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Savchuk S.A.

Department of Special Laboratory Investigations, Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Ministry of Health of the Russia, Moscow, Russia, 125284;
Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology of I.M. Sechenov First Moscow State Medical University, Moscow, Russia, 119992

Shestakova K.M.

I.M. Sechenov First Moscow State Medical University, Moscow, Russia;
Verona University, PhD program in nanoscience and advanced technologies, Verona, Italy

Rizvanova L.N.

Nizhnevartovsk Psychoneurological Hospital, Nizhnevartovsk, Russia, 628615

Burmykin D.A.

Bruker Ltd., Moscow, Russia

Ovcharov M.V.

Bruker Ltd., Moscow, Russia

Mesonzhnik N.V.

Laboratory of Pharmacokinetics and Metabolic Analysis, Institute of Pharmacy and Translational Medicine of the Federal State Autonomous Educational Institution of Higher Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, 119991

Appolonova S.A.

Nizhnevartovsk Psychoneurological Hospital, Nizhnevartovsk, Russia, 628615

Fast HPLC-MS/MS screening method for identification of illegal drugs including new psychoactive substances and their metabolites in human urine

Authors:

Savchuk S.A., Shestakova K.M., Rizvanova L.N., Burmykin D.A., Ovcharov M.V., Mesonzhnik N.V., Appolonova S.A.

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Journal: Forensic Medical Expertise. 2020;63(2): 32‑40

DOI: 10.17116/sudmed20206302132

Views: 3214

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Table of contents

FAST HPLC-MS/MS SCREENING METHOD FOR IDENTIFICATION OF ILLEGAL DRUGS INCLUDING NEW PSYCHOACTIVE SUBSTANCES AND THEIR METABOLITES IN HUMAN URINE
FAST HPLC-MS/MS SCREENING METHOD FOR IDENTIFICATION OF ILLEGAL DRUGS INCLUDING NEW PSYCHOACTIVE SUBSTANCES AND THEIR METABOLITES IN HUMAN URINE

To cite this article:

Savchuk SA, Shestakova KM, Rizvanova LN, Burmykin DA, Ovcharov MV, Mesonzhnik NV, Appolonova SA. Fast HPLC-MS/MS screening method for identification of illegal drugs including new psychoactive substances and their metabolites in human urine. Forensic Medical Expertise. 2020;63(2):32‑40. (In Russ.)
https://doi.org/10.17116/sudmed20206302132

Подписка 2025-2 (Forensic Medical Expertise)
 
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Aim of this study was to develop a fast screening method for identification of illegal drugs including new psychoactive substances and their metabolites in human urine by means of liquid chromatography mass-spectrometry HPLC-MS/MS screening method for identification of 138 psychoactive substances in urine was established, validated and tested. High-resolution mass-spectrometry was used for confirmation of the developed approach. The developed method was tested on 50 positive urine samples containing the target compounds, which proved reliability and accuracy of the established screening method.

Keywords:

new psychoactive substances
mass-spectrometry
screening method

Authors:

Savchuk S.A.

Department of Special Laboratory Investigations, Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Ministry of Health of the Russia, Moscow, Russia, 125284;
Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology of I.M. Sechenov First Moscow State Medical University, Moscow, Russia, 119992

Shestakova K.M.

I.M. Sechenov First Moscow State Medical University, Moscow, Russia;
Verona University, PhD program in nanoscience and advanced technologies, Verona, Italy

Rizvanova L.N.

Nizhnevartovsk Psychoneurological Hospital, Nizhnevartovsk, Russia, 628615

Burmykin D.A.

Bruker Ltd., Moscow, Russia

Ovcharov M.V.

Bruker Ltd., Moscow, Russia

Mesonzhnik N.V.

Laboratory of Pharmacokinetics and Metabolic Analysis, Institute of Pharmacy and Translational Medicine of the Federal State Autonomous Educational Institution of Higher Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, 119991

Appolonova S.A.

Nizhnevartovsk Psychoneurological Hospital, Nizhnevartovsk, Russia, 628615

List of references:

  1. Ambach L, Hernández Redondo A, König S, Weinmann W. Rapid and simple LC-MS/MS screening of 64 novel psychoactive substances using dried blood spots. Drug Test Anal. 2014;6(4):367-375. https://doi.org/10.1002/dta.1505
  2. Ambach L, Redondo AH, König S, Angerer V, Schürch S, Weinmann W. Detection and quantification of 56 new psychoactive substances in whole blood and urine by LC MS/MS. Bioanalysis. 2015;7(9):1119-1136. https://doi.org/10.4155/bio.15.48
  3. Beck O, Rausberg L, Al-Saffar Y, Villen T, Karlsson L, Hansson T, Helander A. Detectability of new psychoactive substances, ‘legal highs’, in CEDIA, EMIT, and KIMS immunochemical screening assays for drugs of abuse. Drug Test Anal. 2014;6(5):492-499. https://doi.org/10.1002/dta.1641
  4. Tang MH, Ching CK, Lee CY, Lam YH, Mak TW. Simultaneous detection of 93 conventional and emerging drugs ofabuse and their metabolites in urine by UHPLC-MS/MS. J Chromatogr B. 2014;15:969:272-284. https://doi.org/10.1016/j.jchromb.2014.08.033
  5. Shin M, Ji D, Kang S, Yang W, Choi H, Lee S. Screening of multiple drugs of abuse and metabolites in urine using LC/MS/MS with polarity switching electrospray ionization. Arch Pharm Res. 2014;37(6):760-772. https://doi.org/10.1007/s12272-013-0225-0
  6. Verplaetse R, Decabooter S, Cuypers E, Tytgat J. Screening of Urine and Blood Using Limited Sample Preparation and Information Dependent Acquisition with LC-MS/MS as Alternative for Immunoassays in Forensic Toxicology. J Forensic Toxicol Pharmacol. 2013;2(2):1-8. https://doi.org/10.4172/2325-9841.1000112
  7. Fagiola M, Hahn T, Avella J. Screening of Novel Psychoactive Substances in Postmortem Matrices by Liquid Chromatography—Tandem Mass Spectrometry (LC—MS-MS). J Anal Toxicol. 2018;42(8):562-569. https://doi.org/10.1093/jat/bky050
  8. Al-Saffar Y, Stephanson NN, Beck O. Multicomponent LC —MS/MS screening method for detection of new psychoactive drugs, legal highs, in urine — experience from the Swedish population. J Chromatogr B Analyt Technol Biomed Life Sci. 2013;1:930:112-120. https://doi.org/10.1016/j.jchromb.2013.04.043
  9. Guidance for the Validation of Analytical Methodology and Calibration of Equipment used for Testing of Illicit Drugs in Seized Materials and Biological Specimens. New York. 2009. https://www.unodc.org/documents/scientific/validation_E.pdf
  10. Understanding the synthetic drug market: the NPS factor. Clobal Smart Urdat. 2018;19:3-10. https://www.unodc.org/documents/scientific/Global_Smart_Update_2018
  11. Aldlgan AA, Torrance HJ. Bioanalytical methods for the determination of synthetic cannabinoids and metabolites in biological specimens, Trends in Analytical Chemistry. 2016;80:444-457. https://doi.org/10.1016/j.trac.2016.03.025

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