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Trufanov S.V.

Research Institute of Eye Diseases

Malozhen S.A.

Krasnov Research Institute of Eye Diseases

Krakhmaleva D.A.

Research Institute of Eye Diseases

Surnina Z.V.

Krasnov Research Institute of Eye Diseases

Pivin E.A.

Research Institute of Eye Diseases

Kasparova E.A.

Krasnov Research Institute of Eye Diseases

Antiangiogenic therapy in high-risk keratoplasty

Authors:

Trufanov S.V., Malozhen S.A., Krakhmaleva D.A., Surnina Z.V., Pivin E.A., Kasparova E.A.

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Journal: Russian Annals of Ophthalmology. 2020;136(4): 11‑18

DOI: 10.17116/oftalma202013604111

Views: 1477

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To cite this article:

Trufanov SV, Malozhen SA, Krakhmaleva DA, Surnina ZV, Pivin EA, Kasparova EA. Antiangiogenic therapy in high-risk keratoplasty. Russian Annals of Ophthalmology. 2020;136(4):11‑18. (In Russ.)
https://doi.org/10.17116/oftalma202013604111

Подписка 2025 (Russian Annals of Ophthalmology)
 
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PURPOSE

To analyze the effectiveness and safety of VEGF inhibitor used to improve keratoconus transplant survival in patients with corneal neovascularization as stand-alone and in combination with laser coagulation of ingrowing vessels before keratoplasty.

MATERIAL AND METHODS

The study included 56 patients (56 eyes) with corneal opacifications of various etiology complicated by corneal neovascularization (CNV). The patients were divided into three groups. The 1st group included 27 patients with diffuse CNV who were undergoing an antiangiogenic therapy using anti-VEGF drug, the 2nd group — 14 patients with stem cell CNV who underwent laser coagulation of major corneal vessels combined with subconjunctival administration of drug before keratoplasty; the control group consisted of 15 patients with mixed type CNV who were undergoing conventional treatment without antiangiogenic therapy.

RESULTS

During the follow-up (24.5±4.84 months, 4 to 25 months), transplant rejection reaction was recorded in 7 (23%) patients of the 1st group, 5 (35%) patients of the 2nd group and 9 (60%) patients of the control group.

CONCLUSION

Subconjunctival administration of Aflibercept as a stand-alone measure and in combination with laser coagulation of ingrowing vessels may increase the chances of transparent transplant acceptance in high-risk keratoplasty.

Keywords:

high-risk keratoplasty
corneal neovascularization
VEGF inhibitor
laser coagulation of ingrowing vessels of the cornea
reaction of transplant rejection

Authors:

Trufanov S.V.

Research Institute of Eye Diseases

Malozhen S.A.

Krasnov Research Institute of Eye Diseases

Krakhmaleva D.A.

Research Institute of Eye Diseases

Surnina Z.V.

Krasnov Research Institute of Eye Diseases

Pivin E.A.

Research Institute of Eye Diseases

Kasparova E.A.

Krasnov Research Institute of Eye Diseases

Received:

07.06.2019

Accepted:

17.12.2019

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