Fifty patients aged 18 to 44 years with cervical intraepithelial neoplasia (CIN) grade I-II were examined, treated, and followed up; of them 25 patients received Allokin-alpha therapy in combination with destructive treatments. A control group consisted of 25 patients diagnosed with CIN I-II who received destructive treatments only. All the patients underwent gynecological examination with extended colposcopy, typing of human papillomavirus (HPV) DNA, and quantitative determination of the virus with polymerase chain reaction using the viral load of HPV genotypes before and 3 and 6 months after its course, as well as bacteriological, cytological, and histological studies. It was ascertained that the best treatment results were observed in patients with HPV infection who received combined treatment with destructive techniques in combination with the antiviral agent Allokin-alpha.