The specific features of the distribution of 2,4- and 2,6-di--butylhydroxybenzenes on the body of the warm-blooded animals

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Shormanov V.K.

Kurskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Tsatsua E.P.

State budgetary educational institution of higher professional education "Kursk State Medical University", Russian Ministry of Health, Kursk, Russia, 305041

Astashkina A.P.

GBOU VPO "Kurskiĭ gosudarstvennyĭ meditsinskiĭ universitet"

The specific features of the distribution of 2,4- and 2,6-di--butylhydroxybenzenes on the body of the warm-blooded animals

Authors:

Shormanov V.K., Tsatsua E.P., Astashkina A.P.

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Journal: Forensic Medical Expertise. 2019;62(1): 36‑42

DOI: 10.17116/sudmed20196201136

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To cite this article:

Shormanov VK, Tsatsua EP, Astashkina AP. The specific features of the distribution of 2,4- and 2,6-di--butylhydroxybenzenes on the body of the warm-blooded animals. Forensic Medical Expertise. 2019;62(1):36‑42. (In Russ.)
https://doi.org/10.17116/sudmed20196201136

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)

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Abstract:

The present study was designed to elucidate the character of the distribution of 2,4- and 2,6-di-tret-butylhydroxybenzenes (2,4-DTBHOB and 2,6-DTBHOB respectively) in the body of the warm-blooded animals (rats) following the administration of the three-fold LD50 dose into the stomach. Both 2,4-DTBHOB and 2,6-DTBHOB were extracted from the blood and the organs of the perished animals by means of two-fold incubation of the sampled tissues in ethyl acetate with the subsequent purification of the isolates by passing the extracts through a L 40/100 mcm silicagel column using hexane:dioxane (8.5:1.5) for 2,4-DTBHOB and hexane:dioxane (97.5:2.5) for 2,6-DTBHOB as eluants. The compounds of interest were identified and quantified by means of TLC, HPLC, and UV-spectrometry. The study has shown that both 2,4-DTBHOB and 2,6-DTBHOB were present in the organs and blood of the poisoned animals in the unmetabolized form. Their largest amounts (mg/100 g) were found in the contents of the stomach, the small intestines with the contents and in the spleen.

Keywords:

2,4-di-tret-butylhydroxybenzene

2,6-di-tret-butylhydroxybenzene

the distribution in organism

chemical toxicological study

Authors:

Shormanov V.K.

Kurskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Tsatsua E.P.

State budgetary educational institution of higher professional education "Kursk State Medical University", Russian Ministry of Health, Kursk, Russia, 305041

Astashkina A.P.

GBOU VPO "Kurskiĭ gosudarstvennyĭ meditsinskiĭ universitet"

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References:

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