The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Chebotareva N.V.

First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)

Sovetnikov E.N.

First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)

Berns A.S.

First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)

Vinogradov A.A.

Sechenov First Moscow State Medical University (Sechenov University)

Lebedeva M.V.

Sechenov First Moscow State Medical University (Sechenov University)

Berns S.A.

National Medical Research Center for Therapy and Preventive Medicine

Moiseev S.V.

First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)

Hemostasis disorders assessed by global tests in patients with chronic glomerulonephritis and nephrotic syndrome

Authors:

Chebotareva N.V., Sovetnikov E.N., Berns A.S., Vinogradov A.A., Lebedeva M.V., Berns S.A., Moiseev S.V.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2022;25(12): 119‑126

DOI: 10.17116/profmed202225121119

Views: 1084

Downloaded: 36

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Chebotareva NV, Sovetnikov EN, Berns AS, Vinogradov AA, Lebedeva MV, Berns SA, Moiseev SV. Hemostasis disorders assessed by global tests in patients with chronic glomerulonephritis and nephrotic syndrome. Russian Journal of Preventive Medicine. 2022;25(12):119‑126. (In Russ.)
https://doi.org/10.17116/profmed202225121119

 
МСФ на ЯМ
Close metadata

Nephrotic syndrome (NS) is associated with a high venous and arterial thrombosis risk. Local hemostasis assessment tests are not informative enough in detecting hypercoagulation states. Global tests to assess blood clotting may be an alternative in patients with NS.

OBJECTIVE

To characterize hemostasis system disorders in patients with chronic glomerulonephritis and NS using global tests — thrombodynamics and thromboelastography (TEG).

MATERIAL AND METHODS

The study included 54 patients (25 [46.3%] females and 29 [53.7%] males) with chronic glomerulonephritis (CGN) before the anticoagulant therapy: 44.4% of patients with NS and 55.6% without NS. The average age of the patients was 41 years. Parameters of hemostasis tests were compared with laboratory indicators of NS and renal dysfunction severity.

RESULTS

According to the thrombodynamics test, abnormal indices indicating hypercoagulation were noted in 31.3% of patients with NS and in 18.2% of patients without NS; according to TEG, hypercoagulation was observed in 50% of patients with NS and 27.3% of those without NS. Patients with NS showed an increase in V (clot growth rate), D (clot density), and CS (clot size) after 30 min. According to TEG results, K (the time (min) between the amplitudes of 2 mm and 20 mm, depends on the level of fibrinogen), MA (reflecting fibrin-platelet interaction), and R parameters (coagulation initiation time) were abnormal in patients with NS, especially in the group with membranous nephropathy. Statistically significant correlations of these parameters with the serum albumin, cholesterol, creatinine level, and estimated glomerular filtration rate were revealed.

CONCLUSION

According to global hemostasis assessment tests, approximately half of patients with chronic glomerulonephritis and nephrotic syndrome have increased plasma readiness for thrombosis. Indices of blood coagulation activation correlate with the severity of hypoalbuminemia, hypercholesterolemia, and renal dysfunction.

Keywords:

blood clotting
nephrotic syndrome
thrombodynamics test
thromboelastography

Authors:

Chebotareva N.V.

First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)

Sovetnikov E.N.

First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)

Berns A.S.

First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)

Vinogradov A.A.

Sechenov First Moscow State Medical University (Sechenov University)

Lebedeva M.V.

Sechenov First Moscow State Medical University (Sechenov University)

Berns S.A.

National Medical Research Center for Therapy and Preventive Medicine

Moiseev S.V.

First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)

Received:

25.07.2022

Accepted:

16.09.2022

List of references:

