Short protocol for antioxidant therapy in men with pathospermia

Vinogradov I.V.; Gablia M.Yu.; Rogozin D.S.

doi:https://doi.org/10.17116/repro20232904193

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MATERIAL AND METHODS

An open, randomized, placebo-controlled, prospective study was conducted with the inclusion of 72 patients with pathospermia, who, as part of their routine practice, were prescribed a biologically active supplement (BAS) «I’ll be a dad. At 40 as in 20», or dietary supplement «I’ll be a dad forte. At 40 like at 20», or placebo for 4 weeks. Patients aged 18 to 45 years with impaired reproductive function in the form of oligo- and/or astheno- and/or teratozoospermia were included. A spermogram was performed before and after treatment, the dynamics of indicators was assessed using the Wilcoxon test.

RESULTS

During therapy in the main group, there was a significant increase in the volume of ejaculate (from 2.7 ml to 3.2 ml, p=0.006), a decrease in the frequency of viscosipathy (from 28% to 6%), a decrease in the concentration of spermatozoa (from 38.5 million/ml to 35 million/ml, p=0.01), an increase in the proportion of progressively motile spermatozoa (from 20% to 23.5%, p=0.0002), an increase in the proportion of morphologically normal spermatozoa (from 1% to 1.5%, p=0.02). In the control group, there were no statistically significant improvements in spermogram parameters.

CONCLUSION

BAS «I’ll be a dad. At 40 as at 20» and BAS «I’ll be a dad forte. At 40 as at 20» have a positive effect on all indicators of spermiological tests in patients with pathospermia. It is advisable to recommend these drugs as part of complex therapy for a period of at least 30 days.

Keywords:

spermogram

male infertility

pathospermia

Authors:

Vinogradov I.V.

Federal State Autonomous Educational Institution of Higher Education "Peoples' Friendship University of Russia" of the Ministry of Education and Science of Russia;
Reproductive Technologies LLC

ORCID: 0000-0001-7469-3952

Gablia M.Yu.

Reproductive Technologies LLC

ORCID: 0000-0002-8176-2597

Rogozin D.S.

Federal State Budgetary Educational Institution of Higher Education "South Ural State Medical University" of the Ministry of Health of Russia

ORCID: 0000-0002-6199-2141

Received:

03.04.2023

Accepted:

18.06.2023

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