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Illarionova E.A.

Irkutsk State Medical University

Chmelevskaya N.V.

Irkutsk Regional Bureau of Forensic Medical Examination

Tsyrenzhapov A.V.

Irkutsk State Medical University

Lazitskaya A.M.

Irkutsk Regional Bureau of Forensic Medicine

Gonchikova Yu.A.

Irkutsk State Medical University

Investigation of the distribution of (±)-N-methyl-3-phenyl-3-(para-trifluoromethyl) phenoxypropylamine hydrochloride in the body of warm-blooded animals

Authors:

Illarionova E.A., Chmelevskaya N.V., Tsyrenzhapov A.V., Lazitskaya A.M., Gonchikova Yu.A.

More about the authors

Journal: Forensic Medical Expertise. 2021;64(1): 34‑37

DOI: 10.17116/sudmed20216401134

Read: 1291 times

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Table of contents

INVESTIGATION OF THE DISTRIBUTION OF (±)-N-METHYL-3-PHENYL-3-(PARA-TRIFLUOROMETHYL) PHENOXYPROPYLAMINE HYDROCHLORIDE IN THE BODY OF WARM-BLOODED ANIMALS
INVESTIGATION OF THE DISTRIBUTION OF (±)-N-METHYL-3-PHENYL-3-(PARA-TRIFLUOROMETHYL) PHENOXYPROPYLAMINE HYDROCHLORIDE IN THE BODY OF WARM-BLOODED ANIMALS

To cite this article:

Illarionova EA, Chmelevskaya NV, Tsyrenzhapov AV, Lazitskaya AM, Gonchikova YuA. Investigation of the distribution of (±)-N-methyl-3-phenyl-3-(para-trifluoromethyl) phenoxypropylamine hydrochloride in the body of warm-blooded animals. Forensic Medical Expertise. 2021;64(1):34‑37. (In Russ.)
https://doi.org/10.17116/sudmed20216401134

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

THE AIM OF THE STUDY

Was to investigate the distribution of (±)-N-methyl-3-phenyl-3-(para-trifluoromethyl) phenoxypropylamine hydrochloride (fluoxetine) in the body of warm-blooded animals. For the experiments, Wistar rats were used. Fluoxetine was isolated from animal organs and bio-liquids by liquid-liquid extraction. Thin layer chromatography, UV spectrophotometry, and high performance liquid chromatography were used for identification and quantification. Techniques for isolating fluoxetine from urine, blood, intestinal contents, kidneys, and liver samples using liquid-liquid extraction are presented. Methods for identification and quantitative determination of fluoxetine in extracts by thin layer chromatography, UV spectrophotometry, and high performance liquid chromatography are described. The greatest amount of fluoxetine was found in the kidneys — 12.94±2.18 mg/100 g, the small intestine with contents — 9.50±1.90 mg/100 g and liver — 9.28±1.37 mg/100 g.

Keywords:

liquid-liquid extraction
solid phase extraction
UV spectrophotometry
high performance liquid chromatography

Authors:

Illarionova E.A.

Irkutsk State Medical University

Chmelevskaya N.V.

Irkutsk Regional Bureau of Forensic Medical Examination

Tsyrenzhapov A.V.

Irkutsk State Medical University

Lazitskaya A.M.

Irkutsk Regional Bureau of Forensic Medicine

Gonchikova Yu.A.

Irkutsk State Medical University

Received:

25.03.2020

Accepted:

14.05.2020

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References:

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  2. Pashina OE, Kokin IV, Kondratenko SN, Gneushev ET. The pharmacokinetics of fluoxetine: a comparative analysis. Farmatsiya. 2007;2:36-37. (In Russ.).
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  5. Shormanov VK, Pugacheva OI, Astashkina AP, Tcatcua EP. The specific features of the distribution of 2,6-di-tret-buthyl-4-methlhydroxybenzole in the organism of the warm-blooded animals. Sudebno-meditsinskaya ekspertiza. 2016;1:29-34. (In Russ.). https://doi.org/10.17116/sudmed201659129-34
  6. Remezova IP, Lazaryan DS, Voronkov AV, Avramenko NS, Maksimenko TI, Sanzhieva DYu. The chemical toxicological analysis of sertindole. Sudebno-meditsinskaya ekspertiza. 2016;1:35-39. (In Russ.). https://doi.org/10.17116/sudmed201659135-39
  7. Knaub NN, Knaub VA, Dautova DD. Opredelenie fluoksetina v biologicheskikh ob»ektakh. Aktual’nye voprosy sudebnoy meditsinyy ekspertnoy praktiki. 2009;15.  https://doi.org/journal.forens-lit.ru/node/186
  8. Lazitskaya AM. Sovershenstvovanie metodov analiza proizvodnykh benzodiazepina i fenilalkilamina: Dis. ... kand. farm. nauk. Ulan-Ude. 2017. (In Russ.).
  9. Lazickaja AM, Chmelevskaja NV, Illarionova EA. Thin-layer chromatography in the analysis of psychotropic agents at combined poisoning. Bjulleten’ VSNC SO RAMN. 2017;2:74-79. (In Russ.).
  10. Lazickaja AM, Illarionova EA. Spectrophotometric analysis of fluoxetine. Sibirskij meditsinskiy zhurnal (Irkutsk). 2016;1:22-25 (In Russ.).
  11. Lazitskaya AM, Chmelevskaya NV, Illarionova EA, Davydov AK. Analysis of combinations of fluoxetine and psychotropic drugs by the method of microcolumn liquid chromatography. Sibirskiy meditsinskiy zhurnal. 2017;3:83-87. (In Russ.). https://doi.org/10.29001/2073-8552-2017-32-3-83-87
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