Objective — to determine the diagnostic and predictive value of the thrombodynamics test in identifying the risk of venous thromboses. Subject and methods. The investigation enrolled eighty-six 20- to 77-year-old patients admitted for elective gynecologic surgery, who had a moderate or high risk (according to the Caprini score), for postoperative venous thromboembolic events after abdominal and vaginal operations. The patients were divided into two groups: 1) 46 patients who underwent abdominal surgery; 2) 40 patients who had vaginal surgery. Clinical and laboratory (thrombodynamics test) and instrumental (Doppler ultrasound, radiography, echocardiography, and electrocardiography) studies were performed. Results. In all the patients, preoperative hemostasis was found to be in the hypercoagulation area in terms of the fixed speed indicator of the thrombodynamics test. In these groups of patients, hypercoagulation persisted after surgery. There was hemostatic system normalization after the first dose of low-molecular-weight heparins at the peak of their action; obvious hypocoagulation was noted in patients at high risk for thromboembolic events after abdominal and vaginal surgeries. It is impossible to draw conclusions about the benefits of one of the surgical accesses in minimizing the risk of venous thromboembolic events. Correction of the hemostatic system with low-molecular-weight heparins leads to the shift of the values of the parameter to the region of normal coagulation or to its return to the level seen operatively. Conclusion. The findings may suggest that the risk of venous thromboembolic events is affected by not only the extent of surgery, but also by the status of the hemostatic system at the time of surgery. The use of low-molecular-weight heparins as a component of combination prevention of postoperative venous thromboembolic events is effective and safe in gynecologic patients with a moderate or high risk of their development.