The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Smirnova T.V.

Krasnov Research Institute of Eye Diseases

Kozlovskaya N.L.

Peoples’ Friendship University of Russia

Sheludchenko V.M.

Krasnov Research Institute of Eye Diseases

Budzinskaya M.V.

Krasnov Research Institute of Eye Diseases

Optical coherence tomography angiography in the diagnosis of retinal microangiopathy in atypical hemolytic-uremic syndrome (a case report)

Authors:

Smirnova T.V., Kozlovskaya N.L., Sheludchenko V.M., Budzinskaya M.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2020;136(4): 226‑234

DOI: 10.17116/oftalma2020136042226

Read: 2451 times

Download PDF (RU)
Contact the author
Table of contents

OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN THE DIAGNOSIS OF RETINAL MICROANGIOPATHY IN ATYPICAL HEMOLYTIC-UREMIC SYNDROME (A CASE REPORT)
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN THE DIAGNOSIS OF RETINAL MICROANGIOPATHY IN ATYPICAL HEMOLYTIC-UREMIC SYNDROME (A CASE REPORT)

To cite this article:

Smirnova TV, Kozlovskaya NL, Sheludchenko VM, Budzinskaya MV. Optical coherence tomography angiography in the diagnosis of retinal microangiopathy in atypical hemolytic-uremic syndrome (a case report). Russian Annals of Ophthalmology. 2020;136(4):226‑234. (In Russ.)
https://doi.org/10.17116/oftalma2020136042226

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Choroidal neovascularization asso­ciated with choroidal nevi. Russian Annals of Ophthalmology. 2025;(1):104-112
Predictive mode­ling of glaucomatous optic neuropathy progression rate in patients with newly diagnosed early primary open-angle glaucoma. Russian Annals of Ophthalmology. 2025;(2):22-29
Abstract:

The article describes a clinical case of acute macular neuroretinopathy and «chronic» paracentral acute middle maculopathy in a patient with atypical hemolytic-uremic syndrome — an orphan disease characterized by systemic thrombosis in the vessels of the microcirculatory bed due to chronic uncontrolled activation of the alternative complement pathway. Optical coherence tomography angiography data confirm the ischemic nature of the disease with localization in the deep vascular plexus of the retina in acute macular neuroretinopathy and in the superficial vascular plexus of the retina in «chronic» paracentral acute middle maculopathy. The use of modern diagnostic methods, including optical coherence tomography angiography, can help improve detection of the pathology and expand its understanding in severe microangiopathic syndromes, which include atypical hemolytic-uremic syndrome.

Keywords:

acute macular neuroretinopathy
paracentral acute middle maculopathy
optical coherence tomography angiography
atypical hemolytic-uremic syndrome
thrombotic microangiopathy
Purtscher-like retinopathy

Authors:

Smirnova T.V.

Krasnov Research Institute of Eye Diseases

Kozlovskaya N.L.

Peoples’ Friendship University of Russia

Sheludchenko V.M.

Krasnov Research Institute of Eye Diseases

Budzinskaya M.V.

Krasnov Research Institute of Eye Diseases

Received:

22.05.2020

Accepted:

30.05.2020

Close metadata

References:

