Wavefront changes after local cross-linking for keratoconus

Anisimov S.I.; Micovic S.M.; Anisimova N.S.; Gavrilova N.A.

doi:https://doi.org/10.17116/oftalma202514105172

Anisimov S.I.

Russian University of Medicine;
OOO Glaznoy centr “Vostok-Prozreniye”

ORCID: 0000-0003-1922-4939

Micovic S.M.

Russian University of Medicine;
OOO Glaznoy Centr “Vostok-Prozrenie”

ORCID: 0009-0002-9396-306X

Anisimova N.S.

Russian University of Medicine;
OOO Glaznoy centr “Vostok-Prozreniye”

ORCID: 0000-0002-6105-1632

Gavrilova N.A.

Russian University of Medicine

ORCID: 0009-0003-2104-7713

Wavefront changes after local cross-linking for keratoconus

Authors:

Anisimov S.I., Micovic S.M., Anisimova N.S., Gavrilova N.A.

More about the authors

Journal: Russian Annals of Ophthalmology. 2025;141(5): 72‑77

DOI: 10.17116/oftalma202514105172

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To cite this article:

Anisimov SI, Micovic SM, Anisimova NS, Gavrilova NA. Wavefront changes after local cross-linking for keratoconus. Russian Annals of Ophthalmology. 2025;141(5):72‑77. (In Russ.)
https://doi.org/10.17116/oftalma202514105172

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)

Использование инфографики авторами научных работ

OBJECTIVE

This study aimed to analyze the dynamics of corneal wavefront aberration changes after local corneal cross-linking and assess their impact on visual acuity in patients with keratoconus.

MATERIAL AND METHODS

The study group included 22 patients (37 eyes) aged 17 to 36 years with stage I—III keratoconus. All patients underwent local corneal cross-linking according to the Dresden protocol. The follow-up period was 12 months. In addition to standard ophthalmological examinations, specialized diagnostics were performed using the topographers-aberrometers Orbscan III, Sirius, and the optical coherence tomograph Revo. Higher-order aberrations were analyzed preoperatively and at 1, 6, and 12 months postoperatively. Corneal morphology parameters were also assessed at the same time points.

RESULTS

At 1 month postoperatively, there was a slight increase in higher-order aberrations compared to baseline. However, by the 6th month, higher-order aberrations began to decrease, reaching their lowest levels by month 12. The improvement in best-corrected visual acuity (BCVA) correlated with the reduction in higher-order aberrations: following a slight decline during the first month, BCVA began to improve by month 6 and peaked by the end of the follow-up period, increasing by 35% (t>2.0; p<0.05) compared with the preoperative level.

CONCLUSION

Local cross-linking has a positive effect on higher-order aberrations. The reduction in higher-order aberrations correlates with improved visual acuity after local crosslinking.

Keywords:

cross-linking

local cross-linking

higher-order aberrations

correlation of visual acuity and higher-order aberrations

Authors:

Anisimov S.I.

Russian University of Medicine;
OOO Glaznoy centr “Vostok-Prozreniye”

ORCID: 0000-0003-1922-4939

Micovic S.M.

Russian University of Medicine;
OOO Glaznoy Centr “Vostok-Prozrenie”

ORCID: 0009-0002-9396-306X

Anisimova N.S.

Russian University of Medicine;
OOO Glaznoy centr “Vostok-Prozreniye”

ORCID: 0000-0002-6105-1632

Gavrilova N.A.

Russian University of Medicine

ORCID: 0009-0003-2104-7713

Received:

06.10.2024

Accepted:

25.11.2024

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References:

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Acceped 25.11.2024