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Vasilyev A.V

Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia;

Laboratory of Stem Cell Genetics of the Medical Genetics Research Center, Moscow, Russia;

Peoples' Friendship University of Russia, Moscow, Russia

Kuznetsova V.S.

Research Centre for Medical Genetics;
Central Research Institute of Dentistry and Maxillofacial Surgery

Bukharova T.B.

Research Centre for Medical Genetics

Zagoskin Y.D.

National Research Center "Kurchatov Institute", Moscow, Russia

Leonov G.E.

Research Centre for Medical Genetics, Moscow, Russia

Grigoriev T.E.

NRC «Kurchatov Institute», Moscow, Russia

Chvalun S.N.

National Research Center "Kurchatov Institute", Moscow, Russia

Goldshtein D.V.

Laboratory of Stem Cell Genetics of the Medical Genetics Research Center, Moscow, Russia

Kulakov A.A.

Central Research Institute of Dentistry and Maxillofacial Surgery

Chitosan hydrogels biocompatibility improvement with the perspective of use as a base for osteoplastic materials in dentistry

Authors:

Vasilyev A.V, Kuznetsova V.S., Bukharova T.B., Zagoskin Y.D., Leonov G.E., Grigoriev T.E., Chvalun S.N., Goldshtein D.V., Kulakov A.A.

More about the authors

Journal: Stomatology. 2019;98(6‑2): 12‑18

DOI: 10.17116/stomat20199806212

Read: 3644 times

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Table of contents

CHITOSAN HYDROGELS BIOCOMPATIBILITY IMPROVEMENT WITH THE PERSPECTIVE OF USE AS A BASE FOR OSTEOPLASTIC MATERIALS IN DENTISTRY
CHITOSAN HYDROGELS BIOCOMPATIBILITY IMPROVEMENT WITH THE PERSPECTIVE OF USE AS A BASE FOR OSTEOPLASTIC MATERIALS IN DENTISTRY

To cite this article:

Vasilyev AV, Kuznetsova VS, Bukharova TB, et al. Chitosan hydrogels biocompatibility improvement with the perspective of use as a base for osteoplastic materials in dentistry. Stomatology. 2019;98(6‑2):12‑18. (In Russ.)
https://doi.org/10.17116/stomat20199806212

Подписка 2026 Стоматология (Stomatology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Recommended articles:
Comparative asse­ssment of the abso­rbency of wound dressings used in the remo­val of third molars of the lower jaw. Stomatology. 2026;(1):16-20
Prospective multicenter study of the effe­ctiveness of hemo­static Z-band with chitosan for stopping postpartum hypo­tonic bleeding during cesa­rean section. Russian Bulletin of Obstetrician-Gynecologist. 2025;(6):45-51
Abstract:

Using chitosan as the basis for osteoplastic material, we were dealt with its low biocompatibility. The critical assessment of it is poorly presented in the literature and does not have systematic approaches to solving. The aim of the study was to determine the effect of factors affecting chitosan charge and its free amino groups number on the biocompatibility of hydrogels. Biocompatibility of chitosan compositions were studied in male Wistar rats (n=90). The subcutaneous implantation of chitosan discs and hydrogel caused abundant leukocyte infiltration. The addition of β-glycerophosphate followed by dialysis slightly reduced the inflammatory response. Treatment with a solution of alkali NaOH and NaHCO3 buffer, on the contrary, intensified the inflammatory response. It is confirmed the effect of charged amino groups of chitosan on leukocyte taxis A decrease in the deacetylation degree (DD) of chitosan to 39.0% led to a statistically significant decrease in leukocyte infiltration. Saturation of chitosan hydrogels with PLA granules reduced by 16% the level of leukocyte infiltration, which was supposedly associated with a decrease in the volume of the hydrogel and an increase in the area of its interaction with blood plasma proteins, which reduce the positive charge of chitosan. The most significant reduction in leukocyte infiltration was achieved with a combination of deacetylated to 39.0% chitosan hydrogel with the addition of 16% by weight highly porous PLA granules.

Keywords:

chitosan
hydrogel
biocompatibility
osteoplastic material

Authors:

Vasilyev A.V

Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia;

Laboratory of Stem Cell Genetics of the Medical Genetics Research Center, Moscow, Russia;

Peoples' Friendship University of Russia, Moscow, Russia

Kuznetsova V.S.

Research Centre for Medical Genetics;
Central Research Institute of Dentistry and Maxillofacial Surgery

Bukharova T.B.

Research Centre for Medical Genetics

Zagoskin Y.D.

National Research Center "Kurchatov Institute", Moscow, Russia

Leonov G.E.

Research Centre for Medical Genetics, Moscow, Russia

Grigoriev T.E.

NRC «Kurchatov Institute», Moscow, Russia

Chvalun S.N.

National Research Center "Kurchatov Institute", Moscow, Russia

Goldshtein D.V.

Laboratory of Stem Cell Genetics of the Medical Genetics Research Center, Moscow, Russia

Kulakov A.A.

Central Research Institute of Dentistry and Maxillofacial Surgery

Close metadata

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