The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Batrak N.V.

V.N. Gorodkov Ivanovo Scientific-Research Institute of Maternity and Childhood;
Ivanovo State Medical Academy

Malyshkina A.I.

Ivanovo State Research Institute of Maternity and Childhood n.a. V.N. Gorodkov

Sotnikova N.Yu.

Ivanovo State Medical Academy;
Ivanovo Research Institute of Motherhood and Childhood named after V.N. Gorodkov

Kroshkina N.V.

Ivanovo Research Institute of Motherhood and Childhood named after V.N. Gorodkov

Placental insufficiency in women with threatened early miscarriage and recurrent miscarriage in anamnesis

Authors:

Batrak N.V., Malyshkina A.I., Sotnikova N.Yu., Kroshkina N.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2022;28(3): 18‑24

DOI: 10.17116/repro20222803118

Read: 1354 times

Download PDF (RU)
Contact the author
Table of contents

PLACENTAL INSUFFICIENCY IN WOMEN WITH THREATENED EARLY MISCARRIAGE AND RECURRENT MISCARRIAGE IN ANAMNESIS
PLACENTAL INSUFFICIENCY IN WOMEN WITH THREATENED EARLY MISCARRIAGE AND RECURRENT MISCARRIAGE IN ANAMNESIS

To cite this article:

Batrak NV, Malyshkina AI, Sotnikova NYu, Kroshkina NV. Placental insufficiency in women with threatened early miscarriage and recurrent miscarriage in anamnesis. Russian Journal of Human Reproduction. 2022;28(3):18‑24. (In Russ.)
https://doi.org/10.17116/repro20222803118

 
Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Gene­tic predictors of the formation of placental insu­fficiency in patients with gestational diabetes mellitus without insu­lin requirement. Russian Journal of Human Reproduction. 2025;(5):103-110
Abstract:

BACKGRAUND

Placental insufficiency in the population occurs in 30—45% of cases, and among pregnant women with recurrent pregnancy loss it reaches 75%.

OBJECTIVE

To study the content of CD178 in peripheral blood in women with the threat of abortion and recurrent miscarriage and in women without reproductive dysfunction.

MATERIALS AND METHOD

54 patients with a threat of early interruption and a history of recurrent miscarriage were included in the main group. 36 women with the physiological pregnancy and without a history of reproductive losses were included in the group of control. The relative (percentage) number of CD178 + mononuclear cells was determined on a FACScanto flow cytometer.

RESULTS

Women in the main group more often had complications of this pregnancy, such as gestational diabetes mellitus, placental insufficiency, threatening premature birth, premature birth. Of the main group patients with developed placental insufficiency, the relative content of CD178 + monocytes was lower than those of women in the main group who did not have this complication (p <0.001).

CONCLUSIONS

The method can be used as a screening method for assigning a woman to the risk group for the development of placental insufficiency for the timely appointment of preventive and therapeutic measures in order to reduce perinatal complications for both the mother and the child.

Keywords:

placental insufficiency
recurrent miscarriage

Authors:

Batrak N.V.

V.N. Gorodkov Ivanovo Scientific-Research Institute of Maternity and Childhood;
Ivanovo State Medical Academy

Malyshkina A.I.

Ivanovo State Research Institute of Maternity and Childhood n.a. V.N. Gorodkov

Sotnikova N.Yu.

Ivanovo State Medical Academy;
Ivanovo Research Institute of Motherhood and Childhood named after V.N. Gorodkov

Kroshkina N.V.

