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Zakharova E.E.

Meditsinskaia klinika reproduktsii MAMA, Moskva

Zaletova V.V.

NII urologii Minzdravsotsrazvitiia RF, Moskva

Compact morula stage biopsy improves the diagnostic reliability of preimplantation genetic screening (pgs) and provides a high pregnancy rate (outcome of 215 cycles of ivf-icsi-pgs)

Authors:

Zakharova E.E., Zaletova V.V.

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Journal: Russian Journal of Human Reproduction. 2013;(4): 75‑81

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Table of contents

COMPACT MORULA STAGE BIOPSY IMPROVES THE DIAGNOSTIC RELIABILITY OF PREIMPLANTATION GENETIC SCREENING (PGS) AND PROVIDES A HIGH PREGNANCY RATE (OUTCOME OF 215 CYCLES OF IVF-ICSI-PGS)
COMPACT MORULA STAGE BIOPSY IMPROVES THE DIAGNOSTIC RELIABILITY OF PREIMPLANTATION GENETIC SCREENING (PGS) AND PROVIDES A HIGH PREGNANCY RATE (OUTCOME OF 215 CYCLES OF IVF-ICSI-PGS)

To cite this article:

Zakharova EE, Zaletova VV. Compact morula stage biopsy improves the diagnostic reliability of preimplantation genetic screening (pgs) and provides a high pregnancy rate (outcome of 215 cycles of ivf-icsi-pgs). Russian Journal of Human Reproduction. 2013;(4):75‑81. (In Russ.)

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The present study was the first to demonstrate that compact morula stage biopsy is possible to provide sufficient cellular material for preimplantation genetic diagnosis/screening. Mechanical cell damage is minimal, which considerably facilitates nuclear fixation for FISH. There is enough time after biopsy to obtain PGD/PGS results for embryo transfer on day-5 or 6 in the same IVF cycle. After biopsy almost all embryos examined can reach blastocyst stage and pregnancy rate is comparable with that of IVF program without PGD. It means no negative effect of compact stage biopsy on further human embryo development both in vitro and in vivo.

Keywords:

Day 4 biopsy
compact morula stage
PGD
PGS
FIS

Authors:

Zakharova E.E.

Meditsinskaia klinika reproduktsii MAMA, Moskva

Zaletova V.V.

NII urologii Minzdravsotsrazvitiia RF, Moskva

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