The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Gusev A.A.

Tambov State University named after G.R. Derzhavin;
National University of Science and Technology (MISIS)

Zakharova O.V.

Tambov State University named after G.R. Derzhavin;
National University of Science and Technology (MISIS);
Plekhanov Russian University of Economics

Vasyukova I.A.

Tambov State University named after G.R. Derzhavin

Osmanov R.E.

Tambov branch of S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”

Al-Makhdar Ya.M.

Krasnov Research Institute of Eye Diseases

Nanotechnologies in ophthalmology

Authors:

Gusev A.A., Zakharova O.V., Vasyukova I.A., Osmanov R.E., Al-Makhdar Ya.M.

More about the authors

Journal: Russian Annals of Ophthalmology. 2023;139(4): 107‑114

DOI: 10.17116/oftalma2023139041107

Read: 2968 times

Download PDF (RU)
Contact the author
Table of contents

NANOTECHNOLOGIES IN OPHTHALMOLOGY
NANOTECHNOLOGIES IN OPHTHALMOLOGY

To cite this article:

Gusev AA, Zakharova OV, Vasyukova IA, Osmanov RE, Al-Makhdar YaM. Nanotechnologies in ophthalmology. Russian Annals of Ophthalmology. 2023;139(4):107‑114. (In Russ.)
https://doi.org/10.17116/oftalma2023139041107

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Expe­rimental evaluation of conjunctival reco­nstruction using a collagen membrane. Russian Annals of Ophthalmology. 2026;(2):122-131
3D composite tissue-engineering scaffolds as a donor mate­rial in reco­nstructive surgery of soft tissues: characteristics and current state of the problem. Plastic Surgery and Aesthetic Medi­cine. 2025;(4):97-109
Labo­ratory examination of the dese­nsitizers. Part 1: scanning electron microscope study. Stomatology. 2026;(1):52-57
Abstract:

Application of new materials and methods in the diagnosis and treatment of eye diseases is one of the promising research areas in modern ophthalmology. Significant progress has been made in understanding the pathogenesis, diagnosis and treatment of eye diseases using nanotechnologies and nanomaterials. This paper presents the main achievements and results of original research on this issue. It has been shown that nanoparticles are able to overcome biological barriers, deliver drugs to the target site, and provide the required drug release rate. Modern nanotechnological approaches in tissue engineering are also being actively introduced into ophthalmology, making it possible to create nanoframeworks for growing three-dimensional cellular structures, including arrays of pigment epithelium cells and retinal ganglion cells for the treatment of retinal damage caused by degenerative diseases, injuries and infections.

Keywords:

nanoparticles
nanomedicine
tissue engineering
nanoscaffolds

Authors:

Gusev A.A.

Tambov State University named after G.R. Derzhavin;
National University of Science and Technology (MISIS)

Zakharova O.V.

Tambov State University named after G.R. Derzhavin;
National University of Science and Technology (MISIS);
Plekhanov Russian University of Economics

Vasyukova I.A.

Tambov State University named after G.R. Derzhavin

Osmanov R.E.

Tambov branch of S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”

Al-Makhdar Ya.M.

Krasnov Research Institute of Eye Diseases

Received:

13.10.2022

Accepted:

12.12.2022

Close metadata

References:

  1. Blindness and ocular disorders. World Health Organization 2021. Accessed November 11, 2021. (In Russ.). https://www.who.int/ru/news-room/fact-sheets/detail/blindness-and-visual-impairment
  2. Weng Y, Liu J, Jin S, Guo W, Liang X, Hu, Z. Nanotechnology-based strategies for treatment of ocular disease. Acta Pharm Sin B. 2017;7(3):281-291.  https://doi.org/10.1016/j.apsb.2016.09.001
  3. Fadeel B, Alexiou C. Brave new world revisited: Focus on nanomedicine. Biochem Biophys Res Commun. 2020;533(1):36-49.  https://doi.org/10.1016/j.bbrc.2020.08.046
  4. Jiang S, Franco YL, Zhou Y, Chen J. Nanotechnology in retinal drug delivery. Int J Ophthalmol. 2018;11(6):1038-1044. https://doi.org/10.18240/ijo.2018.06.23
  5. Juliana FR, Kesse S, Boakye-Yiadom KO, Veroniaina H, Wang H, Sun M. Promising Approach in the Treatment of Glaucoma Using Nanotechnology and Nanomedicine-Based Systems. Molecules. 2019;24:3805. https://doi.org/10.3390/molecules24203805
  6. Löscher M, Hurst J, Strudel L, Spitzer MS, Schnichels S. Nanopartikel als Drug-Delivery-Systeme für die Ophthalmologie. Der Ophthalmologe. 2018; 115:184-189.  https://doi.org/10.1007/s00347-017-0596-6
  7. Cho K, Wang X, Nie S, Chen ZG, Shin DM. Therapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res. 2008;14:1310-1316. https://doi.org/10.1158/1078-0432.CCR-07-1441
  8. Zamboulis A, Nanaki S, Michailidou G, Koumentakou I, Lazaridou M, Ainali NM, Xanthopoulou E, Bikiaris DN. Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments. Polymers. 2020;12(7):1519. https://doi.org/10.3390/polym12071519
  9. Suri R, Beg S, Kohli K. Target strategies for drug delivery bypassing ocular barriers. J Drug Deliv Sci Technol. 2019;55:101389. https://doi.org/10.1016/j.jddst.2019.101389
  10. Contreras-Ruiz L, de la Fuente M, García-Vázquez C, Sáez V, Seijo B, Alonso MJ, Calonge M, Diebold Y. Ocular tolerance to a topical formulation of hyaluronic acid and chitosan-based nanoparticles. Cornea. 2010; 29:550-558.  https://doi.org/10.1097/ICO.0b013e3181bd9eee
  11. Silva, M. M., Calado, R., Marto, J., Bettencourt, A., Almeida, A. J., & Gonçalves, L. M. D. Chitosan nanoparticles as a mucoadhesive drug delivery system for ocular administration. Marine drugs. 2017;15(12):370.  https://doi.org/10.3390/md15120370
  12. Costa JR, Silva NC, Sarmento B, Pintado M. Potential chitosan-coated alginate nanoparticles for ocular delivery of daptomycin. Eur J Clin Microbiol Infect Dis. 2015;34:1255-1262. https://doi.org/10.1007/s10096-015-2344-7
  13. ElMeshad AN, Mohsen AM. Enhanced corneal permeation and antimycotic activity of itraconazole against Candida albicans via a novel nanosystem vesicle. Drug Deliv. 2016;23:2115-2123. https://doi.org/10.3109/10717544.2014.942811
  14. Hassan DH, Abdelmonem R, Abdellatif MM. Formulation and Characterization of Carvedilol Leciplex for Glaucoma Treatment: In-Vitro, Ex-Vivo and In-Vivo Study. Pharmaceutics. 2018;10(4):197.  https://doi.org/10.3390/pharmaceutics10040197
  15. Zeng L, Ma W, Shi L, Chen X, Wu R, Zhang Y, Chen, H. Poly(lactic-co-glycolic acid) nanoparticle-mediated interleukin-12 delivery for the treatment of diabetic retinopathy. Int J Nanomed. 2019;14:6357-6369. https://doi.org/10.2147/IJN.S214727
  16. Battaglia L, Serpe L, Foglietta F, Muntoni E, Gallarate M, Del Pozo Rodriguez A, Solinis MA. Application of lipid nanoparticles to ocular drug delivery. Exp Opin Drug Deliv. 2016;13:1743-1757. https://doi.org/10.1080/17425247.2016.1201059
  17. Taha EI, El-Anazi MH, El-Bagory IM, Bayomi MA. Design of liposomal colloidal systems for ocular delivery of ciprofloxacin. Saudi Pharm J. 2014; 22:231-239.  https://doi.org/10.1016/j.jsps.2013.07.003
  18. Zhang R, He R, Qian J, Guo J, Xue K, Yuan YF. Treatment of experimental autoimmune uveoretinitis with intravitreal injection of tacrolimus (FK506) encapsulated in liposomes. Invest Ophthalmol Vis Sci. 2010;51:3575-3582. https://doi.org/10.1167/iovs.09-4373