  1. Sarraf D, Rahimy E, Fawzi AA, Sohn E, Barbazetto I, Zacks DN, Mittra RA, Klancnik JM Jr, Mrejen S, Goldberg NR, Beardsley R, Sorenson JA, Freund KB. Paracentral acute middle maculopathy: A new variant of acute macular neuroretinopathy associated with retinal capillary ischemia. JAMA Ophthalmology. 2013;131(10):1275-1287. https://doi.org/10.1001/jamaophthalmol.2013.4056
  2. Chen X, Rahimy E, Sergott RC, Nunes RP, Souza EC, Choudhry N, Cutler NE, Houston SK, Munk MR, FawziAA, Mehta S, Hubschman JP, Ho AC, Sarraf D. Spectrum of retinal vascular diseases associated with paracentral acute middle maculopathy. American Journal of Ophthalmology. 2015; 160(1):26-34.  https://doi.org/10.1016/j.ajo.2015.04.004
  3. Sridhar J, Shahlaee A, Rahimy E, Hong BK, Khan MA, Maguire JI, Dunn JP, Mehta S, Ho AC. Optical coherence tomography angiography and en face optical coherence tomography features of paracentral acute middle maculopathy. American Journal of Ophthalmology. 2015;160(6):1259-1268. https://doi.org/10.1016/j.ajo.2015.09.016
  4. Chu S, Nesper PL, Soetikno BT, Bakri SJ, Fawzi AA. Projection-resolved OCT angiography of microvascular changes in paracentral acute middle maculopathy and acute macular neuroretinopathy. Investigative Ophthalmology and Visual Science. 2018;59(7):2913-2922. https://doi.org/10.1167/iovs.18-24112
  5. Gediz BS. Acute macular neuroretinopathy in Purtscher retinopathy. Turkish Journal of Ophthalmology. 2020;50(2):123-126.  https://doi.org/10.4274/tjo.galenos.2019.02488
  6. Nemiroff J, Phasukkijwatana N, Sarraf D. Optical coherence tomography angiography of deep capillary ischemia. Developments in Ophthalmology. 2016;56:139-145.  https://doi.org/10.1159/000442806
  7. Rahimy E, Kuehlewein L, Sadda SR, Sarraf D. Paracentral acute middle maculopathy what we knew then and what we know now. Retina. 2015;35(10): 1921-1930. https://doi.org/10.1097/IAE.0000000000000785
  8. Shah D, Saurabh K, Roy R. Multimodal imaging in paracentral acute middle maculopathy. Indian Journal of Ophthalmology. 2018;66(8):1186-1188. https://doi.org/10.4103/ijo.IJO_173_18
  9. Kulikov AN, Leongardt TA, Maltsev DS. Optical coherence tomography angiography in paracentral acute middle maculopathy (a case report). Vestnik oftal′mologii. 2018;134(5):72-77. (In Russ.). https://doi.org/10.17116/oftalma201813405172
  10. Weinhaus RS, Burke JM, Delori FC, Snodderly DM. Comparison of fluorescein angiography with microvascular anatomy of macaque retinas. Experimental Eye Research. 1995;61(1):1-16.  https://doi.org/10.1016/S0014-4835(95)80053-0
  11. Soler V, Benouaich X, Mahieu L. Progression of OCT-angiographic signs in paracentral acute middle maculopathy. Journal Francais d’Ophtalmologie. 2017;40(10):405-408.  https://doi.org/10.1016/j.jfo.2016.08.021
  12. Fawzi AA, Pappuru RR, Sarraf D, Le PP, McCannel CA, Sobrin L, Goldstein DA, Honowitz S, Walsh AC, Sadda SR, Jampol LM, Eliott D. Acute macular neuroretinopathy: long-term insights revealed by multimodal imaging. Retina. 2012;32:1500-1513.
  13. Porta A, Tripodi S, Toro MD, Rejdak R, Rejdak K, Zanzottera EC, Ferentini F. Bilateral acute macular neuroretinopathy in a young patient: imaging and visual field during two-year-follow-up. Diagnostics. 2020;10(5):259.  https://doi.org/10.3390/diagnostics10050259
  14. Rahimy E, Sarraf D. Paracentral acute middle maculopathy spectral-domain optical coherence tomography feature of deep capillary ischemia. Current Opinion Ophthalmology. 2014;25(3):207-212.  https://doi.org/10.1097/ICU.0000000000000045
  15. Rahimy E, Sarraf D, Dollin ML, Pitcher JD, Ho AC. Paracentral acute middle maculopathy in nonischemic central retinal vein occlusion. American Journal of Ophthalmology. 2014;158(2):372-380.  https://doi.org/10.1016/j.ajo.2014.04.024
