Chronic rhinosinusitis treatment is a relevant problem, for there is no universal therapy regimen for this disease. It is necessary to consider mucoactive drugs in addition to antibiotics, topical steroids, and irrigation therapy. Material and methods. A prospective comparative epidemiological study of the clinical outcomes of three treatment regimens for chronic rhinosinusitis was conducted in 317 patients with an exacerbation of moderate uncomplicated chronic rhinosinusitis without polyps. They were all treated according to three regimens: antibiotic therapy; monotherapy with Sinuforte nasal spray; combined therapy with an antibiotic and Sinuforte. Results. Addition of Sinuforte mucoactive spray to standard antibiotic therapy could reduce the number and frequency of chronic sinusitis recurrences by 4 times. When Sinuforte nasal spray was used as monotherapy, the regression of rhinosinusitis symptoms was comparable and, in terms of some indicators, more marked than when antibiotic monotherapy without a mucolytic was performed. Conclusion. Thus, incorporation of the mucoactive drug Sinuforte into a therapy regimen can improve the efficiency of treatment for mild and moderate uncomplicated chronic rhinosinusitis without polyps. Sinuforte may be used as monotherapy if a follow-up is conducted, which allows the need for antibiotic therapy to be reduced.