Prediction of outcomes of hysteroresectoscopic endometrial destruction in patients with endometrial hyperplasia without atypia

Il'iasova N.A.; Burlev V.A.

doi:https://doi.org/10.17116/repro20202601118

Il'iasova N.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Burlev V.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Prediction of outcomes of hysteroresectoscopic endometrial destruction in patients with endometrial hyperplasia without atypia

Authors:

Il'iasova N.A., Burlev V.A.

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Journal: Russian Journal of Human Reproduction. 2020;26(1): 18‑28

DOI: 10.17116/repro20202601118

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Il'iasova NA, Burlev VA. Prediction of outcomes of hysteroresectoscopic endometrial destruction in patients with endometrial hyperplasia without atypia. Russian Journal of Human Reproduction. 2020;26(1):18‑28. (In Russ.)
https://doi.org/10.17116/repro20202601118

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)

Использование инфографики авторами научных работ

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Abstract:

Background: endometrial hyperplasia is an urgent problem of modern gynecology in the ligament with the possibility of the formation of endometrial cancer. The questions of the effect of the state of endometrial angiogenesis in the preoperative period with endometrial hyperplasia without atypia on subsequent treatment outcomes by the method of hysteroresectoscopic endometrial destruction remain poorly understood. Objectives: to establish a pathogenetic variant of the relationship between the density of endometrial microvessels and the absence of amenorrhea after ablation in patients with endometrial hyperplasia without atypia and to develop a minimally invasive method for predicting outcomes. Method: the use of CD31 immunohistochemical analysis to determine the microvessel density (MVD) in eutopic endometrial tissue, the use of ELISA to determine the VEGF-A content in the blood of patients with endometrial hyperplasia without atypia before performing hysteroresectoscopic endometrial destruction, and the use of binary logistic regression to analyze the results. Results: Using the method of binary logistic regression, a statistically significant dependence of the absence of amenorrhea 6 months after endometrial ablation on the state of both local and systemic angiogenesis was revealed, which allows individual calculation of the absence of amenorrhea 6 months after endometrial ablation based on the MVD parameter. The determination of the content VEGF-A in the blood establishes the prognostic outcome of the surgical operation - the absence of amenorrhea 6 months after the surgical operation based on the found optimal threshold level. Conclusion: the studies performed allowed us to establish and develop a pathogenetic variant of the relationship between the density of endometrial microvessels and the absence of amenorrhea after ablation in patients with endometrial hyperplasia without atypia and to develop a minimally invasive method for predicting outcomes treated.

Keywords:

endometrial hyperplasia

endometrial ablation

angiogenesis

microvessel density

vascular endothelial growth factor

Authors:

Il'iasova N.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Burlev V.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

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References:

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