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Shklyar A.A.

Federal State Budget Institution “Research Center for Obstetrics, Gynecology and Perinatology” Ministry of Healthcare of the Russian Federation, 117997, Russian Federation, Moscow, Oparin’s street, 4

Adamyan L.V.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

Kogan E.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Paramonova N.B.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdrava Rossii, Moskva;
GBOU "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava Rossii, Rossiĭskaia Federatsiia

Kozachenko I.Ph.

Federal State Budget Institution “Research Center for Obstetrics, Gynecology and Perinatology” Ministry of Healthcare of the Russian Federation, 117997, Russian Federation, Moscow, Oparin’s street, 4

Gavrilova T.Yu.

Federal State Budget Institution “Research Center for Obstetrics, Gynecology and Perinatology” Ministry of Healthcare of the Russian Federation, 117997, Russian Federation, Moscow, Oparin’s street, 4

Kononov S.N.

Federal State University Scientific Center of obstetrics, gynecology and perynathology named after V.I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia, 117997

Receptor status of endometrioid heterotopias as the indication for hormonal therapy of nodular and diffuse forms of adenomyosis

Authors:

Shklyar A.A., Adamyan L.V., Kogan E.A., Paramonova N.B., Kozachenko I.Ph., Gavrilova T.Yu., Kononov S.N.

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Journal: Russian Journal of Human Reproduction. 2015;21(2): 88‑93

DOI: 10.17116/repro201521288-93

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Table of contents

RECEPTOR STATUS OF ENDOMETRIOID HETEROTOPIAS AS THE INDICATION FOR HORMONAL THERAPY OF NODULAR AND DIFFUSE FORMS OF ADENOMYOSIS
RECEPTOR STATUS OF ENDOMETRIOID HETEROTOPIAS AS THE INDICATION FOR HORMONAL THERAPY OF NODULAR AND DIFFUSE FORMS OF ADENOMYOSIS

To cite this article:

Shklyar AA, Adamyan LV, Kogan EA, Paramonova NB, Kozachenko IPh, Gavrilova TYu, Kononov SN. Receptor status of endometrioid heterotopias as the indication for hormonal therapy of nodular and diffuse forms of adenomyosis. Russian Journal of Human Reproduction. 2015;21(2):88‑93. (In Russ.)
https://doi.org/10.17116/repro201521288-93

 
Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Objective. To define the indications for conservative therapy of nodular and diffuse forms of adenomyosis by studying the expression of estrogen and progesterone receptors. Material and Methods. 48 patients of reproductive age with adenomyosis were studied. All patients underwent surgical treatment and had preoperative hormonal treatment cancelled 6 months prior to surgery. Histological and immunohistochemical study of surgical specimens was performed. The expression of estrogen and progesterone receptors in the epithelium, stroma and adjacent myometrium heterotopias was measured. Results. Patients with adenomyosis have very non-specific symptoms. The efficiency of different groups of drugs was comparable. The immunohistochemical data showed that the nodular form of adenomyosis is more hormonally dependent than diffuse form. Conclusion. The study showed that although the nodular form of adenomyosis has a higher hormonal status than diffuse, it does not affect the effectiveness of hormonal therapy. Adenomyosis can be treated with hormonal therapy. The lack of effect is the indication for surgical treatment.

Keywords:

nodular adenomyosis
diffuse adenomyosis
estrogen receptors
progesterone receptors
hormonal therapy

Authors:

Shklyar A.A.

Federal State Budget Institution “Research Center for Obstetrics, Gynecology and Perinatology” Ministry of Healthcare of the Russian Federation, 117997, Russian Federation, Moscow, Oparin’s street, 4

Adamyan L.V.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

Kogan E.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Paramonova N.B.

FGBU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova" Minzdrava Rossii, Moskva;
GBOU "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava Rossii, Rossiĭskaia Federatsiia

Kozachenko I.Ph.

Federal State Budget Institution “Research Center for Obstetrics, Gynecology and Perinatology” Ministry of Healthcare of the Russian Federation, 117997, Russian Federation, Moscow, Oparin’s street, 4

Gavrilova T.Yu.

Federal State Budget Institution “Research Center for Obstetrics, Gynecology and Perinatology” Ministry of Healthcare of the Russian Federation, 117997, Russian Federation, Moscow, Oparin’s street, 4

Kononov S.N.

Federal State University Scientific Center of obstetrics, gynecology and perynathology named after V.I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia, 117997

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References:

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