Ways to solve the problem of cross-reactions during immunochromatographic examination of biological objects

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The purpose of this review is to study the causes of cross-reactions of a number of drugs (mebeverine, phenibut, tropicamide, ramipril, metoprolol, phenylephrine, sertraline, chloropyramine and diphenhydramine) during the preliminary stage of laboratory diagnostics by immunochromatographic method and to propose a possible algorithm for solving this problem. Conducting a hair study in order to identify the fact of the use of psychoactive substances will increase the reliability of analytical diagnostics and reduce the likelihood of false positive results of the analysis. The use of a validated method of enzymatic hydrolysis of hair will eliminate unreliable results of the analysis due to the detection of the native molecule of the toxicant, increase the efficiency and accuracy of the diagnostic procedure.

Keywords:

immunochromatography

cross-reactions

metabolism

mebeverine

phenibut

tropicamide

ramipril

metoprolol

phenylephrine

sertraline

chloropyramine

diphenhydramine hydrochloride

hair

enzymatic hydrolysis

Authors:

Vickman P.S.

Saint-Petersburg State Chemical and Pharmaceutical University

Zhuravleva A.S.

Saint-Petersburg State Chemical and Pharmaceutical University

Strelova O.Yu.

Saint-Petersburg State Chemical and Pharmaceutical University

Grebenyuk A.N.

Saint Petersburg State Chemical and Pharmaceutical University

Received:

06.04.2022

Accepted:

13.06.2022

List of references:

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Receiver 06.04.2022

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