Recent years have witnessed a substantial increase in the research focusing on blood pressure variability (BPV). The main value of seasonal BPV is that it, along with other factors such as sympathetic activation, hypercoagulation, and respiratory infections, is one of the major determinants of cardiovascular morbidity excess in winter. All available BP measurement methods can be used in the BPV research. The aim of this review is the analysis of the main seasonal BPV characteristics. The strength of the studies based exclusively on the clinic BP measurement is their statistical power. The use of ambulatory BP monitoring provides information on seasonal changes of the BP profile, which may be important for antihypertensive therapy titration. The outdoor and indoor temperature is considered the main independent climate factor influencing seasonal BPV. However, the investigation of this influence is challenging due to numerous methodological problems. The specific features of clinic and ambulatory seasonal BP changes in two regions of the Russian Federation with different climate conditions are illustrated by original data. Further detailed exploration of the prognostic value of seasonal BPV is an important task from the practical point of view.