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Safonova T.N.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Zaitseva G.V.

Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021

Loginov V.I.

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315

Burdennyy A.M.

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315

Lukina S.S.

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315;
I.M. Sechenov First Moscow State Medical University, Department of Ophthalmology, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991

Association of polymorphisms of the TRIM21 gene with the severity of dry keratoconjunctivitis in rheumatoid arthritis and Sjogren’s disease

Authors:

Safonova T.N., Zaitseva G.V., Loginov V.I., Burdennyy A.M., Lukina S.S.

More about the authors

Journal: Russian Annals of Ophthalmology. 2019;135(5‑2): 192‑198

DOI: 10.17116/oftalma2019135052192

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Table of contents

ASSOCIATION OF POLYMORPHISMS OF THE TRIM21 GENE WITH THE SEVERITY OF DRY KERATOCONJUNCTIVITIS IN RHEUMATOID ARTHRITIS AND SJOGREN’S DISEASE
ASSOCIATION OF POLYMORPHISMS OF THE TRIM21 GENE WITH THE SEVERITY OF DRY KERATOCONJUNCTIVITIS IN RHEUMATOID ARTHRITIS AND SJOGREN’S DISEASE

To cite this article:

Safonova TN, Zaitseva GV, Loginov VI, Burdennyy AM, Lukina SS. Association of polymorphisms of the TRIM21 gene with the severity of dry keratoconjunctivitis in rheumatoid arthritis and Sjogren’s disease. Russian Annals of Ophthalmology. 2019;135(5‑2):192‑198. (In Russ.)
https://doi.org/10.17116/oftalma2019135052192

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Ophthalmologic manifestation of Sjogren’s disease (SD) and rheumatoid arthritis (RA) is dry keratoconjunctivitis (dry eye disease; DED). Purpose — to study the relationship of polymorphic markers rs7947461 (C/T), rs915956 (C/T), rs4144331 (C/A) of the TRIM21 gene with the severity of DED in patients with RA and SD. Material and methods. The study included 70 patients with RA (n=27) and SD (n=43). The control group consisted of volunteers without a history of RA or SD (n=35). Alleles of the polymorphic marker C660T rs7947461 of the TRIM21 gene were identified using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method; alleles of the polymorphic marker rs915956 (C/T) and rs4144331 (C/A) of the TRIM21 gene were identified by analyzing DNA melting curves. Results. An association was found between the predisposing genotype (TT) of rs7947461 polymorphic marker and the risk of developing severe DED. The AA genotype of rs4144331 polymorphic marker was found only in severe DED (c2=7.74; OR=17.46, CI95%=1.96—318.38, p=0.02). Conclusion. An association was established between rs7947461 (rs660) and rs4144331 and the risk of developing severe DED.

Keywords:

Sjogren’s disease
rheumatoid arthritis
dry keratoconjunctivitis
polymorphic markers

Authors:

Safonova T.N.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Zaitseva G.V.

Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021

Loginov V.I.

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315

Burdennyy A.M.

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315

Lukina S.S.

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315;
I.M. Sechenov First Moscow State Medical University, Department of Ophthalmology, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991

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