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Mesonzhnik N.V.

Laboratory of Pharmacokinetics and Metabolic Analysis, Institute of Pharmacy and Translational Medicine of the Federal State Autonomous Educational Institution of Higher Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, 119991

Kuznetsov R.M.

Laboratory of Pharmacokinetics and Metabolic Analysis, Institute of Pharmacy and Translational Medicine of the Federal State Autonomous Educational Institution of Higher Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, 119991

Postnikov P.V.

FSBU Antidoping Center, Moscow, Russia, 105005

Bochkareva N.L.

FSBU Antidoping Center, Moscow, Russia, 105005

Markin P.A.

Laboratory of Pharmacokinetics and Metabolic Analysis, Institute of Pharmacy and Translational Medicine of the Federal State Autonomous Educational Institution of Higher Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, 119991

Kurynina K.O.

Laboratory of Pharmacokinetics and Metabolic Analysis, Institute of Pharmacy and Translational Medicine of the Federal State Autonomous Educational Institution of Higher Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, 119991

Appolonova S.A.

Nizhnevartovsk Psychoneurological Hospital, Nizhnevartovsk, Russia, 628615

Authentication study of the preparation 'Avastin' by means of chemical-toxicological analysis

Authors:

Mesonzhnik N.V., Kuznetsov R.M., Postnikov P.V., Bochkareva N.L., Markin P.A., Kurynina K.O., Appolonova S.A.

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Journal: Forensic Medical Expertise. 2019;62(5): 47‑53

DOI: 10.17116/sudmed20196205147

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Table of contents

AUTHENTICATION STUDY OF THE PREPARATION 'AVASTIN' BY MEANS OF CHEMICAL-TOXICOLOGICAL ANALYSIS
AUTHENTICATION STUDY OF THE PREPARATION 'AVASTIN' BY MEANS OF CHEMICAL-TOXICOLOGICAL ANALYSIS

To cite this article:

Mesonzhnik NV, Kuznetsov RM, Postnikov PV, Bochkareva NL, Markin PA, Kurynina KO, Appolonova SA. Authentication study of the preparation 'Avastin' by means of chemical-toxicological analysis. Forensic Medical Expertise. 2019;62(5):47‑53. (In Russ.)
https://doi.org/10.17116/sudmed20196205147

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Recommended articles:
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Abstract:

Falsification and use of low-quality drugs of biological origin creates a threat to public health. To a greater extent, costly drugs, including bevacizumab, are exposed to similar abuses. Timely determination of cases of forgery or the improper clinical use of monoclonal antibody preparations is one of the necessary measures that can be taken to limit the risks and preserve the health of patients. This paper presents the results of the investigation of the bevacizumab preparation «Avastin», which was withdrawn from ophthalmic clinical practice in the course of the investigation. We compared the qualitative and quantitative composition of the drug samples, which were determined using commonly available methods of chemical and toxicological analysis.

Keywords:

bevacizumab
monoclonal antibodies
biopharmaceuticals
physical and chemical analysis
falsification
authentication of pharmaceutically active substances
HPLC-MS/MS
electrophoresis
UV-Vis

Authors:

Mesonzhnik N.V.

Laboratory of Pharmacokinetics and Metabolic Analysis, Institute of Pharmacy and Translational Medicine of the Federal State Autonomous Educational Institution of Higher Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, 119991

Kuznetsov R.M.

Laboratory of Pharmacokinetics and Metabolic Analysis, Institute of Pharmacy and Translational Medicine of the Federal State Autonomous Educational Institution of Higher Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, 119991

Postnikov P.V.

FSBU Antidoping Center, Moscow, Russia, 105005

Bochkareva N.L.

FSBU Antidoping Center, Moscow, Russia, 105005

Markin P.A.

Laboratory of Pharmacokinetics and Metabolic Analysis, Institute of Pharmacy and Translational Medicine of the Federal State Autonomous Educational Institution of Higher Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, 119991

Kurynina K.O.

Laboratory of Pharmacokinetics and Metabolic Analysis, Institute of Pharmacy and Translational Medicine of the Federal State Autonomous Educational Institution of Higher Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, 119991

Appolonova S.A.

Nizhnevartovsk Psychoneurological Hospital, Nizhnevartovsk, Russia, 628615

Close metadata

References:

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