The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Oganesyan O.G.

Helmholtz National Medical Research Center of Eye Diseases

Ashikova P.M.

Helmholtz National Medical Research Center of Eye Diseases

Ivanova A.V.

Helmholtz National Medical Research Center of Eye Diseases

Letnikova K.B.

Helmholtz National Medical Research Center of Eye Diseases

Transplantation of the Bowman’s layer in combined treatment of recurrent pterygium

Authors:

Oganesyan O.G., Ashikova P.M., Ivanova A.V., Letnikova K.B.

More about the authors

Journal: Russian Annals of Ophthalmology. 2023;139(3): 90‑97

DOI: 10.17116/oftalma202313903190

Read: 1501 times

Download PDF (RU)
Contact the author
Table of contents

TRANSPLANTATION OF THE BOWMAN’S LAYER IN COMBINED TREATMENT OF RECURRENT PTERYGIUM
TRANSPLANTATION OF THE BOWMAN’S LAYER IN COMBINED TREATMENT OF RECURRENT PTERYGIUM

To cite this article:

Oganesyan OG, Ashikova PM, Ivanova AV, Letnikova KB. Transplantation of the Bowman’s layer in combined treatment of recurrent pterygium. Russian Annals of Ophthalmology. 2023;139(3):90‑97. (In Russ.)
https://doi.org/10.17116/oftalma202313903190

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Method for obtaining a pre-Descemet’s stro­mal layer graft. Russian Annals of Ophthalmology. 2025;(5):82-86
Abstract:

Pterygium is among the most frequent indications for extraocular ophthalmic surgery. The main method of pterygium treatment — its excision — is often combined with transplantation, non-transplantation, medication and other methods. However, the frequency of pterygium recurrence can exceed 35%, and the cosmetic and refraction outcomes satisfy neither the patient, nor the surgeon.

PURPOSE

The study analyses the technical capability and feasibility for transplantation of the Bowman’s layer in the treatment of recurrent pterygium.

MATERIAL AND METHODS

The transplantation of the Bowmen’s layer was performed according to the developed technique on 7 eyes with recurrent pterygium (7 patients aged 34 to 63 years). The combined surgery technique consisted of pterygium resection, laser ablation, autoconjunctival plasty, exposure to a cytostatic drug, non-suture transplantation of the Bowman’s layer. Maximum length of the follow-up was 36 months. Analysis involved data from refractometry, visometry (without correction and with spectacle correction), and optical coherence tomography of the retina.

RESULTS

There were no complications in any of the studied cases. The cornea and the transplant retained transparency throughout the entire follow-up duration. 36 months after surgery mean spectacle-corrected visual acuity amounted to 0.86±0.2, topographic astigmatism — 1.48±1.4 diopters. Recurrence of pterygium was not observed. All patients were satisfied with the cosmetic outcomes of the treatment.

CONCLUSION

Non-suture transplantation of the Bowmen’s layer recovers normal anatomy, physiology and transparency of the cornea after repeat surgical intervention for pterygium. No pterygium recurrences were observed throughout the entire follow-up after treatment with the proposed combined technique.

Keywords:

transplantation of Bowman’s layer
pterygium
corneal transplantation
excimer laser ablation
lamellar keratoplasty

Authors:

Oganesyan O.G.

Helmholtz National Medical Research Center of Eye Diseases

Ashikova P.M.

Helmholtz National Medical Research Center of Eye Diseases

Ivanova A.V.

Helmholtz National Medical Research Center of Eye Diseases

Letnikova K.B.

