The purpose of the investigation was to study the intergenic interactions of genetic markers for thrombophilia, homocysteine metabolic disturbances, and blood pressure regulators in women with a history of obstetric diseases. The investigation included 2 groups of women. A study group comprised 197 women with a history of eclampsia and miscarriage. A control group consisted of 228 women with a normal obstetric history. Molecular genetic tests were carried out to study the 21-allele polymorphism of genes (such as MTHFR, MTR, MTRR, FGB, F2, F5, F7, F13, ITGA2, ITGB3, PAI-1, ADD1, AGT, AGTR1, AGTR2, CYP, GNB, and NOS3). Univariate analysis revealed no statistically significant differences in the spread of alternative genotypes of the genes under study. However, there was a statistically significant higher frequency of a definite combination of genotypes (AGT 704CC, GNB 825CT, NOS3 894GT, and MTR 2756AG) in the group of patients with a history of eclampsia and miscarriage.