Differential and diagnostic, predictive and therapeutic value of test with clomifene in men with a Hypogonadizm

Rozhivanov R.V.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

SPIN RSCI: 8052-3310
ORCID: 0000-0002-5386-4289

Kurbatov D.G.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Kravtsova N.S.

Endocrinology Research Centre, Moscow, Russia

Differential and diagnostic, predictive and therapeutic value of test with clomifene in men with a Hypogonadizm

Authors:

Rozhivanov R.V., Kurbatov D.G., Kravtsova N.S.

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Journal: Problems of Endocrinology. 2016;62(1): 35‑37

DOI: 10.14341/probl201662135-37

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To cite this article:

Rozhivanov RV, Kurbatov DG, Kravtsova NS. Differential and diagnostic, predictive and therapeutic value of test with clomifene in men with a Hypogonadizm. Problems of Endocrinology. 2016;62(1):35‑37. (In Russ.)
https://doi.org/10.14341/probl201662135-37

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Aim. In the real research test with an antiestrogen clomifene is offered for differential diagnostics of potential reversibility of a hypogonadism. Material and methods. After initial determination of levels of testosterone and LH, to 55 men with a hypogonadism clomifene citrate of 50 mg orally daily in the morning for 10 days was administrated. Levels of testosterone and LH repeatedly were defined on the 11th day. Results. The carried-out test with clomifene eliminated a hypogonadism at 85,5% of patients, thus the effect remained at 40%. The test was safe, at one of men of side effects it wasn’t noted. For patients with negative result of test (preservation of a hypogonadism) administration of preparations of testosterone was recommended. Conclusions. Test allows not only to differentiate reversibility of a hypogonadism, but also in some cases completely to eliminate it.

Keywords:

hypogonadism

clomifene

antiestrogens

Authors:

Rozhivanov R.V.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

SPIN RSCI: 8052-3310
ORCID: 0000-0002-5386-4289

Kurbatov D.G.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Kravtsova N.S.

Endocrinology Research Centre, Moscow, Russia

List of references:

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Dedov II, Kalinchenko SY. Vozrastnoy androgennyy defitsit u muzhchin. Moscow: Prakticheskaya meditsina; 2006. 240 p. (In Russ.).

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