Immunological aspects of external genital endometriosis: aseptic inflammation and innate immune responses

Krechetova L.V.; Inviyaeva E.V.; Adamyan L.V.

doi:https://doi.org/10.17116/repro20263202171

Резюме / Abstract:

В эндометрии при менструации и в его фрагментах при внутрибрюшинной регургитации выявлены признаки асептического воспаления. В обзоре обобщены современные данные о возможных механизмах выживания и роста эндометриоидной ткани в несвойственной ей нише с учетом проявления признаков асептического воспаления в местах формирования гетеротопий, дальнейшей хронизации воспалительных реакций в случаях распространенного наружного генитального эндометриоза (НГЭ). Раскрываются особенности функционирования врожденной иммунной системы при НГЭ, описано взаимодействие молекул HLA класса I (и особо HLA-G) с иммуноглобулин-подобными рецепторами клеток-киллеров при НГЭ как ключевого звена в вовлечении NK-клеток в восстановление структуры эндометрия и очищения брюшины от его регургитированных фрагментов при менструации. Приводимые данные раскрывают механизм участия сопутствующих воспалительных процессов в эктопической имплантации эндометрия и формировании очагов НГЭ.

Ключевые слова / Keywords:

наружный генитальный эндометриоз

ретроградная менструация

стерильное воспаление

врожденная иммунная система

естественные киллеры

иммуноглобулин-подобные рецепторы клеток-киллеров

HLA-G

Авторы / Authors:

Любовь Валентиновна Кречетова

ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава России, Москва, Россия

ORCID: 0000-0001-5023-3476

Евгения Владимировна Инвияева

ORCID: 0000-0001-9878-3637

Лейла Владимировна Адамян

ORCID: 0000-0002-3253-4512

Дата поступления:

02.12.2025

Дата принятия в печать:

20.02.2026

Закрыть метаданные

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