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Yusef Yu.N.

Krasnov Research Institute of Eye Diseases;
I.M. Sechenov First Moscow State Medical University (Sechenov University)

Gamidov A.A.

Krasnov Research Institute of Eye Diseases

Baum O.I.

Institute of Photonic Technologies of the Crystallography and Photonics Research Center

Yuzhakov A.V.

Institute of Photonic Technologies of the Crystallography and Photonics Research Center

Medvedeva E.P.

Krasnov Research Institute of Eye Diseases

Kasianenko E.M.

Institute of Photonic Technologies of the Crystallography and Photonics Research Center

On studying the mechanisms and assessing the safety of Nd:YAG laser irradiation of the posterior lens capsule (experimental and clinical study)

Authors:

Yusef Yu.N., Gamidov A.A., Baum O.I., Yuzhakov A.V., Medvedeva E.P., Kasianenko E.M.

More about the authors

Journal: Russian Annals of Ophthalmology. 2022;138(5): 47‑56

DOI: 10.17116/oftalma202213805147

Read: 1546 times

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ON STUDYING THE MECHANISMS AND ASSESSING THE SAFETY OF ND:YAG LASER IRRADIATION OF THE POSTERIOR LENS CAPSULE (EXPERIMENTAL AND CLINICAL STUDY)
ON STUDYING THE MECHANISMS AND ASSESSING THE SAFETY OF ND:YAG LASER IRRADIATION OF THE POSTERIOR LENS CAPSULE (EXPERIMENTAL AND CLINICAL STUDY)

To cite this article:

Yusef YuN, Gamidov AA, Baum OI, Yuzhakov AV, Medvedeva EP, Kasianenko EM. On studying the mechanisms and assessing the safety of Nd:YAG laser irradiation of the posterior lens capsule (experimental and clinical study). Russian Annals of Ophthalmology. 2022;138(5):47‑56. (In Russ.)
https://doi.org/10.17116/oftalma202213805147

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

YAG laser interventions are associated with the risk of complications, including corneal.

PURPOSE

To study the mechanisms of laser destruction in exposing the posterior lens capsule (PLC) tissue to Nd:YAG laser irradiation, and to evaluate its side effects on the cornea.

MATERIAL AND METHODS

The experiment involved 6 autopsy samples of human posterior lens capsule with different optical and mechanical properties, which were exposed to laser irradiation. We used the Nd:YAG ophthalmic laser LPULSA SYL-9000 Premio manufactured by «LightMed» (Taiwan/USA) and an experimental Nd:YAG laser system (1.064 μm). The following parameters were compared: the power of the incident radiation and radiation transmitted through the PLC, the mechanical stresses in the PLC tissue, the kinetic energy of the laser ablation products, and the pressure of gas bubbles during laser exposure in capsule samples of different densities. In the clinical part of the work, the negative effects of Nd:YAG laser on the cornea at different PLC densities were assessed using the endothelial microscope SP 3000P («Topcon», Japan).

RESULTS

The experiment showed that in hard samples of PLC there are star-shaped point perforations with a diameter of 50±20 μm with partial rarefaction around the point defects. Damage to soft PLC samples in the form of large complete perforations was up to 200 µm in size. The temperature of laser irradiation necessary to achieve breakdown in soft PLC samples was 90 °C, in hard samples — 120 °C. The results of the experiment indicate that the final outcome — destruction of the PLC tissue — is safer to achieve not by increasing the energy, but by increasing the number of laser pulses. Clinical study results confirm a significant effect of the density of PLC on the values of laser energy and on the state of the cornea after laser intervention.

CONCLUSION

The experimental data on the mechanisms of laser destruction of the lens capsule should contribute to the development of new and improvement of already known technologies aimed at reducing the risks associated with laser surgeries.

Keywords:

Nd:YAG laser
lens capsule
secondary cataract
cornea

Authors:

Yusef Yu.N.

Krasnov Research Institute of Eye Diseases;
I.M. Sechenov First Moscow State Medical University (Sechenov University)

Gamidov A.A.

Krasnov Research Institute of Eye Diseases

Baum O.I.

Institute of Photonic Technologies of the Crystallography and Photonics Research Center

Yuzhakov A.V.

Institute of Photonic Technologies of the Crystallography and Photonics Research Center

Medvedeva E.P.

Krasnov Research Institute of Eye Diseases

Kasianenko E.M.

