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Berezovskiy D.P.

I.M. Sechenov First Moscow State Medical University under the Ministry of Health of Russia (Sechenov University)

Fedulova M.V.

Russian Center for Forensic Medical Examination

Gornostaev D.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
Bureau of Forensic Medical Expertise

Avanesyan H.A.

Stavropol State Medical University

Borschevskaya V.N.

Stavropol State Medical University

Pigolkin Yu.I.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Morphofunctional characteristics of the heart in sudden death of children under 1 year of age in the forensic medical aspect

Authors:

Berezovskiy D.P., Fedulova M.V., Gornostaev D.V., Avanesyan H.A., Borschevskaya V.N., Pigolkin Yu.I.

More about the authors

Journal: Forensic Medical Expertise. 2022;65(2): 5‑8

DOI: 10.17116/sudmed2022650215

Views: 1299

Downloaded: 39

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Table of contents

MORPHOFUNCTIONAL CHARACTERISTICS OF THE HEART IN SUDDEN DEATH OF CHILDREN UNDER 1 YEAR OF AGE IN THE FORENSIC MEDICAL ASPECT
MORPHOFUNCTIONAL CHARACTERISTICS OF THE HEART IN SUDDEN DEATH OF CHILDREN UNDER 1 YEAR OF AGE IN THE FORENSIC MEDICAL ASPECT

To cite this article:

Berezovskiy DP, Fedulova MV, Gornostaev DV, Avanesyan HA, Borschevskaya VN, Pigolkin YuI. Morphofunctional characteristics of the heart in sudden death of children under 1 year of age in the forensic medical aspect. Forensic Medical Expertise. 2022;65(2):5‑8. (In Russ.)
https://doi.org/10.17116/sudmed2022650215

Подписка 2025-2 (Forensic Medical Expertise)
 
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The aim of this study is to describe the morphological and functional characteristics of the cardiac in sudden infants death syndrome (SIDS) in children under one year of age. Twenty eight cases of SIDS were studied histologically and immunohistochemically. Histological examination of the sectional material was carried out using standard and additional stains. The study of cardiac muscle tissue with routine staining with haematoxylin-eosin revealed interstitial oedema, uneven plethora of blood vessels: dystonia and weak plethora of part of the coronary arteries, excess of red blood cells in the veins as well as microcirculatory plethora with stasis of the erythrocytes. An immunohistochemical study revealed a mild over expression of p53 in cellular elements, small-focal expression of CD68 in cardiomyocytes apoptosis intramural areas, activation of mast cells (CD117), expression of ki-67 in macrophages, proliferation of fibroblasts. Additional forensic criteria for the diagnosis of SIDS were determined in the form of atrial endocardial fibrosis and interventricular septum; the expression of CD68, CD117 in fibroblasts, mast cells and lymphocytes; apoptosis of cardiomyocytes (expression of p53), proliferation of fibroblasts and remodeling of the heart (expression of ki-67).

Keywords:

sudden infant death syndrome
forensic medical examination
CD117
CD68
ki-67
p53

Authors:

Berezovskiy D.P.

I.M. Sechenov First Moscow State Medical University under the Ministry of Health of Russia (Sechenov University)

Fedulova M.V.

Russian Center for Forensic Medical Examination

Gornostaev D.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
Bureau of Forensic Medical Expertise

Avanesyan H.A.

Stavropol State Medical University

Borschevskaya V.N.

Stavropol State Medical University

Pigolkin Yu.I.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Received:

27.09.2021

Accepted:

12.11.2021

List of references:

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  2. Gabbay U, Carmi D, Birk E, Dagan D, Shatz A, Kidron D. The Sudden Infant Death Syndrome mechanism of death may be a non-septic hyper-dynamic shock. Med Hypotheses. 2019;122:35-40.  https://doi.org/10.1016/j.mehy.2018.10.018
  3. Baruteau AE, Pass RH, Thambo JB, Behaghel A, Le Pennec S, Perdreau E, Combes N, Liberman L, McLeod CJ. Congenital and childhood atrioventricular blocks: pathophysiology and contemporary management. Eur J Pediatr. 2016;175(9):1235-1248. https://doi.org/10.1007/s00431-016-2748-0
  4. Avtandilov GG. Osnovy patologo-anatomicheskoy praktiki: Rukovodstvo. M.: RMAPO; 1994. (In Russ.).
  5. Lifshits AM. Classification and criteria of heart hypertrophy according to the data of separate weighing of its parts. Arh pat. 1979;2:65-72. (In Russ.).
  6. Pigolkin YuI, Iskhizova LN, Gornostaev DV, Chukanova JV, Dolzhansky O.V. Morphometric and immunohistochemical assessment of the circulation of the cerebral cortex in a burn injury. Vestnik sudebnoy meditsiny. 2012;1(1):5-10. (In Russ.).
  7. Zadniprjanyj IV, Tret’jakova OS, Sataeva TP. Perinatal hypoxia as an inducer of cardiomyocyte apoptosis in newborns. Svit meditsiny ta biologii. 2014;10;1(43):169-176. 
  8. Neary MT, Breckenridge RA. Hypoxia at the heart of sudden infant death syndrome? Pediatr Res. 2013;74(4):375-379.  https://doi.org/10.1038/pr.2013.122
  9. Aubrey BJ, Kelly GL, Janic A, Herold MJ, Strasser A. How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death Differ. 2018;25(1):104-113.  https://doi.org/10.1038/cdd.2017.169
  10. Grasmeyer S, Madea B. Myocardial apoptosis and SIDS. Forensic Sci Int. 2015;246:1-5.  https://doi.org/10.1016/j.forsciint.2014.10.045
  11. Frumento G, Zuo J, Verma K, Croft W, Ramagiri P, Chen FE, Moss P. CD117 (c-Kit) Is Expressed During CD8+ T Cell Priming and Stratifies Sensitivity to Apoptosis According to Strength of TCR Engagement. Front Immunol. 2019;10:468.  https://doi.org/10.3389/fimmu.2019.00468
  12. Kaljuzhin VV, Tepljakov AT, Solovcov MA, Kaljuzhina EV, Bespalova ID, Terent’eva NN. Left ventricular remodeling: one or more scenarios? Bjulleten’ sibirskoy meditsiny. 2016;15(4):120-139. (In Russ.).
  13. Pigolkin YuI, Todorov SS, Berezovskiy DP, Kolomoec IA, Oganesjan NS. Forensic medical diagnosis of sudden death of young people on the basis of morphological analysis of the cardiac conduction system. Sudebno-meditsinskaya ekspertiza. 2020;63(5):39-42. (In Russ.). https://doi.org/10.17116/sudmed20206305139
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