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Krivoschekov E.P.

Samara State Medical University

Katorkin S.E.

Samara State Medical University

Elshin E.B.

Samara City Clinical Hospital No. 8

Romanov V.E.

Samara State Medical University

Sulodexide in post-hospital treatment of patients with new coronavirus infection COVID-19

Authors:

Krivoschekov E.P., Katorkin S.E., Elshin E.B., Romanov V.E.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2022;25(1): 91‑97

DOI: 10.17116/profmed20222501191

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Table of contents

SULODEXIDE IN POST-HOSPITAL TREATMENT OF PATIENTS WITH NEW CORONAVIRUS INFECTION COVID-19
SULODEXIDE IN POST-HOSPITAL TREATMENT OF PATIENTS WITH NEW CORONAVIRUS INFECTION COVID-19

To cite this article:

Krivoschekov EP, Katorkin SE, Elshin EB, Romanov VE. Sulodexide in post-hospital treatment of patients with new coronavirus infection COVID-19. Russian Journal of Preventive Medicine. 2022;25(1):91‑97. (In Russ.)
https://doi.org/10.17116/profmed20222501191

 
 
Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To search for new effective, pathogenesis-based outpatient treatment methods for patients with new coronavirus infection (COVID-19).

MATERIAL AND METHODS

We examined 130 patients aged 45—75 years with severe COVID-19 and acute viral multisegmental pneumonia with lung tissue involvement of 30 to 63% who had previously received inpatient treatment. The patients were divided into four comparable groups according to the method of outpatient anticoagulant therapy. Group 1 (32 patients) received apixaban 2.5 mg BID for 1 month; Group 2 (32 patients) received apixaban in the same dosage for 6 months; Group 3 (32 patients) received sulodexide at 250 ULS BID and acetylsalicylic acid 100 mg/day for 1 month; Group 4 (34 patients) received sulodexide and acetylsalicylic acid in the same dosage for 6 months. Patients were examined 1, 3 and 6 months after hospital discharge. A comparative efficacy and safety analysis was performed. The criteria were the occurrence/absence of clinically significant thrombosis, changes in the coagulation tests, and the presence/absence of hemorrhagic complications in each of the treatment groups.

RESULTS

Despite the ongoing treatment, venous thrombosis occurred in 18 (13.8%) patients, mostly in the groups that stopped anticoagulant therapy after one month. Changes in coagulation tests (aPTT, INR, PTT, fibrinogen, and platelets) were statistically insignificant, except for a decrease in D-dimer, which was observed in the groups receiving anticoagulant therapy for six months. There was no statistically significant increase in hemorrhagic complications in the groups receiving continuous anticoagulant therapy.

CONCLUSION

The data obtained suggest continuous anticoagulant therapy use (up to 6 months) in patients with severe COVID-19.

Keywords:

COVID-19 convalescents
thrombosis prophylaxis
apixaban
sulodexide
acetylsalicylic acid

Authors:

Krivoschekov E.P.

Samara State Medical University

Katorkin S.E.

Samara State Medical University

Elshin E.B.

Samara City Clinical Hospital No. 8

Romanov V.E.

Samara State Medical University

Received:

31.08.2021

Accepted:

09.12.2021

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