Institute of Photonic Technologies of the Crystallography and Photonics Research Center

Received:

27.03.2022

Accepted:

04.05.2022

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References:

  1. Steinert RF, Puliafito CA, Kumar SR, Dudak SD, Patel S. Cystoid macular edema, retinal detachment, and glaucoma after Nd:YAG laser posterior capsulotomy. Am J Ophthalmol. 1991;112(3):373-380.  https://doi.org/10.1016/s0002-9394(14)76242-7
  2. Gamidov AA, Sosnovskiy VV, Boyev VI, Buzykanova MA. Study of risk factors of laser irradiation-induced intraocular lens damage. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2006;122(5):28-31. (In Russ.). https://www.elibrary.ru/item.asp?id=23836449
  3. Meyer KT, Pettit TN, Staasma BR. Corneal endothelial demage with neodimium: YAG laser. Ophthalmology. 1984;91(9):1022-1028. https://doi.org/10.3928/1542-8877-20000901-09
  4. Holzhey A, Sonntag S, Rendenbach J, Ernesti JS, Kakkassery V, Grisanti S, Reinholz F, Freidank S, Vogel A, Ranjbar M. Development of a noninvasive, laser-assisted experimental model of corneal endothelial cell loss. J Vis Exp. 2020;24(158). https://doi.org/10.3791/60542
  5. Marraffa M, Marchini G, Pagliarusco A, Bonomi L. Ultrasound biomicroscopy and corneal endothelium in Nd:YAG-laser iridotomy. Ophthalm Surg Laser. 1995;26(6):519-523.  https://doi.org/10.1016/B978-0-7020-5193-7.00016-9
  6. Ozturk Y, Göktas E, Calli U. Corneal Endothelial Changes Following Nd:YAG Laser Capsulotomy in Patients with Dense Posterior Capsular Opacification. Turkiye Klinikleri J Ophthalmol. 2019;28(2):75-79.  https://doi.org/10.5336/ophthal.2018-62184
  7. Menda SA, Palay D, McLeod S. Endothelial circles after Nd:YAG posterior capsulotomy. JAMA Ophthalmol. 2015;133(2):220-222.  https://doi.org/10.1001/jamaophthalmol.2014.4289
  8. Gamidov AA, Bol’shunov AV. Lazernaya mikrokhirurgiya zrachkovykh membran. Illyustrirovannoye rukovodstvo [Laser microsurgery of pupillary membranes. Illustrated guide]. M.: Pamyatniki istoricheskoy mysli; 2008;69. (In Russ.). https://search.rsl.ru/ru/record/01004047327
  9. Teshigawara T, Meguro A, Mizuki N. Nd:YAG laser accidentally hitting the corneal layers during treatment of posterior capsule opacification after cataract surgery and its postoperative process. Int Med Case Rep J. 2020;13:449-453.  https://doi.org/10.2147/IMCRJ.S271669
  10. Bailey L, Donzis PB, Kastl PR. Stromal corneal scar following YAG capsulotomy. Ann Ophthalmol. 1988;20(5):188-190.  https://pubmed.ncbi.nlm.nih.gov/3408082/
  11. Khreish M, Hanna R, Berkovitz L, Tiosano B. Corneal perforation after Nd:YAG capsulotomy: A case report and literature review. Case Rep Ophthalmol. 2019;10(1):111-115.  https://doi.org/10.1159/000499178
  12. Kubravi SH, Qureshi ST, Kawoosa K. A case report of corneal tunnel abscess following Nd-YAG laser capsulotomy. J Evolution Med Dent Sci. 2017; 6(56):4217-4218. https://doi.org/10.14260/jemds/2017/914
  13. Lin ZD, Yang WH, Liu YZ. Complications following Nd:YAG laser posterior capsulotomy. Zhonghua Yan Ke Za Zhi. 1994;30(5):325-327.  https://pubmed.ncbi.nlm.nih.gov/7805529/
  14. DeBacker CM, El-Naggar S, Sugar J, Lai WW. Effect of neodymium: YAG laser posterior capsulotomy on corneal grafts. Cornea. 1996;15(1):15-17.  https://doi.org/10.1097/00003226-199601000-00004
  15. Popp J, Tuchin VV, Chiou A, Heinemann SH. Handbook of Biophotonics, vol. 3: Photonics in Pharmaceutics, Bioanalysis and Environmental Research, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 2012;304. 
  16. Yuzhakov AV, Sviridov AP, Shcherbakov EM, Baum OI, Sobol’ EN. Optical properties of costal cartilage and their variation in the process of non-destructive action of laser radiation with the wavelength 1.56 μm. Quantum Electronics = Kvantovaya elektronika. 2014;44(1):65-68. (In Russ.). https://doi.org/10.1070/QE2014v044n01ABEH015343
  17. Sobol E, Serafetinides AA, Makropoulou MI, Helidonis E, Kavvalos G. Hard tissue laser ablation mechanisms. J Lasers Med Sci. 1995;10(3):173-179.  https://doi.org/10.1007/bf02133328
  18. Antonchik SL. Temperature characteristics of the organ of vision in persons older than 40 years, depending on gender. In: Materialy mezhdunarodnogo simpoziuma «Meditsina i okhrana zdorov’ya» [Proceedings of the International Symposium «Medicine and Health Protection»]. Tjumen’. 2002;152. (In Russ.).
  19. Babichev AP, Babushkina NA, Bratkovskij AM, et al. Fizicheskie velichiny [Physical quantities]. M.: Energoatomizdat; 1991;1232. (In Russ.). https://www.internet-biblioteka.ru/217-fizicheskie-velichiny.html
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