Herpesviral infection as an etiological factor of acute idiopathic optic neuritis

Povaliaeva D.A.

Khabarovsk branch of S. Fyodorov Eye Microsurgery Federal State Institution, 211 Tikhookeanskaia St., Khabarovsk, Russian Federation, 680033

Egorov V.V.

Khabarovsk branch of the Academician S.N. Fyodorov IRTC «Eye Microsurgery», 211 Tikhookeanskaya St., Khabarovsk, Russian Federation, 680033;
Postgraduate Institute for Public Health Workers, 9 Krasnodarskaya St., Khabarovsk, Russian Federation, 680009

Smoliakova G.P.

Khabarovsk branch of S. Fyodorov Eye Microsurgery Federal State Institution, 211 Tikhookeanskaia St., Khabarovsk, Russian Federation, 680033;
Institute of Advanced Training of Health Professionals, 9 Krasnodarskaya St., Khabarovsk, Russian Federation, 680000

Danilova L.P.

Emanova L.P.

Zhajvoronok N.S.

Khabarovsk branch of S. Fyodorov Eye Microsurgery Federal State Institution, 211 Tikhookeanskaia St., Khabarovsk, Russian Federation, 680033

Herpesviral infection as an etiological factor of acute idiopathic optic neuritis

Authors:

Povaliaeva D.A., Egorov V.V., Smoliakova G.P., Danilova L.P., Emanova L.P., Zhajvoronok N.S.

More about the authors

Journal: Russian Annals of Ophthalmology. 2019;135(2): 4‑11

DOI: 10.17116/oftalma20191350214

Downloaded: 55

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Povaliaeva DA, Egorov VV, Smoliakova GP, Danilova LP, Emanova LP, Zhajvoronok NS. Herpesviral infection as an etiological factor of acute idiopathic optic neuritis. Russian Annals of Ophthalmology. 2019;135(2):4‑11. (In Russ.)
https://doi.org/10.17116/oftalma20191350214

Подписка 2025 (Russian Annals of Ophthalmology)

Close metadata

Purpose — to assess the etiological significance of herpesviral infection (HVI) in patients with acute idiopathic optic neuritis (ON) using clinical and laboratory monitoring. Material and methods. Clinical and laboratory examinations were conducted for 10 years and were based on the results of etiological monitoring of 79 patients (85 eyes) with acute idiopathic ON in the period of 2005—2015. Results. During a complex examination of 79 patients with acute idiopathic ON, various infectious pathogens were diagnosed in 75 people (94.9±2.1%). HVI was clearly dominant (69 patients — 87.3±2.4%). These patients were divided into 3 etiological groups. The first group — 34 people with herpesviral monoinfection; the second group — 15 people with mixed viral-viral infections; the third group — 20 people with mixed viral-bacterial infections. In the general population of patients with acute idiopathic ON associated with HVI, herpes simplex virus-1 is the most frequent (by more than 2.5 times), the infections of Epstein—Barr virus and cytomegalovirus were detected less often (p<0.05). Active current HVI in the general group of patients was diagnosed in 58 patients (84%). At the same time, reactivation of chronic infection (79.7%) was noted to be prevalent, while primary acute HVI was diagnosed rarely (4.3%). The remaining 11 patients (16%) had chronic persistent HVI. Conclusion. Clinical and laboratory monitoring of HVI in patients with acute idiopathic ON has shown the etiological role of herpesviruses in its development. Based on a complex of serological markers in enzyme-linked immunoassay reactions of blood serum, it was found that in patients with acute idiopathic ON the frequency of herpesviral infection is 87.3±2.4%. The proportion of active (etiologically significant) herpesviral infection is 84% of the total group. The results of the clinical and laboratory studies are of great practical importance for verification of the etiologic diagnosis and selection of adequate etiopathogenetic therapy in patients with acute idiopathic ON associated with HVI.

Keywords:

idiopathic optic neuritis

herpesviral infection

laboratory monitoring

serological markers

Authors:

Povaliaeva D.A.

Khabarovsk branch of S. Fyodorov Eye Microsurgery Federal State Institution, 211 Tikhookeanskaia St., Khabarovsk, Russian Federation, 680033

Egorov V.V.

Smoliakova G.P.

Danilova L.P.

Emanova L.P.

Zhajvoronok N.S.

Khabarovsk branch of S. Fyodorov Eye Microsurgery Federal State Institution, 211 Tikhookeanskaia St., Khabarovsk, Russian Federation, 680033

List of references:

Nazaryan MG, Arbukhanova PM. Modern aspects of disability due to the eye pathology. Kazanskiy meditsinskiy zhurnal. 2015;96(2):224-226. (In Russ.) https://doi.org/10.17750/kmj2015-224
Libman ES, Shakhova EV. Blindness and disability due to pathology of the organ of vision in Russia. Vestnik oftal’mologii. 2006;1:35-37. (In Russ.)
Neroev VV, Zueva MV, Lysenko VS. Opticheskiy nevrit. Autoimmunnye zabolevaniya v nevrologii. Klinicheskoe rukovodstvo. T. 1. M. 2014. (In Russ.)
Shmidt TE. Differential diagnosis of optical neuritis: literature review. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2012;112(9):5-9. (In Russ.)
Povalyaeva DA, Egorov VV, Smolyakova GP, Danilova LP, Emanova LP. Complex therapy of acute idiopathic optic neuritis. Sovremennye tekhnologii v oftal’mologii. 2015;2(6):161-163. (In Russ.)
Guseva EI, Zavalishina IA, Boyko AN. Rasseyannyy skleroz. M.: Real Taym; 2011. (In Russ.)
Ermakova NA. Common understanding of the pathogenesis of uveitis. RMJ. Klinicheskaya oftal’mologiya. 2003;4:141-143. (In Russ.)
Avetisov SE, Egorova EA, Moshetova LK, Neroev VV, Takhchidi KhP. Oftal’mologiya. Natsional’noe rukovodstvo. M. 2016. (In Russ.)
Kazimirchuk VE, Mal’tsev DV. Recommendations for the treatment of human herpesvirus infections. Ukr. med. chasopis. 2012;5(91):94-106. (In Russ.)
Sdobnikova SV, Troitskaya NA, Surnina ZV, Pateyuk LS. General and ophthalmic manifestations of heresvirus infections. Oftal’mologiya. 2016;13(4):228-234. (In Russ.) https://doi.org/10.18008/1816-5095-2016-4-228-234
Sdobnikova SV, Marchenko NR, Troitskaya NA, Surnina ZV, Pateyuk LS. Features of the clinic, diagnosis and treatment of patients with retinal detachment in acute retinal necrosis. Oftal’mologiya. 2017;14(3):233-239. (In Russ.) https://doi.org/10.18008/1816-5095-2017-3-233-239
Isakov VA, Rybalkin SB, Romancov MG. Gerpesvirusnaya infektsiya cheloveka. Rukovodstvo dlya vrachey. SPb. 2013. (In Russ.)
Kasparova EA, Zaitsev AV, Kasparova EA, Kasparov AA. Microdiathermocoagulation in infectious corneal ulcerstreatment. Oftal’mologiya. 2016;13(3):157-162. (In Russ.) https://doi.org/10.18008/1816-5095-2016-3-157-162
Povalyaeva DA, Egorov VV, Smolyakova GP, Danilova LP, Emanova LP. Results of the study of the etiological structure of idiopathic optical neuritis. Sovremennye tekhnologii v oftal’mologii. 2016;2(10):186-191. (In Russ.)
Povalyaeva DA, Egorov VV, Smolyakova GP, Danilova LP, Emanova LP. Results of etiological monitoring of patients with optic neuritis in the Far Eastern Federal District. Sovremennye tekhnologii v oftal’mologii. 2016;3(11):86-89. (In Russ.)
Kalyuzhin OV, Dikinov ZH, Evsegneeva IV. Immune mechanisms of experimental uveoretinitis. Kurskiy nauchno-prakticheskiy vestnik «Chelovek i ego zdorov’e». 2011;1:153-159. (In Russ.)
Povalyaeva DA, Egorov VV, Smolyakova GP, Danilova LP, Emanova LP. Clinical and immunological aspects of the pathogenesis of infectious-associated optical neuritis. Sovremennye tekhnologii v oftal’mologii. 2016;4(12):177-180. (In Russ.)
Chernakova GM, Arzhimatova GSh, Kleshcheva EA. Herpes viruses in ophthalmology. Vestnik oftal’mologii. 2014;4:127-131. (In Russ.)
Chernakova GM, Arzhimatova GSh, Kleshcheva EA, Semenova TB. Ophthalmoherpes: etiology, clinical picture and treatment prospects (literature review). Terra Medica. 2015;1(79):61-65. (In Russ.)
Kasparov AA, Vorob’eva OK, Kasparova EA. Modern aspects of ophthalmoherpes treatment. Vestnik Rossiyskoy akademii nauk. 2003;2:44-49. (In Russ.)
Ioyleva EE, Krivosheeva MS. Single-sided edema of the optic nerve: features of differential diagnosis. Tavricheskiy mediko-biologicheskiy vestnik. 2013;3(2):166-170. (In Russ.)
Ajavi ShM, Volik EI, Ajavi SM. Modern methods of treatment of posterior uveitis of virus, chlamydia, toxoplasmosis etiology. Kubanskiy nauchnyy meditsinskiy vestnik. 2005;3-4:54-57. (In Russ.)
Klimova RR, Zarochentseva NV, Novikova SV. The effect of immunotherapy on the frequency of detection of markers of viral infections in pregnant women with a history of obstetrical gynecological anamnesis. Voprosy ginekologii, akusherstva i perinatologii. 2012;11(1):25-31. (In Russ.)
Kazmirchuk VE, Mal’tsev DV. Sovremennye metody laboratornoy diagnostiki gerpeticheskikh infektsiy. Chast’ 2. Klinika, diagnostika, lechenie gerpesvirusnykh infektsiy cheloveka: monografiya. K.: Feniks; 2009. (In Russ.)
Obryadina AP, Kopnina EO. Antibodies avidity in the diagnosis of infectious diseases. Laboratornaya diagnostika infektsionnykh zabolevaniy. 2007;4:3-5. (In Russ.)
Klimov VV, Cherevko NA, Denisov AA, Kologrivova EN. Klinicheskaya immunologiya i allergologiya. Uchebno-metodicheskoe posobie. Tomsk. 2008. (In Russ.)
Kalyuzhin OV, Dikinov ZH, Evsegneeva IV. Models of intraocular inflammation. Immunopatologiya, allergologiya, infektologiya. 2011;2:14-19. (In Russ.)

Close metadata