  16. Shahlaee A, Sridhar J, Rahimy E, Shieh WS, Ho AC. Paracentral acute middle maculopathy associated with postviral Purtscher-like retinopathy. Retinal Cases and Brief Reports. 2019;13(1):50-53.  https://doi.org/10.1097/ICB.0000000000000529
  17. Niyousha MR, Hassanpoor N, Eftekhari A, Mousvi F. Simultaneous paracentral acute middle maculopathy and purtscher-like retinopathy after acute febrile illness. Canadian Journal of Ophthalmology. 2018;53(5):184-186.  https://doi.org/10.1016/j.jcjo.2017.11.020
  18. Da Fonseca MLG, Souza A, Pereira MB, Vianna RNG, Cravo LM, Demori E. Paracentral acute middle maculopathy associated with hypoperfusion of the cilioretinal artery and impending central retinal vein occlusion. European Journal of Ophthalmology. 2019;120672119885787. Online ahead of print. https://doi.org/10.1177/1120672119885787
  19. Bakhoum MF, Freund KB, Dolz-Marco R, Leong BCS, Baumal CR, Duker JS, Sarraf D. Paracentral acute middle maculopathy and the ischemic cascade associated with retinal vascular occlusion. American Journal of Ophthalmology. 2018;195:143-15.  https://doi.org/10.1016/j.ajo.2018.07.031
  20. Casalino G, Williams M, McAvoy C, Bandello F, Chakravarthy U. Optical coherence tomography angiography in paracentral acute middle maculopathy secondary to central retinal vein occlusion. Eye (London, England). 2016;30(6):888-893.  https://doi.org/10.1038/eye.2016.57
  21. Arrigo A, Knutsson KA, Rajabian F, Augustin VA, Bandello F, Parodi MB. Combined central retinal vein occlusion and branch retinal artery occlusion treated with intravitreal dexamethasone implant: A case report. European Journal of Ophthalmology. 2020;1120672120909181. Online ahead of print. https://doi.org/10.1177/1120672120909181
  22. Rivera-De La Parra D, Fromov-Guerra J. Paracentral acute middle maculopathy in Purtscher retinopathy. Retinal Cases and Brief Reports. 2020;14(3): 275-277.  https://doi.org/10.1097/ICB.0000000000000696
  23. Miguel AIM, Henriques F, Azevedo LFR, Loureiro AJR, Maberley DAL. Systematic review of Purtscher′s and Purtscher-like retinopathies. Eye (London, England). 2013;27(1):1-13.  https://doi.org/10.1038/eye.2012.222
  24. Yaylali SA, Bromand N, Kilic G. A new OCT finding in Purtscher-like retinopathy. Ophthalmic Surgery, Lasers and Imaging Retina. 2018;49(1):64-69.  https://doi.org/10.3928/23258160-20171215-11
  25. Kozlovskaya NL. Atypical hemolytic uremic syndrome: current understanding of the pathogenesis, clinic, approaches to diagnosis and treatment. Tromboz, Gemostaz I Reologia. 2019;80(4):13-20. (In Russ.). https://doi.org/10.25555/THR.2019.4.0895
  26. Tsai HM. A mechanistic approach to the diagnosis and management of atypical hemolytic uremic syndrome. Transfusion Medicine Reviews. 2014;28(4): 187-197.  https://doi.org/10.1016/j.tmrv.2014.08.004
  27. Sampedro Lopez A, Dominguez Moro B, Baltar Martin JM, Garcia Monteavaro C, Barbon Garcia JJ. Ocular involvement in atypical hemolytic uremic syndrome. Archivos de la Sociedad Espanola de Oftalmolmologia. 2017; 92(12):594-597.  https://doi.org/10.1016/j.oftal.2017.02.007
  28. Sturm V, Menke MN, Landau K, Laube GF, Neuhaus TJ. Ocular involvement in paediatric hemolytic uremic syndrome. Acta Ophthalmologica. 2010; 88(7):804-807.  https://doi.org/10.1111/j.1755-3768.2009.01552.x
  29. Ashraf M, Goldstein D, Fawzi A. Optical coherence tomography angiography: potential artifacts in acute macular neuroretinopathy. JAMA Ophthalmology. 2017;135(6):675-676.  https://doi.org/10.1001/jamaophthalmol.2017.0918
  30. Shah A, Rishi P, Chendilnathan Ch, Kumari S. OCT angiography features of paracentral acute middle maculopathy. Indian Journal of Ophthalmology. 2019;67(3):417-419.  https://doi.org/10.4103/ijo.IJO_1249_18
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.