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Tsimbalist N.S.

Peoples’ Friendship University of Russia

Kryuchkova A.V.

Peoples Friendship University of Russia

Ivina A.A.

Peoples’ Friendship University of Russia;
Central Research Institute of Dentistry and Maxillofacial Surgery

Tikhonova K.O.

Peoples Friendship University of Russia

Syomkin V.A.

Federal State Institution Central Research Institute of Dental and Maxillofacial Surgery of Ministry of Health of the Russian Federation

Babichenko I.I.

Peoples’ Friendship University of Russia;
Central Research Institute of Dentistry and Maxillofacial Surgery

Features of expression of GLUT-1 and Ki-67 proteins in various components of mixed variants of ameloblastoma

Authors:

Tsimbalist N.S., Kryuchkova A.V., Ivina A.A., Tikhonova K.O., Syomkin V.A., Babichenko I.I.

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Journal: Stomatology. 2023;102(1): 7‑12

DOI: 10.17116/stomat20231020117

Read: 1645 times

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Table of contents

FEATURES OF EXPRESSION OF GLUT-1 AND KI-67 PROTEINS IN VARIOUS COMPONENTS OF MIXED VARIANTS OF AMELOBLASTOMA
FEATURES OF EXPRESSION OF GLUT-1 AND KI-67 PROTEINS IN VARIOUS COMPONENTS OF MIXED VARIANTS OF AMELOBLASTOMA

To cite this article:

Tsimbalist NS, Kryuchkova AV, Ivina AA, Tikhonova KO, Syomkin VA, Babichenko II. Features of expression of GLUT-1 and Ki-67 proteins in various components of mixed variants of ameloblastoma. Stomatology. 2023;102(1):7‑12. (In Russ.)
https://doi.org/10.17116/stomat20231020117

Подписка 2026 Стоматология (Stomatology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

THE AIM OF THE STUDY

The aim was to study the metabolic and proliferative activity of the components of ameloblastoma of mixed histological structure. To assess the impact of individual components of mixed variants of ameloblastoma on treatment results and the risk of relapse.

MATERIAL AND METHODS

The study included 21 histological specimens of mixed ameloblastoma. To study proliferative and metabolic activity, histological preparations were immunohistochemically stained. To assess the proliferation of tumor components, histological preparations were stained for the presence of antigens to Ki-67, and the level of metabolic activity was assessed by the expression level of the glucose transporter GLUT-1. Statistical analysis was performed using the Mann-Whitney test, statistical significance was determined using the Chi-square test, and correlation analysis was performed using Spearman’s.

RESULTS

Among the samples of mixed ameloblastoma included in the study, a non-uniform distribution of proliferation and intensity of metabolic activity among the components was obtained. So, among all the components, the plexiform and basal cell variants are distinguished by the greatest proliferative activity. The metabolic activity of these components of mixed ameloblastoma is also increased.

CONCLUSIONS

The data obtained allow us to conclude that it is necessary to take into account plexiform and basal cell components of mixed ameloblastoma, as this can affect the effectiveness of treatment and the risk of relapse.

Keywords:

mixed ameloblastoma
GLUT-1
Ki-67

Authors:

Tsimbalist N.S.

Peoples’ Friendship University of Russia

Kryuchkova A.V.

Peoples Friendship University of Russia

Ivina A.A.

Peoples’ Friendship University of Russia;
Central Research Institute of Dentistry and Maxillofacial Surgery

Tikhonova K.O.

Peoples Friendship University of Russia

Syomkin V.A.

Federal State Institution Central Research Institute of Dental and Maxillofacial Surgery of Ministry of Health of the Russian Federation

Babichenko I.I.

Peoples’ Friendship University of Russia;
Central Research Institute of Dentistry and Maxillofacial Surgery

Received:

28.01.2022

Accepted:

14.11.2022

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