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Serova N.K.

N.N. Burdenko National Medical Research Center of Neurosurgery

Grigoreva N.N.

N.N. Burdenko National Medical Research Center of Neurosurgery

Khavboshina A.G.

N.N. Burdenko National Medical Research Center of Neurosurgery

Butenko E.I.

N.N. Burdenko National Medical Research Center of Neurosurgery

Neuro-ophthalmological symptoms in patients with pineal and suprasellar germinoma

Authors:

Serova N.K., Grigoreva N.N., Khavboshina A.G., Butenko E.I.

More about the authors

Journal: Russian Annals of Ophthalmology. 2020;136(4): 39‑46

DOI: 10.17116/oftalma202013604139

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To cite this article:

Serova NK, Grigoreva NN, Khavboshina AG, Butenko EI. Neuro-ophthalmological symptoms in patients with pineal and suprasellar germinoma. Russian Annals of Ophthalmology. 2020;136(4):39‑46. (In Russ.)
https://doi.org/10.17116/oftalma202013604139

Подписка 2025 (Russian Annals of Ophthalmology)
 
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PURPOSE

To analyze neuro-ophthalmology symptoms in patients with germinomas located in pineal and suprasellar regions.

MATERIAL AND METHODS

The study analyzed 133 patients with germinoma who were receiving treatment in Burdenko Neuro-surgical Institute from 2008 to 2017. Assessment of results was performed by neuro-ophthalmology examination, a computerized oculograph was used for the objectification of the severity of ocular-motor and pupillary disorders.

RESULTS

Among the patients of the study, 65 had pineal germinoma, 42 — suprasellar germinoma and 26 — bifocal germinoma. Among patients with pineal germinomas, males prevailed, while more females had suprasellar germinomas. No statistical difference was found between gender and bifocal germinoma. Pineal germinomas were manifested predominantly by the development of the dorsal midbrain syndrome in the form of oculomotor and pupillary dysfunction (75%) and the development of papilledema (53%). Germinomas of suprasellar localization are most often presented by asymmetric chiasmatic syndrome (24%). Dorsal midbrain syndrome in patients with bifocal germinomas was detected in 76% cases, combination of oculomotor and pupillary dysfunction with visual impairments was found in 38% cases. Neuro-ophthalmological symptoms of germinoma of these regions manifest in the early stages of the disease and require ophthalmological examination during all stages of diagnosis and treatment.

Keywords:

germinoma
pineal region
suprasellar region
oculomotor and pupillary dysfunction
papilledema

Authors:

Serova N.K.

N.N. Burdenko National Medical Research Center of Neurosurgery

Grigoreva N.N.

N.N. Burdenko National Medical Research Center of Neurosurgery

Khavboshina A.G.

N.N. Burdenko National Medical Research Center of Neurosurgery

Butenko E.I.

N.N. Burdenko National Medical Research Center of Neurosurgery

Received:

26.06.2019

Accepted:

30.10.2019

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