  19. Salem HF, Ahmed SM, Omar MM. Liposomal flucytosine capped with gold nanoparticle formulations for improved ocular delivery. Drug Design Devel Ther. 2016;10:277-295.  https://doi.org/10.2147/DDDT.S91730
  20. Sahle FF, Kim S, Niloy KK, Tahia F, Fili CV, Cooper E, Hamilton DJ, Lowe TL. Nanotechnology in regenerative ophthalmology. Adv Drug Deliv Rev. 2019;148:290-307.  https://doi.org/10.1016/j.addr.2019.10.006
  21. Yang TC, Chuang JH, Buddhakosai W, Wu WJ, Lee CJ, Chen WS, Yang YP, Li MC, Peng CH, Chen SJ. Elongation of Axon Extension for Human iPSC-Derived Retinal Ganglion Cells by a Nano-Imprinted Scaffold. Int J Mol Sci. 2017;18(9):2013. https://doi.org/10.3390/ijms18092013
  22. Noorani B, Tabandeh F, Yazdian F, Soheili Z-S, Shakibaie M, Rahmani S. Thin natural gelatin/chitosan nanofibrous scaffolds for retinal pigment epithelium cells. Int J Polymer Mater Polymer Biomater. 2018;67:754-763.  https://doi.org/10.1080/00914037.2017.1362639
  23. Hotaling NA, Khristov V, Wan Q, Sharma R, Jha BS, Lotfi M, Maminishkis A, Simon CG Jr, Bharti K. Nanofiber Scaffold-Based Tissue-Engineered Retinal Pigment Epithelium to Treat Degenerative Eye Diseases. J Ocul Pharmacol Ther. 2016;32:272-285.  https://doi.org/10.1089/jop.2015.0157
  24. Gonçalves S, Padrão J, Rodrigues IP, Silva JP, Sencadas V, Lanceros-Mendez S, Girão H, Dourado F, Rodrigues LR. Bacterial cellulose as a support for the growth of retinal pigment epithelium. Biomacromolecules. 2015;16(4): 1341-1351. https://doi.org/10.1021/acs.biomac.5b00129
  25. Jha BS, Bharti K. Regenerating Retinal Pigment Epithelial Cells to Cure Blindness: A Road Towards Personalized Artificial Tissue. Curr Stem Cell Rep. 2015;1(2):79-91.  https://doi.org/10.1007/s40778-015-0014-4
  26. Da Silva GR, Lima TH, Oréfice RL, Fernandes-Cunha GM, Silva-Cunha A, Zhao M, Behar-Cohen F. In vitro and in vivo ocular biocompatibility of electrospun poly(ɛ-caprolactone) nanofibers. Eur J Pharm Sci. 2015;73:9-19.  https://doi.org/10.1016/j.ejps.2015.03.003
  27. McHugh KJ, Tao SL, Saint-Geniez M. Porous poly(ε-caprolactone) scaffolds for retinal pigment epithelium transplantation. Invest Ophthalmol Vis Sci. 2014;55(3):1754-1762. https://doi.org/10.1167/iovs.13-12833
  28. Ilmarinen T, Hiidenmaa H, Kööbi P, Nymark S, Sorkio A, Wang JH, Stanzel BV, Thieltges F, Alajuuma P, Oksala O, Kataja M, Uusitalo H, Skottman H. Ultrathin Polyimide Membrane as Cell Carrier for Subretinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigment Epithelium. PLoS One. 2015;10(11):e0143669. https://doi.org/10.1371/journal.pone.0143669
  29. Xiang P, Wu KC, Zhu Y, Xiang L, Li C, Chen DL, Chen F, Xu G, Wang A, Li M, Jin ZB. A novel Bruch’s membrane-mimetic electrospun substrate scaffold for human retinal pigment epithelium cells. Biomaterials. 2014; 35(37):9777-9788. https://doi.org/10.1016/j.biomaterials.2014.08.040
  30. Kador KE, Grogan SP, Dorthé EW, Venugopalan P, Malek MF, Goldberg JL, D’lima DD. Control of Retinal Ganglion Cell Positioning and Neurite Growth: Combining 3D Printing with Radial Electrospun Scaffolds. Tissue Eng Part A. 2016;22(3-4):286-294.  https://doi.org/10.1089/ten.TEA.2015.0373
  31. White CE, Olabisi RM. Scaffolds for retinal pigment epithelial cell transplantation in age-related macular degeneration. J Tissue Eng. 2017;8.  https://doi.org/10.1177/2041731417720841
  32. Warnke PH, Alamein M, Skabo S, Stephens S, Bourke R, Heiner P, Liu Q. Primordium of an artificial Bruch’s membrane made of nanofibers for engineering of retinal pigment epithelium cell monolayers. Acta Biomater. 2013;9(12):9414-9422. https://doi.org/10.1016/j.actbio.2013.07.029
  33. Lu JT, Lee CJ, Bent SF, Fishman HA, Sabelman EE. Thin collagen film scaffolds for retinal epithelial cell culture. Biomaterials. 2007;28(8):1486-1494. https://doi.org/10.1016/j.biomaterials.2006.11.023
  34. Sorkio AE, Vuorimaa-Laukkanen EP, Hakola HM, Liang H, Ujula TA, Valle-Delgado JJ, Österberg M, Yliperttula ML, Skottman H. Biomimetic collagen I and IV double layer Langmuir—Schaefer films as microenvironment for human pluripotent stem cell derived retinal pigment epithelial cells. Biomaterials. 2015;51:257-269.  https://doi.org/10.1016/j.biomaterials.2015.02.005
