Determination of zaleplon and clobazam by high performance liquid chromatography — high resolution tandem mass spectrometry using Orbitrap technology

Kalekin R.A.; Moskaleva N.E.; Barseghyan S.S.; Volkova A.A.; Markin P.A.; Nevmyatova S.R.; Appolonova S.A.

doi:https://doi.org/10.17116/sudmed20226502124

Kalekin R.A.

Russian Center of Forensic Medical Examination;
Peoples’ Friendship University of Russia

ORCID: 0000-0002-4989-3511

Moskaleva N.E.

Russian Center of Forensic Medical Expertise;
Sechenov First Moscow State Medical University

Barseghyan S.S.

Russian Center of Forensic Medical Examination;
Peoples’ Friendship University of Russia

ORCID: 0000-0002-9882-2330

Volkova A.A.

Russian Center of Forensic Medical Examination

ORCID: 0000-0002-5419-1418

Markin P.A.

Russian Center of Forensic Medical Expertise;
Sechenov First Moscow State Medical University

Nevmyatova S.R.

Sechenov University

Appolonova S.A.

Russian Center of Forensic Medical Expertise;
Sechenov First Moscow State Medical University

Determination of zaleplon and clobazam by high performance liquid chromatography — high resolution tandem mass spectrometry using Orbitrap technology

Authors:

Kalekin R.A., Moskaleva N.E., Barseghyan S.S., Volkova A.A., Markin P.A., Nevmyatova S.R., Appolonova S.A.

More about the authors

Journal: Forensic Medical Expertise. 2022;65(2): 24‑28

DOI: 10.17116/sudmed20226502124

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To cite this article:

Kalekin RA, Moskaleva NE, Barseghyan SS, Volkova AA, Markin PA, Nevmyatova SR, Appolonova SA. Determination of zaleplon and clobazam by high performance liquid chromatography — high resolution tandem mass spectrometry using Orbitrap technology. Forensic Medical Expertise. 2022;65(2):24‑28. (In Russ.)
https://doi.org/10.17116/sudmed20226502124

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)

Использование инфографики авторами научных работ

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THE AIM OF THE STUDY

Was to develop a method for the qualitative and quantitative determination of benzodiazepine receptor agonists (zaleplon and clobazam), taking into account different chemical structures, by high-performance liquid chromatography-high-resolution tandem mass spectrometry using Orbitrap technology for the purposes and tasks of forensic medical examination. A method has been developed for the identification and quantitative determination of zaleplon and clobazam by high-performance liquid chromatography-high-resolution tandem mass spectrometry using Orbitrap technology. The proposed identification method can be used in the future to form a database of domestic mass spectra for potent and narcotic substances.

Keywords:

zaleplon

clobazam

forensic chemical research

high-performance liquid chromatography

Orbitrap technology

Authors:

Kalekin R.A.

Russian Center of Forensic Medical Examination;
Peoples’ Friendship University of Russia

ORCID: 0000-0002-4989-3511

Moskaleva N.E.

Russian Center of Forensic Medical Expertise;
Sechenov First Moscow State Medical University

Barseghyan S.S.

Russian Center of Forensic Medical Examination;
Peoples’ Friendship University of Russia

ORCID: 0000-0002-9882-2330

Volkova A.A.

Russian Center of Forensic Medical Examination

ORCID: 0000-0002-5419-1418

Markin P.A.

Russian Center of Forensic Medical Expertise;
Sechenov First Moscow State Medical University

Nevmyatova S.R.

Sechenov University

Appolonova S.A.

Russian Center of Forensic Medical Expertise;
Sechenov First Moscow State Medical University

Received:

29.06.2021

Accepted:

21.07.2021

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References:

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Recevied 29.06.2021