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Metelskaya V.A.

National Medical Research Center for Therapy and Preventive Medicine;
Russian Medical Academy of Continuous Professional Education

Serum proteomic analysis: role in the search for biomarkers of atherosclerosis

Authors:

Metelskaya V.A.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2022;25(12): 135‑143

DOI: 10.17116/profmed202225121135

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Table of contents

SERUM PROTEOMIC ANALYSIS: ROLE IN THE SEARCH FOR BIOMARKERS OF ATHEROSCLEROSIS
SERUM PROTEOMIC ANALYSIS: ROLE IN THE SEARCH FOR BIOMARKERS OF ATHEROSCLEROSIS

To cite this article:

Metelskaya VA. Serum proteomic analysis: role in the search for biomarkers of atherosclerosis. Russian Journal of Preventive Medicine. 2022;25(12):135‑143. (In Russ.)
https://doi.org/10.17116/profmed202225121135

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The objective of this paper is to review the current literature on the development of microarray technology for proteomic analysis and advances in the search for protein determinants of disorders associated with atherosclerosis.

MATERIAL AND METHODS

The publications were searched in MedLine, PubMed, Scopus, Cochrane Library, and Google Scholar databases by keywords (in Russian and English): proteome, proteomics, microarrays. Only full-text articles published since 2000 were considered; the last search date is July 27, 2022.

RESULTS

Microarrays provide a new platform that enables the detection and characterization of proteins and contributes to the progress in the search for protein determinants of chronic non-communicable diseases, including atherosclerosis-related cardiovascular diseases. Recent developments in proteomics are opening up new opportunities for clinical applications of proteomic analysis, including identifying novel biomarkers, monitoring disease, and detecting drug side effects and environmental hazards. Therefore, clinical proteomics is reasonably considered a new branch of proteomics.

CONCLUSION

Proteomic technologies will make it possible to analyze the molecular composition of biological material to assess the risk of socially significant and occupationally determined diseases and to make an early diagnosis.

Keywords:

proteome
proteomic analysis
microarrays
clinical proteomics

Authors:

Metelskaya V.A.

National Medical Research Center for Therapy and Preventive Medicine;
Russian Medical Academy of Continuous Professional Education

Received:

12.08.2022

Accepted:

21.11.2022

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