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Shilova N.F.

S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Anisimova N.S.

A.I. Yevdokimov Moscow State University of Medicine and Dentristy

Antonova O.P.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”

Anisimov S.I.

A.I. Yevdokimov Moscow State University of Medicine and Dentristy

Malyugin B.E.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Comparative study of corneal densitometry values after posterior lamellar keratoplasty

Authors:

Shilova N.F., Anisimova N.S., Antonova O.P., Anisimov S.I., Malyugin B.E.

More about the authors

Journal: Russian Annals of Ophthalmology. 2020;136(5): 25‑31

DOI: 10.17116/oftalma202013605125

Views: 1921

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To cite this article:

Shilova NF, Anisimova NS, Antonova OP, Anisimov SI, Malyugin BE. Comparative study of corneal densitometry values after posterior lamellar keratoplasty. Russian Annals of Ophthalmology. 2020;136(5):25‑31. (In Russ.)
https://doi.org/10.17116/oftalma202013605125

Подписка 2025 (Russian Annals of Ophthalmology)
 
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Studying clinical and functional outcomes of femtosecond laser-assisted posterior lamellar keratoplasty is an actual problem in endothelial keratoplasty.

PURPOSE

To compare the values of corneal densitometry (CD) as measured by the Scheimpflug camera (Pentacam) following femtosecond laser-assisted Descemet stripping endothelial keratoplasty (DSEK) vs microkeratome-assisted Descemet Stripping Automated Endothelial Keratoplasty (DSAEK).

MATERIAL AND METHODS

The prospective single center randomized study included 37 eyes of 37 patients with Fuchs endothelial dystrophy and cataract. 20 patients underwent cataract phacoemulsification combined with Femto-DSEK; 17 patients of the control group underwent cataract phacoemulsification combined with DSAEK. Outcome measurements included optical coherence tomography of the anterior segment of the eye, endothelial microscopy and densitometry. Optical density of the cornea and its various layers: anterior layer (AL), central layer (CL), posterior layer (PL) and interface zone was assessed in the 0—2 and 2—6 mm zones. The follow-up period lasted 1 year.

RESULTS

Comparative analysis did not reveal statistically significant differences in AL, CL, and CCT values between the groups (p>0.05). In the Femto-DSEK group, densitometry indices of the posterior layers of the cornea and the interface zone were significantly higher than in the DSAEK group (p<0.05). Postoperative uncorrected visual acuity (UCVA) and best corrected visual acuity (BCVA) differed significantly throughout all follow-up period with DSAEK group having better results (p<0.05). Endothelial cell density (ECD) at 12 months was higher in the Femto-DSEK group compared with the DSAEK group (65.7±7.7% and 58.5±8.1%, p=0.02, respectively).

CONCLUSION

After one year, corneal density values (AL, CL, PL) and CCT were comparable between the groups. UCVA, BSCVA and ECD were significantly better after DSAEK.

Keywords:

densitometry
DSEK
microkeratome
femtosecond laser

Authors:

Shilova N.F.

S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Anisimova N.S.

A.I. Yevdokimov Moscow State University of Medicine and Dentristy

Antonova O.P.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”

Anisimov S.I.

A.I. Yevdokimov Moscow State University of Medicine and Dentristy

Malyugin B.E.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Received:

11.12.2019

Accepted:

18.02.2020

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