The aim of the study was to evaluate clinical efficiency of oral hygiene agents Mexidol Dent (Farmasoft) for prevention of oral mucosa diseases. Eighty-three xerostomia patients (55 female and 28 male) aged 44 to 62 years were included in the study and divided in 4 groups according to oral hygiene agents: toothpaste Mexidol Dent Fito (20 patients), mouthwash Mexidol Dent Professional (23 patients), both toothpaste and mouthwash (21 patients) and control group of 19 patients who were free to choose their own oral hygiene means. After one year of the study in the experimental groups oral mucosa disorders were revealed in 9.6% of cases, which is 2.7 times lower than in control group.