Helmholtz National Medical Research Center of Eye Diseases

Received:

14.05.2022

Accepted:

12.12.2022

Close metadata

References:

  1. Gutierrez AM, Mejia LF. Pterygium Surgical Management. In: Boyd S., Boyd B.F., eds. New Trends in Ophthalmology-Medical and Surgical Management. Panama: Jaypee-Highlights Medical Publishers; 2013.
  2. Malozhen SA, Trufanov SV, Krakhmaleva DA. Pterygium: etiology, pathogenesis, treatment. Russian Annals of Ophthalmology = Vestnik Oftalmologii. 2017;133(5):76-83. (In Russ.). https://doi.org/10.17116/oftalma2017133576-83
  3. Spencer WH, Zimmerman LE. Conjunctiva. In: Spencer WH, ed. Ophthalmic pathology: an atlas and textbook. Vol 1. Philadelphia: WB Saunders; 1985.
  4. Coroneo M, Di Girolamo N, Wakefield D. The pathogenesis of pterygia. Curr Opin Opthalmol. 1999;10(4):282-288.  https://doi.org/10.1097/00055735-199908000-00011
  5. Biender B, Biger Y, Rothkoff L, Sachs U. Pterygium and basic tear secretion. Ann Ophthalmol. 1979;11(8):1235-1236.
  6. Petrayevsky AV, Trishkin KS. Pathogenetic relationship between pterygium and dry eye syndrome (clinical and cytological study). Russian Annals of Ophthalmology = Vestnik Oftalmologii. 2014;130(1):52-56. (In Russ.).
  7. Hilgers J. Pterygium: its incidence, heredity and etiology. Am J Ophthalmol. 1960;50:635-644.  https://doi.org/10.1016/0002-9394(60)90245-2
  8. Gris O, Güell JL, del Campo Z. Limbal-conjunctival autograft transplantation for the treatment of recurrent pterygium. Ophthalmology. 2000;107(2): 270-273.  https://doi.org/10.1016/s0161-6420(99)00041-x
  9. Barbosa J, De Farias C, Hirai F, Pereira Gomes J. Amniotic membrane transplantation with narrow-strip conjunctival autograft vs conjunctival autograft for recurrent pterygia. Eur J Ophthalmol. 2017;27(2):135-140.  https://doi.org/10.5301/ejo.5000773
  10. Assaad N, Chong R, Tat L, Bennett M, Coroneo M. Use of adjuvant hyperbaric oxygen therapy to support limbal conjunctival graft in the management of recurrent pterygium. Cornea. 2011;30(1):7-10.  https://doi.org/10.1097/ICO.0b013e3181da58a4
  11. Besharati M, Manaviat M, Souzani A. Subconjunctival bevacizumab injection in treatment of pterygium. Acta Med Iran. 2011;49(3):179-183. 
  12. Kaufman S, Jacobs D, Lee W, Deng S, Rosenblatt M, Shtein R. Options and adjuvants in surgery for pterygium: a report by the American Academy of Ophthalmology. Ophthalmology. 2013;120(1):201-208.  https://doi.org/10.1016/j.ophtha.2012.06.066
  13. Simşek T, Günalp I, Atilla H. Comparative efficacy of beta-irradiation and mitomycin-C in primary and recurrent pterygium. Eur J Ophthalmol. 2001; 11(2):126-132.  https://doi.org/10.1177/112067210101100204
  14. Chui J, Coroneo M, Tat L, Crouch R, Wakefield D, Di Girolamo N. Ophthalmic pterygium: a stem cell disorder with premalignant features. Am J Pathology. 2011;178(2):817-827.  https://doi.org/10.1016/j.ajpath.2010.10.037
  15. Reid T, Dushku N. What a study of pterygia teaches us about the cornea? Molecular mechanisms of formation. Eye Contact Lens. 2010;36(5):290-295.  https://doi.org/10.1097/ICL.0b013e3181eea8fe
  16. Zeng W, Liu Z, Dai H, Yan M, Luo H, Ke M, Cai X. Anti-fibrotic, anti-VEGF or radiotherapy treatments as adjuvants for pterygium excision: a systematic review and network meta-analysis. BMC Ophthalmol. 2017;17(1):211.  https://doi.org/10.1186/s12886-017-0601-5
  17. Walland M, Stevens J, Steele A. The effect of recurrent pterygium on corneal topography. Cornea. 1994;13(5):463-464.  https://doi.org/10.1097/00003226-199409000-00016