Ivanovo Research Institute of Motherhood and Childhood named after V.N. Gorodkov

Received:

13.01.2021

Accepted:

19.05.2022

Close metadata

References:

  1. Krechetova LV, Van’ko LV, Vtorushina VV, Nikolaeva MA, Inviyaeva EV, Tetruashvili NK. Activation of lymphocytes in the formation of immune tolerance in women with recurrent miscarriage. Biohimiya. 2020;85(5):682-694. (In Russ.).
  2. Batrak NV, Malyshkina AI, Sotnikova NYu, Kroshkina NV. Faktory riska i immunologicheskie mekhanizmy ugrozy preryvaniya beremennosti rannih srokov i privychnogo nevynashivaniya. Monografiya. Posvyashchaetsya 90-letnemu yubileyu FGBOU VO IvGMA Minzdrava Rossii i 40-letiyu so dnya osnovaniya FGBU «IvNII MiD im. V.N. Gorodkova» Minzdrava Rossii. Ivanovo: Ivanovskij izdatel’skij dom; 2020. (In Russ.).
  3. Batrak NV, Malyshkina AI, Sotnikova NYu, Kroshkina NV, Peretyatko LP, Fateeva NV. Medical and social factors and pathogenetic mechanisms of early pregnancy loss in women with recurrent miscarriage. Akusherstvo i ginekologiya. 2020;7:79-86. (In Russ.). https://doi.org/10.18565/aig.2020.7.79-86
  4. Patent RF na izobretenie RU 2735999 C1, 11.11.2020. Zayavka №2020113128 ot 26.03.2020. Malyshkina AI, Sotnikova NYu, Kroshkina NV, Batrak NV. Sposob prognozirovaniya placentarnoj nedostatochnosti u zhenshchin s ugrozhayushchim vykidyshem rannih srokov i privychnym nevynashivaniem v anamneze. (In Russ.).
  5. Lyapunov VA, Chistyakova GN, Gazieva IA, Ust’yanceva LS, Remizova II. CD95 as an indicator of late activation of umbilical cord and peripheral blood lymphocytes. Medicinskaya immunologiya. 2015;17(S):273. (In Russ.).
  6. Batrak NV, Malyshkina AI, Sotnikova NYu, Kroshkina NV. The role of CD178+ mononuclear cells in the development of threatening late miscarriage in women with a threat of termination of pregnancy in the first trimester and a history of recurrent miscarriage. Akusherstvo i ginekologiya. 2020;5:70-77. (In Russ.). https://doi.org/10.18565/aig.2020.5.70-77
  7. Patent RF na izobretenie RU 2554827 C1, 27.06.2015. Botasheva TL, Linde VA, Sargsyan OD, Ermolova NV, Palieva NV, Frolov AA, Tyan YuA. Sposob prognozirovaniya placentarnoj nedostatochnosti vo 2 trimestre beremennosti.
  8. Tezikov YuV, Lipatov IS, Gogel’ LYu, Azamatov AR, Ermetov VK. Perinatal approach to the clinical classification of chronic placental insufficiency: standardization of diagnosis and obstetric tactics. Nauka i innovacii v medicine. 2019;4(1):8-15. (In Russ.).
  9. Sotnikova NYu, Malyshkina AI, Kroshkina NV, Batrak NV. Peculiarities of regulation of fas-dependent apoptosis during recurrent early miscarriage. Rossijskij immunologicheskij zhurnal. 2017;11(20)(3):510-512. (In Russ.).
  10. Sagrillo-Fagunde L, Bienvenue-Pariseault J, Legembre P, Vaillancourt C. An insight into the role of the death receptor CD95 throughout pregnancy: Guardian, facilitator, or foe. Birth Defects Research. 2019;111(4):197-211.  https://doi.org/10.1002/bdr2.1470
  11. Huppertz B. Traditional and New Routes of Trophoblast Invasion and Their Implications for Pregnancy Diseases. International Journal of Molecular Sciences. 2019;21(1):289.  https://doi.org/10.3390/ijms21010289
  12. Liu H, Liu X, Jin H, Yang F, Gu W, Li X. Proteomic analysis of knock-down HLA-G in invasion of human trophoblast cell line JEG-3. International Journal of Clinical and Experimental Pathology. 2013;6(11):2451-2459.
  13. Velayuthaprabhu Sh, Matsubayashi H, Archunan G. Beta-2 GPI induced tissue factor and placental apoptosis for the pathophysiology of pregnancy loss in antiphospholipid syndrome. International Journal of Research in Medical Sciences. 2016;4(8):3109-3113. https://doi.org/10.18203/2320-6012.ijrms20162267
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.