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Ronzina I.A.

Research Institute of Eye Diseases

Sheremet N.L.

Krasnov Research Institute of Eye Diseases

Zhorzholadze N.V.

Research Institute of Eye Diseases

Multifocal electroretinography in assessment of the functional state of the central retina in patients with retinitis pigmentosa

Authors:

Ronzina I.A., Sheremet N.L., Zhorzholadze N.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2022;138(6): 44‑54

DOI: 10.17116/oftalma202213806144

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MULTIFOCAL ELECTRORETINOGRAPHY IN ASSESSMENT OF THE FUNCTIONAL STATE OF THE CENTRAL RETINA IN PATIENTS WITH RETINITIS PIGMENTOSA
MULTIFOCAL ELECTRORETINOGRAPHY IN ASSESSMENT OF THE FUNCTIONAL STATE OF THE CENTRAL RETINA IN PATIENTS WITH RETINITIS PIGMENTOSA

To cite this article:

Ronzina IA, Sheremet NL, Zhorzholadze NV. Multifocal electroretinography in assessment of the functional state of the central retina in patients with retinitis pigmentosa. Russian Annals of Ophthalmology. 2022;138(6):44‑54. (In Russ., In Engl.)
https://doi.org/10.17116/oftalma202213806144

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Retinitis pigmentosa (RP) is an inherited disease associated with various genetic mutations. Developments in the field of genetic engineering give relevance to the search for methods of studying retinal function, which can prove informative in the selection of patients for treatment.

PURPOSE

To evaluate the information content of multifocal electroretinography (mfERG) in the diagnostics of the functional state of the central retina in retinitis pigmentosa (RP).

MATERIAL AND METHODS

The study included 115 patients (228 eyes) with PR and 15 people (30 eyes) who comprised the control group. All subjects underwent standard ophthalmological examination, computer perimetry, color vision study, retinal spectral optical coherence tomography, ganzfeld electroretinography (gERG) and mfERG. The relationship between mfERG parameters and the degree of gERG changes, as well as various functional and morphological parameters of the retina was assessed.

RESULTS

Visual acuity and perimetry indices varied over a wide range. GERG was unrecordable in 50.4% of cases. MfERG was registered in 214 (98.3%) eyes with varying degrees of change in visual acuity, visual field and gERG parameters. A medium degree positive relationship was revealed between the biopotential density of the retina in the foveal and parafoveal zones and visual acuity (rs=0.68; 0.63), a high degree — between the density of ttotal biopotential of the central retina (DValue) and the average light sensitivity (rs=0.9), a weak degree — between DValue and the thickness and volume of the peripheral retina (rs=0.37; 0.42), a medium negative correlation was found between the average defect in light sensitivity and the biopotential density in the periphery (Rings 4—5) on mfERG, DValue (rs= –0.67; –0.65; –0.69).

CONCLUSION

MfERG detects retinal dysfunctions at an early stage of RP, in eyes with high visual acuity, normal parameters of the central visual field and gERG, as well as in low visual acuity, a pronounced decrease in light sensitivity, unrecordable gERG. MfERG can be informative in the selection of patients with RP for gene therapy.

Keywords:

retinitis pigmentosa
ganzfeld electroretinography
multifocal electroretinography

Authors:

Ronzina I.A.

Research Institute of Eye Diseases

Sheremet N.L.

Krasnov Research Institute of Eye Diseases

Zhorzholadze N.V.

Research Institute of Eye Diseases

Received:

27.12.2021

Accepted:

13.04.2022

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