Leber hereditary optic neuropathy

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Leber hereditary optic neuropathy is characterized by bilateral, painless loss of vision in children and young adults (generally up to 25 years old). Since its first description in 1871, the understanding of its etiology and pathogenesis has improved considerably. The article considers Leber neuropathy from the points of view of ophthalmology, neurology and molecular genetics, and presents data on experimental treatment methods, one of which is undergoing clinical trial.

Keywords:

Leber’s disease

mutations in mtDNA

gene therapy methods

Authors:

Mazunin I.O.

Immanuel Kant Baltic Federal University, 14 Nevskogo St., Kaliningrad, Russian Federation, 236016

Volodko N.V.

University of Alberta, 116 St. and 85 Ave., Edmonton, AB, Canada, T6G 2R3

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