  1. Bobrova LA, Kozlovskaya NL. Thromboembolic complications of nephrotic syndrome. Terapevticheskij arkhiv. 2020;92(6):105-116. (In Russ.). https://doi.org/10.26442/00403660.2020.06.000667
  2. Lempp S, Schwenger V. Isolated right ventricular thrombus in an adult patient with nephrotic syndrome: A case report. Journal of Medical Case Reports. 2017;11(1):311.  https://doi.org/10.1186/s13256-017-1491-0
  3. Al-Azzawi HF, Obi OC, Safi J, Song M. Nephrotic syndrome-induced thromboembolism in adults. International Journal of Critical Illness and Injury Science. 2016;6(2):85-88.  https://doi.org/10.4103/2229-5151.183019
  4. Mahmoodi BK, ten Kate MK, Waanders F, et al. High Absolute Risks and Predictors of Venous and Arterial Thromboembolic Events in Patients With Nephrotic Syndrome: Results From a Large Retrospective Cohort Study. Circulation. 2008;117(2):224-230.  https://doi.org/10.1161/Circulationaha.107.716951
  5. Zhang LJ, Zhang Z, Li SJ, et al. Pulmonary Embolism and Renal Vein Thrombosis in Patients with Nephrotic Syndrome: Prospective Evaluation of Prevalence and Risk Factors With CT. Radiology. 2014;273(3):897-906.  https://doi.org/10.1148/radiol.14140121
  6. Lin R, McDonald G, Jolly T, Batten A. A Systematic Review of Prophylactic Anticoagulation in Nephrotic Syndrome. Kidney International Reports. 2019;12;5(4):435-447.  https://doi.org/10.1016/j.ekir.2019.12.001
  7. Roy C, Deschaintre Y, Sabbagh R, Roy D, Cardinal H, Bollée G. Ischemic Stroke of Possible Embolic Etiology Associated With Nephrotic Syndrome. Kidney International Reports. 2017;2(5):988-994.  https://doi.org/10.1016/j.ekir.2017.04.004
  8. Huang JA, Lin CH, Chang YT, et al. Nephrotic Syndrome is Associated with Increased Risk of Ischemic Stroke. Journal of Stroke and Cerebrovascular Diseases. 2019;28(11):104322. https://doi.org/10.1016/j.jstrokecerebrovasdis.2019.104322
  9. Kumar S, Chapagain A, Nitsch D, Yaqoob MM. Proteinuria and hypoalbuminemia are risk factors for thromboembolic events in patients with idiopathic membranous nephropathy: An observational study. BMC Nephrology. 2012;13(1):107.  https://doi.org/10.1186/1471-2369-13-107
  10. Lionaki S, Derebail VK, Hogan SL, et al. Venous Thromboembolism in Patients with Membranous Nephropathy. Clinical Journal of the American Society of Nephrology. 2012;7(1):43-51.  https://doi.org/10.2215/CJN.04250511
  11. Singhal R, Brimble KS. Thromboembolic complications in the nephrotic syndrome: pathophysiology and clinical management. Thrombosis Research. 2006:118(3):397-407.  https://doi.org/10.1016/j.thromres.2005.03.030
  12. Yang Y, Lv J, Zhou F, et al. Risk factors of pulmonary thrombosis/embolism in nephrotic syndrome. American Journal of Medical Sciences. 2014: 348(5):394-398.  https://doi.org/10.1097/MAJ.0000000000000315
  13. Panteleev MA, Ataullakhanov FI. Blood coagulation: biochemical basis. Klinicheskaya onkogematologiya. 2008;1(1):50-62. (In Russ.).
  14. Curry ANG, Pierce JMT. Conventional and near-patient tests of coagulation. Continuing Education in Anaesthesia, Critical Care and Pain. 2007; 7(20):45-50.  https://doi.org/10.1093/bjaceaccp/mkm002
  15. Bulanov AYu. Tromboelastografiya v sovremennoj klinicheskoj praktike. Atlas TEG. M.: N’yudiamed; 2015. (In Russ.).
  16. Bellomo R, Atkins RC. Membranous nephropathy and thromboembolism: Is prophylactic anticoagulation warranted? Nephron. 1993;63(3):249-254.  https://doi.org/10.1159/000187205
  17. Orth SR, Ritz E. The nephrotic syndrome. New England Journal of Medicine. 1998;338(17):1202-1211. https://doi.org/10.1056/NEJM199804233381707
  18. Llach F, Koffler A, Finck E, Massry SG. On the incidence of renal vein thrombosis in the nephrotic syndrome. Archives of Internal Medicine. 1977; 137(3):333-336.  https://doi.org/10.1001/ARCHINTE.1977.03630150039012
  19. Yalçinkaya F, Tümer N, Gorgani AN, et al. Haemostatic parameters in childhood nephrotic syndrome. International Urology and Nephrology. 1995;27(5): 643-647.  https://doi.org/10.1007/BF02564753
  20. Sexton DJ, Clarkson MR, Mazur M. et al. Serum D-dimer concentrations in nephrotic syndrome track with albuminuria, not estimated glomerular filtrationrate. American Journal of Nephrology. 2012;36(6):554-560.  https://doi.org/10.1159/000345475
  21. Huang MJ, Wei RB, Wang ZC, et al. Mechanisms of hypercoagulability in nephrotic syndrome associated with membranous nephropathy as assessed by thromboelastography. Thrombosis Research. 2015;136(3):663-668.  https://doi.org/10.1016/j.thromres.2015.06.031
  22. Glassock RG. Prophylactic anticoagulation in nephrotic syndrome: A clinical conundrum. Journal of the American Society of Nephrology. 2007;18(8): 2221-2225. https://doi.org/10.1681/ASN.2006111300
  23. Berns AS, Sovetnikov EN, Chebotareva NV, Berns SA, Solonkina AD, Gulyaev SV, Kraeva VV, Moiseev SV. Evaluation of hemostasis disorders using the thrombodynamic test in patients with chronic glomerulonephritis with nephrotic syndrome. Terapevticheskii arkhiv. 2022;94(6):738-742. (In Russ.). https://doi.org/10.26442/00403660.2022.06.201558
  24. Kumar G, Sakhuja A, Taneja A, et al; Milwaukee Initiative in Critical Care Outcomes Research (MICCOR) Group of Investigators. Pulmonary embolism in patients with CKD and ESRD. Clinical Journal of the American Society of Nephrology. 2012;7(10):1584-1590. https://doi.org/10.2215/CJN.00250112
  25. Singh J, Khadka S, Solanki D, et al. Pulmonary embolism in chronic kidney disease and end-stage renal disease hospitalizations: Trends, outcomes, and predictors of mortality in the United States. SAGE Open Medicine. 2021;9:20503121211022996. https://doi.org/10.1177/20503121211022996
  26. Anand NK, Chand G, Talib VH, et al. Hemostatic profile in neprhortic syndrome. Indian Pediatrics. 1996;33(12):1005-1012.
  27. López-Alemany R, Longstaff C, Hawley S, et al. Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-Enolase. American Journal of Hematology. 2003;72(4):234-242.  https://doi.org/10.1002/ajh.10299
  28. Lu C, Zuo K, Le W, et al. Characterization of thromboelastography of patients with different pathological types of nephrotic syndrome. Medicine. 2020;99(5):e18960. https://doi.org/10.1097/MD.0000000000018960
  29. Owens AP 3rd, Passam FH, Antoniak S, et al. Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. The Journal of Clinical Investigation. 2012; 122(2):558-568.  https://doi.org/10.1172/JCI58969

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.