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Shmakov R.G.

Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky, Moscow, Russia

Pyregov A.V.

Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky, Moscow, Russia

Karimova G.N.

Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky, Moscow, Russia

Kovalenko T.S.

Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky, Moscow, Russia

Travkina A.A.

Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky, Moscow, Russia

Budykina T.S.

Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky, Moscow, Russia

Blazhko M.M.

Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky, Moscow, Russia

Chaplygina O.V.

Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky, Moscow, Russia

Klebanova E.E.

Federal State Budgetary Institution «National Medical Research Center of Hematology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Galstyan G.M.

Federal State Budgetary Institution «National Medical Research Center of Hematology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Pshenichnikova O.S.

Federal State Budgetary Institution «National Medical Research Center of Hematology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Kostyuk D.Yu.

Federal State Budgetary Institution «National Medical Research Center of Hematology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Clinical observation of thrombotic thrombocytic purpura (TTP) during pregnancy: an algorithm and life-saving differential diagnosis

Authors:

Shmakov R.G., Pyregov A.V., Karimova G.N., Kovalenko T.S., Travkina A.A., Budykina T.S., Blazhko M.M., Chaplygina O.V., Klebanova E.E., Galstyan G.M., Pshenichnikova O.S., Kostyuk D.Yu.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2026;26(2): 58‑63

DOI: 10.17116/rosakush20262602158

Read: 268 times

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Table of contents

CLINICAL OBSERVATION OF THROMBOTIC THROMBOCYTIC PURPURA (TTP) DURING PREGNANCY: AN ALGORITHM AND LIFE-SAVING DIFFERENTIAL DIAGNOSIS
CLINICAL OBSERVATION OF THROMBOTIC THROMBOCYTIC PURPURA (TTP) DURING PREGNANCY: AN ALGORITHM AND LIFE-SAVING DIFFERENTIAL DIAGNOSIS

To cite this article:

Shmakov RG, Pyregov AV, Karimova GN, et al. Clinical observation of thrombotic thrombocytic purpura (TTP) during pregnancy: an algorithm and life-saving differential diagnosis. Russian Bulletin of Obstetrician-Gynecologist. 2026;26(2):58‑63. (In Russ.)
https://doi.org/10.17116/rosakush20262602158

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathic disorder characterized by severe thrombocytopenia, microangiopathic hemolysis, and multiorgan dysfunction. In obstetric practice, TTP often mimics severe forms of preeclampsia and HELLP syndrome (hemolysis, elevated liver enzymes, thrombocytopenia), leading to diagnostic errors and delays in treatment. This article presents the case of a young primiparous patient who, at 38 weeks of gestation, developed clinical features consistent with HELLP syndrome and was diagnosed with ADAMTS13 deficiency. This allowed for the confirmation of the diagnosis of TTP and prompt modification of treatment.

Keywords:

thrombotic thrombocytopenic purpura
pregnancy
ADAMTS13
HELLP syndrome
preeclampsia
cesarean section
microangiopathy

Authors:

Shmakov R.G.

Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky, Moscow, Russia

Pyregov A.V.

Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky, Moscow, Russia

Karimova G.N.

Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky, Moscow, Russia

Kovalenko T.S.

Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky, Moscow, Russia

Travkina A.A.

Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky, Moscow, Russia

Budykina T.S.

Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky, Moscow, Russia

Blazhko M.M.

Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky, Moscow, Russia

Chaplygina O.V.

Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky, Moscow, Russia

Klebanova E.E.

Federal State Budgetary Institution «National Medical Research Center of Hematology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Galstyan G.M.

Federal State Budgetary Institution «National Medical Research Center of Hematology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Pshenichnikova O.S.

Federal State Budgetary Institution «National Medical Research Center of Hematology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Kostyuk D.Yu.

Federal State Budgetary Institution «National Medical Research Center of Hematology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Received:

20.10.2025

Accepted:

13.01.2026

Close metadata

References:

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