The authors studied the level of social adaptation in 1023 students from the middle-level professional health care institutions of the Tver Region and the prevalence of burnout syndrome among the physicians of different specialties (n=772) who worked in this region. The mean social adaptation level in the students was 12.3±0.05 scores; it was minimal in those less than 16 years of age and peaked in the group of 19 years or older. The highest and lowest levels were noted in the Tver students and rural population, respectively. Single parenting and living apart from parents had a profound impact on the development of social disadaptation. The prevalence of the developed burnout syndrome was 6.5±0.9% among the physicians; 23.0±1.5% of them showed its onset. The developed syndrome was 2.5 times more frequently detectable in the males than in the females and 2.5 times more often in persons over 40 years of age. It is necessary to provide access to psychological and psychotherapeutic consultations and to organize psychological trainings for students from secondary professional health care institutions and to set up psychological unloading rooms for physicians and middle-level medical personnel in health care facilities.