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Marova E.I.

Endocrinology Research Centrer

Rozhinskaia L.Ia.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Voronkova I.A.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Remizov O.V.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia RF

Zavalishina A.I.

Endocrinology Research Center of the Health Ministry, Moscow, Russia

Slashchuk K.Yu.

Endocrinology Research Center of the Health Ministry, Moscow, Russia

Davydov M.I.

Federal state budgetary institution «N.N. Blokhin Russian Cancer Research Center», Ministry of Health of the Russian Federation, Moscow, Russia

Brzhezovsky V.Zh.

N.N. Blokhin Russian Cancer Research Center, Moscow, Russia

Gerasimov S.S.

N.N. Blokhin Russian Cancer Research Center, Moscow, Russia

Chekini A.K.

N.N. Blokhin Russian Cancer Research Center, Moscow, Russia

Stelmach D.K.

N.N. Blokhin Russian Cancer Research Center, Moscow, Russia

Pak M.B.

N.N. Blokhin Russian Cancer Research Center, Moscow, Russia

ACTH-producing medullary thyroid cancer. Clinical case

Authors:

Marova E.I., Rozhinskaia L.Ia., Voronkova I.A., Remizov O.V., Zavalishina A.I., Slashchuk K.Yu., Davydov M.I., Brzhezovsky V.Zh., Gerasimov S.S., Chekini A.K., Stelmach D.K., Pak M.B.

More about the authors

Journal: Problems of Endocrinology. 2016;62(4): 45‑49

DOI: 10.14341/probl201662445-49

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To cite this article:

Marova EI, Rozhinskaia LIa, Voronkova IA, et al. . ACTH-producing medullary thyroid cancer. Clinical case. Problems of Endocrinology. 2016;62(4):45‑49. (In Russ.)
https://doi.org/10.14341/probl201662445-49

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Medullary thyroid cancer with ectopic ACTH production - the disease is extremely rare. The literature describes only a few cases of this disease. Rare ectopic ACTH syndrome caused by medullary thyroid cancer, and the diversity of the clinical picture are responsible for numerous diagnostic errors leading to ineffective treatment. In this regard, we consider it expedient to share our own experience in this area.

Keywords:

medullary thyroid cancer
ectopic acth syndrome
hypercorticoidism

Authors:

Marova E.I.

Endocrinology Research Centrer

Rozhinskaia L.Ia.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Voronkova I.A.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Remizov O.V.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia RF

Zavalishina A.I.

Endocrinology Research Center of the Health Ministry, Moscow, Russia

Slashchuk K.Yu.

Endocrinology Research Center of the Health Ministry, Moscow, Russia

Davydov M.I.

Federal state budgetary institution «N.N. Blokhin Russian Cancer Research Center», Ministry of Health of the Russian Federation, Moscow, Russia

Brzhezovsky V.Zh.

N.N. Blokhin Russian Cancer Research Center, Moscow, Russia

Gerasimov S.S.

N.N. Blokhin Russian Cancer Research Center, Moscow, Russia

Chekini A.K.

N.N. Blokhin Russian Cancer Research Center, Moscow, Russia

Stelmach D.K.

N.N. Blokhin Russian Cancer Research Center, Moscow, Russia

Pak M.B.

N.N. Blokhin Russian Cancer Research Center, Moscow, Russia

List of references:

