The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Maksimenko L.V.

Peoples’ Friendship University of Russia, Ministry of Science and Higher Education of the Russian Federation, Moscow, Russia

Epigenetics as an evidence base of the impact of lifestyle on health and disease

Authors:

Maksimenko L.V.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2019;22(2): 115‑120

DOI: 10.17116/profmed201922021115

Read: 53826 times

Download PDF (RU)
Contact the author
Table of contents

EPIGENETICS AS AN EVIDENCE BASE OF THE IMPACT OF LIFESTYLE ON HEALTH AND DISEASE
EPIGENETICS AS AN EVIDENCE BASE OF THE IMPACT OF LIFESTYLE ON HEALTH AND DISEASE

To cite this article:

Maksimenko LV. Epigenetics as an evidence base of the impact of lifestyle on health and disease. Russian Journal of Preventive Medicine. 2019;22(2):115‑120. (In Russ.)
https://doi.org/10.17116/profmed201922021115

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Epigenetic regu­lation in the placenta in case of impaired trophoblast inva­sion (a review). Russian Journal of Human Reproduction. 2024;(6):45-54
The role of DNA methylation, histone modi­fications, and non-coding RNA expression in the pathogenesis of premature ovarian insu­fficiency and inno­vative ways to overcome infe­rtility from the point of epigenetic disturbances. Russian Journal of Human Reproduction. 2025;(3):6-19
Embryological mechanisms of sexual orientation and gender identity diso­rders. Russian Journal of Human Reproduction. 2025;(3):34-41
Leukocyte telo­mere length changes following various anesthetic methods in patients with severe combined trauma. Russian Journal of Anesthesiology and Reanimatology. 2025;(5):22-27
Modern methods of reha­bilitation of patients with different degrees of multiple scle­rosis. (Literature review). Problems of Balneology, Physiotherapy and Exercise Therapy. 2025;(5):48-55
Abstract:

Epigenetic mechanisms indirectly encoded in the genome change gene activity in response to lifestyle and environmental factors, from intrauterine development to death. Having intensively developed over the past 30 years, epigenetics discloses the molecular epigenetic basis of the mechanisms of the body’s response to environmental and lifestyle factors. The body’s metabolic changes that occur in the early critical period under the influence of harmful behavioral and environmental factors and result in chronic non-communicable diseases that are the leading causes of death may be corrected by lifestyle modifications in later life periods. Thus, today, epigenetics provides a fundamental basis and offers hope for improvement in health and increases in life expectancy for mankind through preventive measures and hygiene.

Keywords:

epigenetics
lifestyle
environmental factors
life course health development

Authors:

Maksimenko L.V.

Peoples’ Friendship University of Russia, Ministry of Science and Higher Education of the Russian Federation, Moscow, Russia

Close metadata

References:

  1. Vanyushin BF. Epigenetics today and tomorrow. Vavilovskii zhurnal genetiki i selektsii. 2013;17(4/2):805-832. Accessed 04.04.18. (In Russ.) URL: http://www.bionet.nsc.ru/vogis/download/17-4/2/06Vanushin.pdf
  2. Barker DJP. Mothers, Babies, and Health in Later Life. Edinburgh: Churchill Livingstone; 1998. ISBN:0443061653 (pbk.). https://trove.nla.gov.au/work/7976056
  3. Barker DJP. Developmental origins of adult health and disease. Journal of Epidemiology and Community Health. 2004;58:114-115. https://doi.org/10.1136/jech.58.2.114
  4. Lawlor DA, Davey Smith G, Ebrahim S. Birth weight is inversely associated with coronary heart disease in post-menopausal women: findings from the British women’s heart and health study. Journal of Epidemiology & Community Health. 2004;58:120-125. https://doi.org/10.1136/jech.58.2.120
  5. Zheng J, Xiao X, Zhang Q, Yu M. DNA methylation: The pivotal interaction between early-life nutrition and glucose metabolism in later life. British Journal of Nutrition. 2014;112(11):1850-1857. https://doi.org/10.1017/S0007114514002827
  6. Wahlqvist ML, Krawetz SA, Rizzo NS, et al. Early-life influences on obesity: from preconception to adolescence. Annals of the New York Academy of Sciences. 2015;1347:1-28. https://doi.org/10.1111/nyas.12778
  7. Zilbauer M, Zellos A, Heuschkel R, et al. Epigenetics in Paediatric Gastroenterology, Hepatology, and Nutrition: Present Trends and Future Perspectives. Journal of Pediatric Gastroenterology and Nutrition. 2016;62(4):521-529. https://doi.org/10.1097/MPG.0000000000001053
  8. Remely M, de la Garza AL, Magnet U, et al. Obesity: epigenetic regulation – recent observations. Biomolecular Concepts. 2015;6(3):163-175. https://doi.org/10.1515/bmc-2015-0009
  9. Zaiou ME, Amri H, Bakillah A. The clinical potential of adipogenesis and obesity-related microRNAs. Nutrition, Metabolism and Cardiovascular Diseases. 2018 Feb;28(2):91-111. https://doi.org/10.1016/j.numecd.2017.10.015
  10. Baskaran C, Kandemir N. Update on endocrine aspects of childhood obesity. Current Opinion in Endocrinology, Diabetes and Obesity. 2018;Feb;25(1): 55-60. https://doi.org/10.1097/MED.0000000000000381
  11. Rueter K, Prescott SL, Palmer DJ. Nutritional approaches for the primary prevention of allergic disease: An update. Journal of Pediatrics and Child Health. 2015;51(10):962-969;quiz 968-969. https://doi.org/10.1111/jpc.12951
  12. Wang J, Cao M, Yang M, et al. Intra-uterine undernutrition amplifies age-associated glucose intolerance in pigs via altered DNA methylation at muscle GLUT4 promoter. British Journal of Nutrition.2016;116(3):390-401. https://doi.org/10.1017/S0007114516002166
  13. Cai D, Jia Y, Lu J, et al. Maternal dietary betaine supplementation modifies hepatic expression of cholesterol metabolic genes via epigenetic mechanisms in newborn piglets. British Journal of Nutrition.2014;112(9):1459-1468. https://doi.org/10.1017/S0007114514002402
  14. Li D, Tian Y, Guo J, et al. Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats. British Journal of Nutrition.2013;110(12):2156-2164. https://doi.org/10.1017/S0007114513001815
  15. Tian Y, Luo N, Chen N, et al. Maternal nicotinamide supplementation causes global DNA hypomethylation, uracil hypo-incorporation and gene expression changes in fetal rats. British Journal of Nutrition.2014;111(9):1594-1601. https://doi.org/10.1017/S0007114513004054
  16. Burdge G, Lillycrop K. Folic acid supplementation in pregnancy: Are there devils in the detail? British Journal of Nutrition. 2012;108(11):1924-1930. https://doi.org/10.1017/S0007114512003765
  17. Li S, Zhi L, Liu Y, et al. Effect of in ovo feeding of folic acid on the folate metabolism, immune function and epigenetic modification of immune effector molecules of broiler. British Journal of Nutrition. 2016;115(3):411-421. https://doi.org/10.1017/S0007114515004511
  18. Hoile S, Lillycrop K, Grenfell L, et al. Increasing the folic acid content of maternal or post-weaning diets induces differential changes in phosphoenolpyruvatecarboxykinase mRNA expression and promoter methylation in rats. British Journal of Nutrition. 2012;108(5):852-857. https://doi.org/10.1017/S0007114511006155
  19. DeVilbiss E, Gardner R, Newschaffer C, Lee B. Maternal folate status as a risk factor for autism spectrum disorders: A review of existing evidence. British Journal of Nutrition. 2015;114(5):663-672. https://doi.org/10.1017/S0007114515002470
  20. Zhang Y, Hapala J, Brenner H, Wagner W. Individual CpG sites that are associated with age and life expectancy become hypomethylated upon aging. Clinical Epigenetics. 2017;9:9. https://doi.org/10.1186/s13148-017-0315-9
  21. Miriam G. Jasiulionis. Abnormal Epigenetic Regulation of Immune System during Aging. Frontiers in Immunology. 2018;9:197. https://doi.org/10.3389/fimmu.2018.00197
  22. Thunders M. Epigenetics: its understanding is crucial to a sustainable healthcare system. Healthcare. 2015;3:194-204. https://doi.org/10.3390/healthcare3020194
  23. Wallace RG, Twomey LC, Custaud MA, et al. The role of epigenetics in cardiovascular health and ageing: A focus on physical activity and nutrition. Mechanisms of Ageing and Development. 2017;16.pii:S0047-6374(17)30233-6. https://doi.org/10.1016/j.mad.2017.11.013
  24. Khullar M, Cheema BS, Raut SK. Emerging Evidence of Epigenetic Modifications in Vascular Complication of Diabetes. Frontiers in Endocrinology. 2017;8:237. https://doi.org/10.3389/fendo.2017.00237
