The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Miliushina L.A.

FGBU "Institut biologii razvitiia im. N.K. Kol'tsova" RAN, Moskva

Kuznetsova A.V.

FGBU "Institut biologii razvitiia im. N.K. Kol'tsova" RAN, Moskva

Aleksandrova M.A.

FGBU "Institut biologii razvitiia im. N.K. Kol'tsova" RAN, Moskva;
Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova

Experimental models of human retinal degenerations: genetic models

Authors:

Miliushina L.A., Kuznetsova A.V., Aleksandrova M.A.

More about the authors

Journal: Russian Annals of Ophthalmology. 2013;129(2): 76‑80

Read: 1148 times


To cite this article:

Miliushina LA, Kuznetsova AV, Aleksandrova MA. Experimental models of human retinal degenerations: genetic models. Russian Annals of Ophthalmology. 2013;129(2):76‑80. (In Russ.)

Recommended articles:
Animal expe­rimental models in the study of age-dependent cere­bral microangiopathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3-2):57-68

References:

  1. Gusarevich O.G., Fursova A.Zh., Kolosova N.G. Izuchenie vliyaniya Oftan Katakhroma na razvitie makulyarnoi degeneratsii setchatki (eksperimental'noe issledovanie). Ros med zhurn 2003; 4: 4: 186.
  2. Poplinskaya V.A., Stroeva O.G. Elektronno-mikroskopicheskoe i morfometricheskoe issledovanie razvitiya naruzhnykh segmentov fotoretseptornykh kletok u mutantnykh krys Campbell s nasledstvennoi distrofiei setchatki. Izv AN SSSR. Ser. biol. 1990; 1: 5-14.
  3. Bourne M.C., Campbell D.A., Tansley K. Hereditary degeneration of the rat retina. Br J Ophthalmol 1938; 22: 613-623.
  4. Burmeister M., Novak J., Liang M.Y., Basu S., Ploder L., Hawes N.L., Vidgen D. et al. Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation. Nat Genet 1996; 12: 376-384.
  5. Chan F., Bradley A., Wensel T.G., Wilson J.H. Knock-in human rhodopsin-GFP fusions as mouse models for human disease and targets for gene therapy. Proc Natl Acad Sci USA 2004; 101: 9109-9114.
  6. Chen J., Jiang H., Nakayama T. et al. Expression of a C-terminal truncated rhodopsin gene leads to retinal degeneration in transgenic mice. Invest Ophthalmol Vis Sci 1993; 34: S333.
  7. D'Cruz P.M., Yasumura D., Weir J., Matthes M.T., Abderrahim H., LaVail M.M., Vollrath D. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet 2000; 9: 645-651.
  8. Freedman M.S., Lucas R.J., Soni B., von Schantz M., Muñoz M., David-Gray Z., Foster R. Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors. Science 1999; 284: 502-504.
  9. Gal A., Li Y., Thompson D.A., Weir J., Orth U., Jacobson S.G., Apfelstedt-Sylla E., Vollrath D. Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nat Genet 2000; 26: 270-271.
  10. Gorn R.A., Kuwabara T. Retinal damage by visible light. A physiologic study. Arch Ophthalmol 1967; 77: 115-118.
  11. Green E.S., Stubbs J.L., Levine E. Genetic rescue of cell number in a mouse model of microphthalmia: interactions between Chx10 and G1-phase cell cycle regulators. Development 2003; 130: 539-552.
  12. Humphries M.M., Rancourt D., Farrar G.J., Kenna P., Hazel M., Bush R.A., Sieving P.A. et al. Retinopathy induced in mice by targeted disruption of the rhodopsin gene. Nat Genet 1997; 15: 216-219.
  13. Jimenez-Sierra J.M., Ogden T.E., van Boemel G.B. Inherited retinal diseases: A diagnostic guide. St Louis: Mosby 1989; 289.
  14. Jones B.W., Marc R.E. Retinal remodeling during retinal degeneration. Exp Eye Res 2005; 81: 123-137.
  15. Jones B.W., Watt C.B., Frederick J.M., Baehr W., Chen C.K., Lerine E.M., Milam A.H. et al. Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol 2003; 464: 1-16.
  16. Keeler C. Retinal degeneration in the mouse is rodless retina. J Hered 1966; 57: 47-50.
  17. LaVail M.M., Sidman R.L., Gerhardt C.O. Congenic strains of RCS rats with inherited retinal dystrophy. J Hered 1975; 66: 242-244.
  18. Machida S., Kondo M., Jamison J.A., Khan N.W., Kononen L.T., Sugawara T., Bush R.A., Sieving P.A. P23H rhodopsin transgenic rat: correlation of retinal function with histopathology. Invest Ophthalmol Vis Sci 2000; 41: 3200-3208.
  19. Marc R.E., Jones B.W., Watt C.B., Strettoi E. Neural remodeling in retinal degeneration. Prog Retin Eye Res 2003; 22: 607-655.
  20. Pierce E.A. Pathways to photoreceptor cell death in inherited retinal degenerations. BioEssays 2001; 23: 605-618.
  21. Pittler S.J., Keeler C.E., Sidman R.L., Baehr W. PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defect. Proc Natl Acad Sci USA 1993; 90: 9616-9169.
  22. Robb G.W., Amann R.P., Killian G.J. Daily sperm production and epididymal sperm reserves of pubertal and adult rats. J Reprod Fertil 1978; 54: 103-107.
  23. Schwartz S.D., Hubschman J.-P., Heilwell G., Franco-Cardenas V., Pan C.K., Ostrick R.M., Mickunas E. et al. Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet 2012; 379: 9817: 713-720.
  24. Stein L., Roy K., Lei L., Kaushal S. Clinical gene therapy for the treatment of RPE65-associated Leber congenital amaurosis. Expert Opin Biol Ther 2011; 11: 3: 429-439.
  25. Steinberg R., Flannery J., Naash M. et al. Transgenic rat models of inherited retinal degeneration caused by mutant opsin genes. Invest Ophthalmol Vis Sci 1996; 37: S698.
  26. Van Nie R., Ivanyi D., Demant P. A new H-2-linked mutation, rds, causing retinal degeneration in the mouse. Tissue Antigens 1978; 12: 106-108.
  27. Wang T., Milam A.H., Steel G., Valle D. A mouse model of gyrate atrophy of the choroid and retina. Early retinal pigment epithelium damage and progressive retinal degeneration. J Clin Invest 1996; 97: 12: 2753-2762.
  28. Zhang K., Kniazeva M., Han M., Li W., Yu Z., Yang Z., Li Y. et al. A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nat Genet 2001; 27: 89-93.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.