  18. Tan D, Chee S, Dear K, Lim A. Effect of pterygium morphology on pterygium recurrence in a controlled trial comparing conjunctival autografting with bare sclera excision. Arch Ophthalmol. 1997;115(10):1235-1240. https://doi.org/10.1001/archopht.1997.01100160405001
  19. Oganesyan OG, Getadaryan VR, Makarov PV, Grdikanyan AA. Bowman layer transplantation in eyes with progressive advanced keratoconus. Russian Ophthalmological Journal = Rossiyskiy oftal’mologicheskiy zhurnal. 2019;12(4): 43-50. (In Russ.). https://doi.org/10.21516/2072-0076-2019-12-4-43-50
  20. Mayer D, Casey T. Reducing the risk of corneal graft rejection. A comparison of different methods. Cornea. 1987;6(4):261-268.  https://doi.org/10.1097/00003226-198706040-00006
  21. Krag S, Ehlers N. Excimer laser treatment of pterygium. Acta Ophthalmol (Copenh). 1992;70(4):530-533.  https://doi.org/10.1111/j.1755-3768.1992.tb02127.x
  22. Promesberger J, Kohli S, Busse H, Uhlig C. Pterygium recurrence, astigmatism and visual acuity following bare-sclera excision and conjunctival autograft with or without additional phototherapeutic keratectomy. Ophthalmic Res. 2014;51(1):52-58.  https://doi.org/10.1159/000355075
  23. Chen D, Liu X, Long Q, Wang Z, Li Y. Effects of excimer laser phototherapeutic keratectomy in limbal-conjunctival autograft transplantation for recurrent pterygium: a retrospective case control study. BMC Ophthalmol. 2019;19(1):238.  https://doi.org/10.1186/s12886-019-1248-1
  24. Gierek-Kalicka S, Mrukwa E, Wygledowska D. Use of excimer laser in pterygium surgery. Klin Oczna. 1992;94(11-12):371-372. 
  25. Walkow T, Daniel J, Meyer C, Rodrigues E, Mennel S. Long-term results after bare sclera pterygium resection with excimer smoothing and local application of mitomycin C. Cornea. 2005;24(4):378-381.  https://doi.org/10.1097/01.ico.0000151540.69994.ef
  26. Hirst L. The treatment of pterygium. Surv Ophthalmol. 2003;48(2):145-180.  https://doi.org/10.1016/s0039-6257(02)00463-0
  27. Hirst L. Prospective study of primary pterygium surgery using pterygium extended removal followed by extended conjunctival transplantation. Ophthalmology. 2008;115(10):1663-1672. https://doi.org/10.1016/j.ophtha.2008.03.012
  28. Lie J, Droutsas K, Ham L, Dapena I, Ververs B, Otten H, van der Wees J, Melles G. Isolated Bowman layer transplantation to manage persistent subepithelial haze after excimer laser surface ablation. J Cataract Refract Surg. 2010;36(6):1036-1041. https://doi.org/10.1016/j.jcrs.2010.03.032
  29. Di Girolamo N, Coroneo M, Wakefield D. Epidermal growth factor receptor signaling is partially responsible for the increased matrix metalloproteinase-1 expression in ocular epithelial cells after UVB radiation. Am J Pathol. 2005;167(2):489-503.  https://doi.org/10.1016/S0002-9440(10)62992-6
  30. Di Girolamo N, Wakefield D, Coroneo M. UVB-mediated induction of cytokines and growth factors in pterygium epithelial cells involves cell surface receptors and intracellular signaling. Invest Ophthalmol Vis Sci. 2006;47(6): 2430-2437. https://doi.org/10.1167/iovs.05-1130
  31. Melles G, Binder P, Anderson J. Variation in healing throughout the depth of long-term, unsutured, corneal wounds in human autopsy specimens and monkeys. Arch Ophthalmol. 1994;112(1):100-109.  https://doi.org/10.1001/archopht.1994.01090130110027
  32. Lagali N, Germundsson J, Fagerholm P. The role of Bowman’s layer in corneal regeneration after phototherapeutic keratectomy: a prospective study using in vivo confocal microscopy. Invest Ophthalmol Vis Sci. 2009;50(9):4192-4198. https://doi.org/10.1167/iovs.09-3781
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.