Objective — to optimize pregravid preparation in thrombophilic patients with a history of pregnancy losses, by achieving the optimal whole blood folate level (greater than 906 nmol/l) prior to pregnancy. Subject and methods. A total of 35 thrombophilic patients with a history of one to four pregnancy losses were examined. The patients’ age was 19—38 years (mean age, 29.5±6.1 years). Genetic tests for plasma homocysteine levels and the anticoagulant activity of antithrombin III, protein C, and protein S were carried out to diagnose thrombophilia. The amount of folic acid in the blood serum and whole blood was determined by enzyme immunoassay. Results. The use of folacin at a dose of 10 mg per day in thrombophilic patients with a history of pregnancy losses during pregravid preparation was found to lead to a rapid significant increase in the serum and whole blood levels of folic acid. Different folic-containing drugs may be used to elevate the level of folic acid in the body’s cells. Conclusion. When planning a pregnancy during pregravid preparation, it is advisable for thrombophilic patients with a history of pregnancy losses to achieve the optimal whole blood levels of folates greater than 906 nmol/l in order to prevent poor pregnancy outcomes. The authors declare no conflicts of interest.