  25. Oktay AA, Akturk HK, Esenboğa K, et al. Pathophysiology and Prevention of Heart Disease in Diabetes Mellitus. Current Problems in Cardiology. 2018;43(3):68-110. https://doi.org/10.1016/j.cpcardiol.2017.05.001
  26. Schiepers O, Van Boxtel M, De Groot R, et al. DNA methylation and cognitive functioning in healthy older adults. British Journal of Nutrition. 2012;107(5):744-748. https://doi.org/10.1017/S0007114511003576
  27. Lam D, Ancelin ML, Ritchie K, et al. DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression. Psychoneuroendocrinology. 2018;88:1-8. https://doi.org/10.1016/j.psyneuen.2017.11.003
  28. Saxonov S, Berg P, Brutlag DL. A genome-wide analysis of CpGdinucleotides in the human genome distinguishes two distinct classes of promoters.Proceedings of the National Academy of Sciences of the United States of America. 2006;103(5):1412-1417. https://doi.org/10.1073/pnas.0510310103
  29. Zhang Y, Elgizouli M, Schöttker B, et al. Smoking-associated DNA methylation markers predict lung cancer incidence. Clinical Epigenetics. 2016;8:127. https://doi.org/10.1186/s13148-016-0292-4
  30. Gao X, Thomsen H, Zhang Y, et al. The impact of methylation quantitative trait loci (mQTLs) on active smoking-related DNA methylation changes. Clinical Epigenetics. 2017;9:87. https://doi.org/10.1186/s13148-017-0387-6
  31. Stevens JR, Herrick JS, Wolff RK, Slattery ML. Identifying factors associated with the direction and significance of microRNA tumor-normal expression differences in colorectal cancer. BMC Cancer. 2017;17(1):707. https://doi.org/10.1186/s12885-017-3690-x.
  32. Sapienza C, Issa JP. Diet, Nutrition, and Cancer Epigenetics. Annual Review of Nutrition. 2016;36:665-681. https://doi.org/10.1146/annurev-nutr-121415-112634
  33. Alegría-Torres JA, Baccarelli A, Bollati V. Epigenetics and lifestyle. Epigenomics. 2011;3(3):267-277. https://doi.org/10.2217/epi.11.22
  34. Hoffman JB, Petriello MC, Hennig B. Impact of nutrition on pollutant toxicity: an update with new insights into epigenetic regulation. Reviews on environmental health. 2017;32(1-2):65-72. https://doi.org/10.1515/reveh-2016-0041
  35. Abdul QA, Yu BP, Chung HY, et al. Epigenetic modifications of gene expression by lifestyle and environment. Archives of Pharmacal Research. 2017;40(11):1219-1237. https://doi.org/10.1007/s12272-017-0973-3
  36. Ek WE, Tobi EW, Ahsan M, et al. Epigenome-Wide Association Study Consortium. Tea and coffee consumption in relation to DNA methylation in four European cohorts. Human Molecular Genetics. 2017;26(16):3221-3231. https://doi.org/10.1093/hmg/ddx194
  37. Fiorino S, Bacchi-Reggiani L, Sabbatani S, et al. Possible role of tocopherols in the modulation of host microRNA with potential antiviral activity in patients with hepatitis B virus-related persistent infection: a systematic review. British Journal of Nutrition. 2014;112(11):1751-1768. https://doi.org/10.1017/S0007114514002839
  38. Marques-Rocha JL, Milagro FI, Mansego ML, et al. LINE-1 methylation is positively associated with healthier lifestyle but inversely related to body fat mass in healthy young individuals. Epigenetics. 2016;11(1):49-60. https://doi.org/10.1080/15592294.2015.1135286
  39. Arroyo-Jousse V, Garcia-Diaz D, Codner E, Pérez-Bravo F. Epigenetics in type 1 diabetes: TNF-α gene promoter methylation status in Chilean patients with type 1 diabetes mellitus. British Journal of Nutrition. 2016;116(11):1861-1868. https://doi.org/10.1017/S0007114516003846
  40. Zhou D, Hlady RA, Schafer MJ, et al. High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver. Epigenetics. 2017;12(1):55-69. https://doi.org/10.1080/15592294.2016.1261239
  41. McEwen LM, Gatev EG, Jones MJ, et al. DNA methylation signatures in peripheral blood mononuclear cells from a lifestyle intervention for women at midlife: a pilot randomized controlled trial. Applied Physiology, Nutrition, and Metabolism. 2018;43(3):233-239. https://doi.org/10.1139/apnm-2017-0436
  42. Wang T, Garcia JG, Zhang W. Epigenetic Regulation in Particulate Matter-Mediated Cardiopulmonary Toxicities: A Systems Biology Perspective.Current pharmacogenomics and personalized medicine. 2012;10(4):314-321. https://doi.org/10.2174/187569212803901792
  43. Zhang Y, Salam MT, Berhane K, et al. Genetic and epigenetic susceptibility of airway inflammation to PM2.5 in school children: new insights from quantile regression. Environmental Health. 2017;16:88. Published online 2017 Aug 18. https://doi.org/10.1186/s12940-017-0285-6
  44. Zhong J, Karlsson O, Wang G, et al. Proceedings of the National Academy of Sciences. 2017;114(13):3503-3508. https://doi.org/10.1073/pnas.1618545114
  45. Halfon N, Hochstein M. Life Course Health Development: An Integrated Framework for Developing Health, Policy, and Research. Milbank Q. 2002;80(3):433-479. https://doi.org/10.1111/1468-0009.00019
  46. Halfon N, Larson K, Lu M, et al. Lifecourse health development: past, present and future. Maternal and Child Health Journal. 2014;18(2):344-365. https://doi.org/10.1007/s10995-013-1346-2
  47. Handbook of Life Course Health Development. Eds: Halfon N, Forrest CB, Lerner RM, Faustman EM. Springer. 2018;645. Accessed 05.04.18. URL: http://www.springer.com/us/book/9783319471419
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.