdehydes) together with antioxidative enzymes (catalase and superoxide dismutase) in 47 children presenting with acute pyo-inflammatory otitis media (APIOM) and 125 patients with chronic suppurative mesotympanitis (CSMT). In addition, 49 children presenting with chronic suppurative epitympanitis (CSET) and chronic suppurative epimesotympanitis (CSEMT) were included in the study. The data obtained were analysed and compared with the similar characteristics of 28 healthy children of the same age comprising the control group. The age of the children in different groups varied between 2 and 14 years. The study revealed the increase in the amount of lipid peroxidation products in all the groups with the simultaneous reduction of the activity of antioxidative enzymes; moreover, these values changed depending on the form and clinical course of the disease.

Keywords:

lipid peroxidation
antioxidant system
acute pyo-inflammatory otitis media
chronic suppurative otitis media

Authors:

Orziev S.Kh.

Kafedra otorinolaringologii Andizhanskogo gosudarstvennogo meditsinskogo instituta, Uzbekistan, 170100

Karabaev Kh.

Tashkentskiĭ pediatricheskiĭ meditsinskiĭ institut, Uzbekistan, 700140

Saatov T.S.

Institut biokhimii Akademii nauk Respubliki Uzbekistan, Tashkent

List of references:

  1. Shilina N.M. Mekhanizmy antioksidantnoy zashchity u detey [The mechanisms of antioxidative protection in the children]. Vopr pitaniya 2011; 6: 20-24.
  2. Gudkovsky V.A. Prirodnye antioksidanty fruktov - nadyozhnaya zashchita cheloveka ot bolezney [The natural antioxidative agents in fruits - the reliable protection of man from diseases]. Vashe pitanie 2001; 1: 22-26.
  3. Sim E.V., Karimov M.Sh. Rol' svobodnoradikal'nogo okisleniya v progressirovanii vospalitel'nogo protsessa pri bolezni Reitera [The role of free radical oxidative stress in the progression of the inflammatory process in the patients presenting with Reiter's disease]. Med zhurn Uzbekistana 2005; 2: 49-51.
  4. Gavrilov V.B., Mishkorudnaya M.I. Spektrofotometricheskoe opredelenie soderzhaniya gidroperekisey lipidov v plazme krovi [The spectrophotometric determination of the lipid hydroperoxide level in blood plasma]. Lab delo 1983; 3: 33-36.
  5. Mkhitaryan V.G., Badalyan G.E. Opredelenie aktivnosti superoksidismutazy [Determination of superoxide dismutase activity]. Zhurn eksper I kiln med 1978; 6: 7-11.
  6. Korolyuk M.A., Ivanova L.I., Maiorova I.G. Opredelenie aktivnosti katalazy [Determination of catalase activity]. Lab delo 1998; 1: 16-19.
  7. Faizulaeva F.N. Obosnovanie primeneniya antioksidantov pri kompleksnom lechenii bol'nykh ostrym I khronicheskim gnoinym srednim otitom s uchyotom pokazateley perekisnogo okisleniya lipidov. Avtoref dis. … kand. med. nauk. Tashkent 1998. [ The rationale for the application of the antioxidative agents for the combined treatment of the patients presenting with acute and chronic suppurative otitis media taking into consideration the parameters of lipid peroxidation. Synopsis of thesis for… the candidate of med. sci. degree]. Tashkent 1998.

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