  35. Rose JB, Pacelli S, Haj AJE, Dua HS, Hopkinson A, White LJ, Rose, F. Gelatin-Based Materials in Ocular Tissue Engineering. Materials (Basel, Switzerland). 2014;7(4):3106-3135. https://doi.org/10.3390/ma7043106
  36. Malafaya PB, Silva GA, Reis RL. Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. Adv Drug Deliv Rev. 2007;59(4-5):207-233.  https://doi.org/10.1016/j.addr.2007.03.012
  37. Harkin DG, George KA, Madden PW, Schwab IR, Hutmacher DW, Chirila TV. Silk fibroin in ocular tissue reconstruction. Biomaterials. 2011;32(10): 2445-2458. https://doi.org/10.1016/j.biomaterials.2010.12.041
  38. Karamichos D. Ocular tissue engineering: current and future directions. J Funct Biomater. 2015;6(1):77-80.  https://doi.org/10.3390/jfb6010077
  39. Calejo MT, Ilmarinen T, Vuorimaa-Laukkanen E, Talvitie E, Hakola HM, Skottman H, Kellomäki M. Langmuir-Schaefer film deposition onto honeycomb porous films for retinal tissue engineering. Acta Biomater. 2017;54: 138-149.  https://doi.org/10.1016/j.actbio.2017.02.035
  40. Nadri S, Kazemi B, Eeslaminejad MB, Yazdani S, Soleimani M. s. Mol Biol Rep. 2013;40(6):3883-3890. https://doi.org/10.1007/s11033-012-2360-y
  41. Chen F, Si P, de la Zerda A, Jokerst JV, Myung D. Gold nanoparticles to enhance ophthalmic imaging. Biomater Sci. 2021;9:367-390.  https://doi.org/10.1039/d0bm01063d
  42. Nguyen VP, Li Y, Qian W, Liu B, Tian C, Zhang W, et al. Contrast agent enhanced multimodal photoacoustic microscopy and optical coherence tomography for imaging of rabbit choroidal and retinal vessels in vivo. Sci Rep. 2019;9(1):1-17. 
  43. Nguyen VP, Qian W, Li Y, et al. Chain-like gold nanoparticle clusters for multimodal photoacoustic microscopy and optical coherence tomography enhanced molecular imaging. Nat Commun. 2021;12:34.  https://doi.org/10.1038/s41467-020-20276-z
  44. Chemla Y, Betzer O, Markus A, Farah N, Motiei M, Popovtzer R, Mandel Y. Gold nanoparticles for multimodal high-resolution imaging of transplanted cells for retinal replacement therapy. Nanomedicine. 2018;14:1857-1871. https://doi.org/10.2217/nnm-2018-0299
  45. Kubelick KP, Snider EJ, Ethier CR, Emelianov S. Development of a stem cell tracking platform for ophthalmic applications using ultrasound and photoacoustic imaging. Theranostics. 2019;9(13):3812-3824. https://doi.org/10.7150/thno.32546
  46. Jo DH, Lee TG, Kim JH. Nanotechnology and Nanotoxicology in Retinopathy. Int J Mol Sciences. 2011;12:8288-8301. https://doi.org/10.3390/ijms12118288
  47. Söderstjerna E, Patrik Bauer P, Cedervall T, Abdshill H, Johansson F, Johansson UE. Silver and Gold Nanoparticles Exposure to In Vitro Cultured Retina — Studies on Nanoparticle Internalization, Apoptosis, Oxidative Stress, Glial- and Microglial Activity. PLoS One. 2014;9(8):e105359.
  48. Pershina AG, Sazonov AE, Milto IV. Application of magnetic nanoparticles in biomedicine. Bulletin of Siberian Medicine. 2008;7(2):70-78. (In Russ.). https://doi.org/10.20538/1682-0363-2008-2-70-78
  49. Robinson DB, Persson HHJ, Zeng H. et al. DNA-Functionalized MFe2O4 (M=Fe, Co, or Mn) Nanoparticles and Their Hybridization to DNA-Functionalized Surfaces. Langmuir. 2005;21:3096-3103.
  50. Fortin-Ripoche J-P, Martina M-S, Gazeau F, et al. Magnetic targeting of magnetolipoaomes to solid tumors with MR imaging monitoring in mice: feasibility. Radiology. 2006;239(2):415-424. 
  51. Vasyukov GYu, Mitrofanova IV, Ivanova VV, Prokopiyeva VD. Surface modifited magnetic nanoparticles for biomedical application. Bulletin of Siberian Medicine. 2014;13(6):33-40 (In Russ.). https://doi.org/10.20538/1682-0363-2014-6-33-40
  52. Malhotra N, Lee JS, Liman RAD, Ruallo JMS, Villaflores OB, Ger TR, Hsiao CD. Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review. Molecules. 2020;25(14):3159. https://doi.org/10.3390/molecules25143159
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.