Optical coherence tomography angiography in the diagnosis of retinal microangiopathy in atypical hemolytic-uremic syndrome (a case report)

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The article describes a clinical case of acute macular neuroretinopathy and «chronic» paracentral acute middle maculopathy in a patient with atypical hemolytic-uremic syndrome — an orphan disease characterized by systemic thrombosis in the vessels of the microcirculatory bed due to chronic uncontrolled activation of the alternative complement pathway. Optical coherence tomography angiography data confirm the ischemic nature of the disease with localization in the deep vascular plexus of the retina in acute macular neuroretinopathy and in the superficial vascular plexus of the retina in «chronic» paracentral acute middle maculopathy. The use of modern diagnostic methods, including optical coherence tomography angiography, can help improve detection of the pathology and expand its understanding in severe microangiopathic syndromes, which include atypical hemolytic-uremic syndrome.

Keywords:

acute macular neuroretinopathy

paracentral acute middle maculopathy

optical coherence tomography angiography

atypical hemolytic-uremic syndrome

thrombotic microangiopathy

Purtscher-like retinopathy

Authors:

Smirnova T.V.

Krasnov Research Institute of Eye Diseases

ORCID: 0000-0001-5137-6786

Kozlovskaya N.L.

Peoples’ Friendship University of Russia

Sheludchenko V.M.

Krasnov Research Institute of Eye Diseases

ORCID: 0000-0001-5958-3018

Budzinskaya M.V.

Krasnov Research Institute of Eye Diseases

SPIN RSCI: 3552-7061
Scopus AuthorID: 6508005851
ResearcherID: C-3026-2014
ORCID: 0000-0002-5507-8775

Received:

22.05.2020

Accepted:

30.05.2020

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