  1. Ball DW. American thyroid association guidelines for management of medullary thyroid cancer: an adult endocrinology perspective. Thyroid. 2009;19(6):547-550.  doi: 10.1089/thy.2009.0147
  2. Alexandraki KI, Grossman AB. The ectopic ACTH syndrome. Reviews. Endocrine and Metabolic Disorders. 2010;11(2):117-126.  doi: 10.1007/s11154-010-9139-z
  3. Chrisoulidou A, Pazaitou-Panayiotou K, Georgiou E, et al. Ectopic Cushing's syndrome due to CRH secreting liver metastasis in a patient with medullary thyroid carcinoma. Hormones (Athens). 2008;7(3):259-262.
  4. Sheikh-Ali M, Krishna M, Lloyd R, Smallridge RC. Predicting the development of Cushing's syndrome in medullary thyroid cancer: utility of proopiomelanocortin messenger ribonucleic acid in situ hybridization. Thyroid. 2007;17(7):631-634.  doi: 10.1089/thy.2007.0062
  5. Tyer NM, Braunstein GD, Frishberg D. Unusual case of multiple endocrine neoplasia type 2a syndrome without medullary thyroid carcinoma. Endocr Pract. 2011;17(2):E4-E7.  doi: 10.4158/ep10157.CR
  6. Samir Saini NB. Tale of two endocrine organs: medullary thyroid carcinoma (MTC) with ectopic Cushing syndrome. Surgery: Current Research. 2014;05(01). doi: 10.4172/2161-1076.1000217
  7. Willhauck MJ, Popperl G, Rachinger W, et al. An unusual case of ectopic acth syndrome. Exp Clin Endocrinol Diabetes. 2012;120(2):63-67.  doi: 10.1055/s-0031-1297967
  8. Sand M, Uecker S, Bechara FG, et al. Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome. Int Semin Surg Oncol. 2007;4:15.  doi: 10.1186/1477-7800-4-15
  9. Farage M, Costa MA, Godoy-Matos AF. A rare case of Cushing syndrome by cyclic ectopic-ACTH. Arq Bras Endocrinol Metabol. 2012;56(5):324-330.
  10. Barroso-Sousa R, Lerario AM, Evangelista J, et al. Complete resolution of hypercortisolism with sorafenib in a patient with advanced medullary thyroid carcinoma and ectopic ACTH (adrenocorticotropic hormone) syndrome. Thyroid. 2014;24(6):1062-1066. doi: 10.1089/thy.2013.0571
  11. Barbosa SL, Rodien P, Leboulleux S, et al. Ectopic adrenocorticotropic hormone-syndrome in medullary carcinoma of the thyroid: a retrospective analysis and review of the literature. Thyroid. 2005;15(6):618-623.  doi: 10.1089/thy.2005.15.618
  12. Ejaz S, Vassilopoulou-Sellin R, Busaidy NL, et al. Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion: the University of Texas MD Anderson Cancer Center Experience. Cancer. 2011;117(19):4381-4389. doi: 10.1002/cccr.26029
  13. Singh K, Sharma Mc, Jain D, Kumar R. Melanotic medullary carcinoma of thyroid-report of a rare case with brief review of literature. Diagn Pathol. 2008;3:2.  doi: 10.1186/1746-1596-3-2
  14. Kuznetsov NS, Latkina NV, Dobreva EA. Еctopic ACTH syndrome: clinical picture, diagnosis, treatment. Endocrine Surgery. 2012;(1):24-36. (In Russ.). doi: 10.14341/2306-3513-2012-1-24-36
  15. Troshina EA, Bel'tsevich DG, Molashenko NV, Gazizova DO. Diagnosis, differential diagnosis, and treatment of endogenous hypercorticism. Probl Endokrinol (Mosk). 2010;56(2):53-63. (In Russ.). doi: 10.14341/probl201056253-63
  16. Marova EI, Kokshagina NV, Rozhinskaia LI. ACTH-producing neuroendocrine chest wall tumours. Probl Endokrinol (Mosk). 2010;56(5):8-14. (In Russ.). doi: 10.14341/probl20105658-14
  17. Khodakova IV, Arapova SD, Sukhanova GA, et al. Disturbances in the hemostatic system of patients with endogenous hypercorticism and metabolic syndrome. Probl Endokrinol (Mosk). 2010;56(4):34-38. (In Russ.). doi: 10.14341/probl201056434-38
  18. Wells SAJr, et al. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. J Clin Oncol. 2012;30(2):134-141.  doi: 10.1200/JCO.2011.35.5040
  19. Baudry C, Paepegaey AC, Groussin L. Reversal of Cushing’s syndrome by Vandetanib in medullary thyroid carcinoma. N Engl J Med. 2013;369(6):584-586.  doi: 10.1056/nejmc1301428
  20. Nella AA, et al. Vandetanib successfully controls medullary thyroid cancer-related Cushing syndrome in an adolescent patient. J Clin Endocrinol Metab. 2014;99(9):3055-3059. doi: 10.1210/jc.2013-4340

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